Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: Results from the combined pharmacotherapies and behavioral interventions for alcohol dependence (COMBINE) study

Alcoholism: Clinical and Experimental Research

Volumn 33, Issue 9, 2009, Pages 1539-1544

  Leggio, Lorenzo ^a,d   Ray, Lara A ^c   Kenna, George A ^a   Swift, Robert M ^a,b  

^a BROWN UNIVERSITY   (United States)

^b PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

Alcohol craving; Alcohol preference; Glucose; Heavy drinking

Indexed keywords

ACAMPROSATE; NALTREXONE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; BEHAVIOR THERAPY; BODY MASS; BREATH ANALYSIS; COGNITIVE THERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRINKING BEHAVIOR; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DRINKING SCALE; PRIORITY JOURNAL; RATING SCALE; SCORING SYSTEM; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADULT; ALCOHOL DETERRENTS; ALCOHOL DRINKING; ALCOHOLISM; BEHAVIOR THERAPY; BLOOD GLUCOSE; COUNSELING; FEMALE; HUMANS; MALE; MIDDLE AGED; NALTREXONE; OBSESSIVE-COMPULSIVE DISORDER; PSYCHIATRIC STATUS RATING SCALES; TAURINE;

EID: 67650232904     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.00982.x     Document Type: Article

References (38)

1. Addolorato G, Capristo E, Greco AV, Stefanini GF, Gasbarrini G (1998) Influence of chronic alcohol abuse on body weight and energy metabolism: is ethanol consumption in excess a risk factor for obesity or malnutrition? J Intern Med 244 : 387 396.
2. Addolorato G, Capristo E, Leggio L, Ferrulli A, Abenavoli L, Malandrino N, Farnetti S, Domenicali M, D'Angelo C, Vonghia L, Mirijello A, Cardone S, Gasbarrini G (2006) Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients. Alcohol Clin Exp Res 30 : 1933 1937.
3. Anton RF, Moak DH, Latham PK (1996) The obsessive compulsive drinking scale (OCDS). Arch Gen Psychiatry 53 : 225 231.
4. Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A, COMBINE Study Research Group (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 295 : 2003 2017.
5. Anton RF, Randall CL (2005) Measurement and choice of drinking outcome variables in the COMBINE Study. J Stud Alcohol 15 : 104 109, discussion 92-93.
6. Athyros VG, Liberopoulos EN, Mikhailidis DP, Papageorgiou AA, Ganotakis ES, Tziomalos K, Kakafika AI, Karagiannis A, Lambropoulos S, Elisaf M (2007) Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort. Angiology 58 : 689 697.
7. Blum K, Chen TJ, Meshkin B, Downs BW, Gordon CA, Blum S, Mangucci JF, Braverman ER, Arcuri V, Deutsch R, Pons MM (2007) Genotrim, a DNA-customized nutrigenomic product, targets genetic factors of obesity: hypothesizing a dopamine-glucose correlation demonstrating reward deficiency syndrome (RDS). Med Hypotheses 68 : 844 852.
8. COMBINE Study Research Group (2003a) Testing combined pharmacotherapies and behavioral interventions for alcohol dependence (the COMBINE Study): a pilot feasibility study. Alcohol Clin Exp Res 27 : 1123 1131.
9. COMBINE Study Research Group (2003b) Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: rationale and methods. Alcohol Clin Exp Res 27 : 1107 1122.
10. Connelly DM, Unwin JW, Taberner PV (1983) The role of the blood glucose level in determining voluntary ethanol consumption in the LACG and diabetogenic C57BL strains of mice. Biochem Pharmacol 32 : 221 226.
11. Ferrannini E, Camastra S, Gastaldelli A, Maria Sironi A, Natali A, Muscelli E, Mingrone G, Mari A (2004) Beta-cell function in obesity: effects of weight loss. Diabetes 53 (Suppl. 3 S26 S33.
12. Figlewicz DP (2003) Insulin, food intake, and reward. Semin Clin Neuropsychiatry 8 : 82 93.
13. Forsander OA, Pösö AR (1987) Is carbohydrate metabolism genetically related to alcohol drinking? Alcohol Alcohol Suppl 1 : 357 359.
14. Forsander OA, Pösö AR (1988) Hepatic carbohydrate metabolism in rats bred for alcohol preference. Biochem Pharmacol 37 : 2209 2213.
15. Goas JA, Pelham RW, Lippa AS (1979) Endocrine factors contributing to the ethanol preferences of rodents. Pharmacol Biochem Behav 10 : 557 560.
16. Guido M, Romualdi D, Lanzone A (2006) Role of opioid antagonists in the treatment of women with glucoregulation abnormalities. Curr Pharm Des 12 : 1001 1012.
17. Hillemacher T, Kraus T, Rauh J, Weiss J, Schanze A, Frieling H, Wilhelm J, Heberlein A, Gröschl M, Sperling W, Kornhuber J, Bleich S (2007) Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism. Alcohol Clin Exp Res 31 : 950 954.
18. Hillemacher T, Weinland C, Heberlein A, Gröschl M, Schanze A, Frieling H, Wilhelm J, Kornhuber J, Bleich S (2009) Increased levels of adiponectin and resistin in alcohol dependence-possible link to craving. Drug Alcohol Depend 99 : 333 337.
19. Kiefer F, Jahn H, Jaschinski M, Holzbach R, Wolf K, Naber D, Wiedemann K (2001) Leptin: a modulator of alcohol craving? Biol Psychiatry 49 : 782 787.
20. Leggio L, Ferrulli A, Cardone S, Malandrino N, Mirijello A, D'Angelo C, Vonghia L, Miceli A, Capristo E, Kenna GA, Gasbarrini G, Swift RM, Addolorato G (2008b) Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients. A longitudinal study. Alcohol Clin Exp Res 32 : 2047 2053.
21. Leggio L, Ferrulli A, Malandrino N, Miceli A, Capristo E, Gasbarrini G, Addolorato G (2008a) Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients. Alcohol Clin Exp Res 32 : 450 458.
22. Leggio L, Kenna GA, Fenton M, Bonenfant E, Swift RM (2009) Typologies of alcohol dependence. From jellinek to genetics and beyond. Neuropsychol Rev 19 : 115 129.
23. Levin BE (2001) Glucosensing neurons do more than just sense glucose. Int J Obes Relat Metab Disord 25 (Suppl. 5 S68 S72.
24. Lieber CS (1991) Hepatic, metabolic and toxic effects of ethanol. Alcohol Clin Exp Res 15 : 573 592.
25. Liu L, Wang Y, Lam K, Xu A (2008) Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications. Endocr Metab Immune Disord Drug Targets 8 : 89 98.
26. O'Keefe JH, Bybee KA, Lavie CJ (2007) Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 50 : 1009 1014.
27. Raingeard I, Courtet P, Renard E, Bringer J (2004) Naltrexone improves blood glucose control in type 1 diabetic women with severe and chronic eating disorders. Diabetes Care 27 : 847 848.
28. Rao SS, Disraeli P, McGregor T (2004) Impaired glucose tolerance and impaired fasting glucose. Am Fam Physician 69 : 1961 1968.
29. Regitz-Zagrosek V, Lehmkuhl E, Mahmoodzadeh S (2007) Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med 4 (Suppl. B S162 S177.
30. Roberts JS, Anton RF, Latham PK, Moak DH (1999) Factor structure and predictive validity of the Obsessive Compulsive Drinking Scale. Alcohol Clin Exp Res 23 : 1484 1491.
31. Sobell LC, Sobell MB (1992) Timeline followback: a technique for assessing self-reported ethanol consumption, in Measuring Alcohol Consumption: Psychosocial and Biological Methods (Allen J, Litten RZ eds pp 41 72. Humana Press, Totowa, NJ.
32. Stewart SH, Latham PK, Miller PM, Randall P, Anton RF (2008) Blood pressure reduction during treatment for alcohol dependence: results from the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) study. Addiction 103 : 1622 1628.
33. Swift R, Davidson D (1998) Alcohol hangover. Alcohol Health Res World 22 : 54 60.
34. Swift R, Pettinati HM (2005) Choosing pharmacotherapies for the COMBINE Study-process and procedures: an investigational approach to combination pharmacotherapy for the treatment of alcohol dependence. J Stud Alcohol Suppl 15 : 141 147, discussion 140.
35. Umhau JC, Petrulis SG, Diaz R, Rawlings R, George DT (2003) Blood glucose is correlated with cerebrospinal fluid neurotransmitter metabolites. Neuroendocrinology 78 : 339 343.
36. Vonghia L, Leggio L, Ferrulli A, Bertini M, Gasbarrini G, Addolorato G, Alcoholism Treatment Study Group (2008) Acute alcohol intoxication. Eur J Intern Med 19 : 561 567.
37. Williams D, McBride AJ (1998) The drug treatment of alcohol withdrawal symptoms: a systematic review. Alcohol Alcohol 33 : 103 115.
38. Zito KA, Vickers G, Telford L, Roberts DC (1984) Experimentally induced glucose intolerance increases oral ethanol intake in rats. Alcohol 1 : 257 261.