Genetic influences on craving for alcohol

Addictive Behaviors

Volumn 38, Issue 2, 2013, Pages 1501-1508

  Agrawal, Arpana ^a   Wetherill, Leah ^b   Bucholz, Kathleen K ^a   Kramer, John ^c   Kuperman, Samuel ^d   Lynskey, Michael T ^a   Nurnberger, John I ^b   Schuckit, Marc ^e   Tischfield, Jay A ^f   Edenberg, Howard J ^b   Foroud, Tatiana ^b   Bierut, Laura J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

Alcohol; Craving; Dopamine; Genes; Genetics; GWAS

Indexed keywords

ADULT; ALCOHOL WITHDRAWAL; ALCOHOLISM; ALPHA SYNUCLEIN GENE; ARTICLE; CHROMOSOME 7; DOPAMINE 1 RECEPTOR GENE; DOPAMINE 2 RECEPTOR GENE; DOPAMINE 3 RECEPTOR GENE; DOPAMINE 4 RECEPTOR GENE; DSM-IV; FACTORIAL ANALYSIS; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; INTEGRIN ALPHA D GENE; MAJOR CLINICAL STUDY; MALE; MONOCARBOXYLATE TRANSPORTER 4 GENE; NEUROBIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84871788830     PISSN: 03064603     EISSN: 18736327     Source Type: Journal    
DOI: 10.1016/j.addbeh.2012.03.021     Document Type: Article

References (59)

1. Agrawal A., Heath A.C., Lynskey M.T. DSM-IV to DSM-5: The impact of proposed revisions on diagnosis of alcohol use disorders. Addiction 2011, 106:1935-1943.
2. Begleiter H., Reich T., Hesselbrock V., Porjesz B., Li T.K., Schuckit M., et al. The collaborative study on the genetics of alcoholism. Alcohol Health and Research World 1995, 19:228-236.
3. Bierut L.J., Agrawal A., Bucholz K.K., Doheny K.F., Laurie C., Pugh E., et al. A genome-wide association study of alcohol dependence. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:5082-5087.
4. Bierut L.J., Madden P.A., Breslau N., Johnson E.O., Hatsukami D., Pomerleau O.F., et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics 2007, 16:24-35.
5. Bierut L.J., Strickland J.R., Thompson J.R., Afful S.E., Cottler L.B. Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings. Drug and Alcohol Dependence 2008, 95:14-22.
6. Blum K., Liu Y., Shriner R., Gold M.S. Reward circuitry dopaminergic activation regulates food and drug craving behavior. Current Pharmaceutical Design 2011, 17:1158-1167.
7. Bohn M.J., Krahn D.D., Staehler B.A. Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcoholism, Clinical and Experimental Research 1995, 19:600-606.
8. Bonsch D., Greifenberg V., Bayerlein K., Biermann T., Reulbach U., Hillemacher T., et al. Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving. Alcoholism, Clinical and Experimental Research 2005, 29:763-765.
9. Bonsch D., Lederer T., Reulbach U., Hothorn T., Kornhuber J., Bleich S. Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Human Molecular Genetics 2005, 14:967-971.
10. Bonsch D., Reulbach U., Bayerlein K., Hillemacher T., Kornhuber J., Bleich S. Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism. Biological Psychiatry 2004, 56:984-986.
11. Bucholz K.K., Cadoret R.J., Cloninger R.C., Dinwiddie S.H., Hesselbrock V., Nurnberger J.I., et al. A new, semi-structured psychiatric interview for use in genetic linkage studies. Journal of Studies on Alcohol 1994, 55:149-158.
12. Bucholz K.K., Heath A.C., Reich T., Hesselbrock V.M., Kramer J.R., Nurnberger J.I., et al. Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcoholism, Clinical and Experimental Research 1996, 20:1462-1471.
13. Buckholtz J.W., Treadway M.T., Cowan R.L., Woodward N.D., Li R., Ansari M.S., et al. Dopaminergic network differences in human impulsivity. Science 2010, 329:532.
14. Carter B.L., Tiffany S.T. Meta-analysis of cue-reactivity in addiction research. Addiction 1999, 94:327-340.
15. Cherpitel C.J., Borges G., Ye Y., Bond J., Cremonte M., Moskalewicz J., et al. Performance of a craving criterion in DSM alcohol use disorders. Journal of Studies on Alcohol and Drugs 2010, 71:674-684.
16. Childress A.R., Mozley P.D., McElgin W., Fitzgerald J., Reivich M., O'Brien C.P. Limbic activation during cue-induced cocaine craving. The American Journal of Psychiatry 1999, 156:11-18.
17. Diana M. The dopamine hypothesis of drug addiction and its potential therapeutic value. Front Psychiatry 2011, 2:64.
18. Drummond D.C. Theories of drug craving, ancient and modern. Addiction 2001, 96:33-46.
19. Drummond D.C., Litten R.Z., Lowman C., Hunt W.A. Craving research: Future directions. Addiction 2000, 95(Suppl. 2):S247-S255.
20. Ehlers C.L., Wilhelmsen K.C. Genomic scan for alcohol craving in mission Indians. Psychiatric Genetics 2005, 15:71-75.
21. Flannery B.A., Roberts A.J., Cooney N., Swift R.M., Anton R.F., Rohsenow D.J. The role of craving in alcohol use, dependence, and treatment. Alcoholism, Clinical and Experimental Research 2001, 25:299-308.
22. Foroud T., Bucholz K.K., Edenberg H.J., Goate A., Neuman R.J., Porjesz B., et al. Linkage of an alcoholism-related severity phenotype to chromosome 16. Alcoholism, Clinical and Experimental Research 1998, 22:2035-2042.
23. Foroud T., Wetherill L.F., Liang T., Dick D.M., Hesselbrock V., Kramer J., et al. Association of alcohol craving with alpha-synuclein (SNCA). Alcoholism, Clinical and Experimental Research 2007, 31:537-545.
24. 18F]DMFP PET study in detoxified alcoholic patients. The American Journal of Psychiatry 2005, 162:1515-1520.
25. Heinz A., Siessmeier T., Wrase J., Hermann D., Klein S., Grusser S.M., et al. Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving. The American Journal of Psychiatry 2004, 161:1783-1789.
26. Hendershot C.S., Witkiewitz K., George W.H., Marlatt G.A. Relapse prevention for addictive behaviors. Substance Abuse Treatment, Prevention, and Policy 2011, 6:17.
27. Hesselbrock M., Easton C., Bucholz K.K., Schuckit M., Hesselbrock V. A validity study of the SSAGA-A comparison with the SCAN. Addiction 1999, 94:1361-1370.
28. Irvine G.B., El-Agnaf O.M., Shankar G.M., Walsh D.M. Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases. Molecular Medicine 2008, 14:451-464.
29. Kalivas P.W., O'Brien C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 2008, 33:166-180.
30. Kalivas P.W., Volkow N.D. The neural basis of addiction: A pathology of motivation and choice. The American Journal of Psychiatry 2005, 162:1403-1413.
31. Kendler K.S., Kalsi G., Holmans P.A., Sanders A.R., Aggen S.H., Dick D.M., et al. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcoholism, Clinical and Experimental Research 2011, 35:963-975.
32. Keyes K.M., Krueger R.F., Grant B.F., Hasin D.S. Alcohol craving and the dimensionality of alcohol disorders. Psychological Medicine 2010, 1-12.
33. Keyes K.M., Krueger R.F., Grant B.F., Hasin D.S. Alcohol craving and the dimensionality of alcohol disorders. Psychological Medicine 2011, 41:629-640.
34. Koyama S., Brodie M.S., Appel S.B. Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons. Journal of Neurophysiology 2007, 97:1977-1985.
35. Kozlowski L.T., Mann R.E., Wilkinson D.A., Poulos C.X. "Cravings" are ambiguous: Ask about urges or desires. Addictive Behaviors 1989, 14:443-445.
36. Kramer J.R., Chan G., Hesselbrock V.M., Kuperman S., Bucholz K.K., Edenberg H.J., et al. A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ). Journal of Studies on Alcohol and Drugs 2010, 71:150-155.
37. Larimer M.E., Palmer R.S., Marlatt G.A. Relapse prevention. An overview of Marlatt's cognitive-behavioral model. Alcohol Research & Health 1999, 23:151-160.
38. Laurie C.C., Doheny K.F., Mirel D.B., Pugh E.W., Bierut L., Bhangale T., et al. Quality control and quality assurance in genotypic data for genome-wide association studies. Genetic Epidemiology 2010, 34(6):591-602.
39. Leggio L., Ray L.A., Kenna G.A., Swift R.M. Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Alcoholism, Clinical and Experimental Research 2009, 33:1539-1544.
40. Lowman C., Hunt W.A., Litten R.Z., Drummond D.C. Research perspectives on alcohol craving: An overview. Addiction 2000, 95(Suppl. 2):S45-S54.
41. Marlatt G.A., Gordon J.R. Relapse prevention 1985, Guilford Press, New York.
42. Mewton L., Slade T., McBride O., Grove R., Teesson M. An evaluation of the proposed DSM-5 alcohol use disorder criteria using Australian national data. Addiction 2011, 106(5):941-950.
43. Monti P.M., Abrams D.B., Binkoff J.A., Zwick W.R., Liepman M.R., Nirenberg T.D., et al. Communication skills training, communication skills training with family and cognitive behavioral mood management training for alcoholics. Journal of Studies on Alcohol 1990, 51:263-270.
44. Moss H.B. Does research support "craving" as a core symptom of substance use disorders in DSM-5?. Psychiatric times 2011, http://www.psychiatrictimes.com/substance-abuse/content/article/10168/1775007.
45. Muthen L.K., Muthen B.O. Mplus user's guide 2007, Muthen & Muthen, Los Angeles, CA. Fifth ed.
46. Narita M., Soma M., Tamaki H., Narita M., Suzuki T. Intensification of the development of ethanol dependence in mice lacking dopamine D(3) receptor. Neuroscience Letters 2002, 324:129-132.
47. O'Brien C.P. Anticraving medications for relapse prevention: A possible new class of psychoactive medications. The American Journal of Psychiatry 2005, 162:1423-1431.
48. O'Brien C. Addiction and dependence in DSM-V. Addiction 2011, 106:866-867.
49. Oslin D.W., Cary M., Slaymaker V., Colleran C., Blow F.C. Daily ratings measures of alcohol craving during an inpatient stay define subtypes of alcohol addiction that predict subsequent risk for resumption of drinking. Drug and Alcohol Dependence 2009, 103:131-136.
50. Perez R.G., Waymire J.C., Lin E., Liu J.J., Guo F., Zigmond M.J. A role for alpha-synuclein in the regulation of dopamine biosynthesis. Journal of Neuroscience 2002, 22:3090-3099.
51. Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics 2006, 38:904-909.
52. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics 2007, 81:559-575.
53. SAS Institute SAS user guide, version 8.2 1999, SAS Institute Inc., Cary, NC.
54. Sinha R., Fox H.C., Hong K.I., Hansen J., Tuit K., Kreek M.J. Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes. Archives of General Psychiatry 2011, 68:942-952.
55. Sinha R., Garcia M., Paliwal P., Kreek M.J., Rounsaville B.J. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Archives of General Psychiatry 2006, 63:324-331.
56. Tupala E., Hall H., Bergstrom K., Sarkioja T., Rasanen P., Mantere T., et al. Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics. Molecular Psychiatry 2001, 6:261-267.
57. Volkow N.D., Wang G.J., Fowler J.S., Logan J., Hitzemann R., Ding Y.S., et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcoholism, Clinical and Experimental Research 1996, 20:1594-1598.
58. Volkow N.D., Wang G.J., Telang F., Fowler J.S., Logan J., Childress A.R., et al. Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. Journal of Neuroscience 2006, 26:6583-6588.
59. World Health Organization International statistical classification of diseases and related health problems 10th revision 2007, Geneva, Switzerland. 10th ed.