Does developmental exposure to perflurooctanoic acid (PFOA) induce immunopathologies commonly observed in neurodevelopmental disorders?

NeuroToxicology

Volumn 33, Issue 6, 2012, Pages 1491-1498

  Hu, Qing ^a   Franklin, Jason N ^a   Bryan, Ian ^b   Morris, Erin ^a   Wood, Andrew ^a   DeWitt, Jamie C ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Autoreactivity; CD4+CD25+ T cells; Neurodevelopmental disorders; Neuroimmunotoxicology; Perfluorooctanoic acid; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MYELIN BASIC PROTEIN; PERFLUOROOCTANOIC ACID; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CD4+ CD25+ T LYMPHOCYTE; CEREBELLUM; COCULTURE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EX VIVO STUDY; FEMALE; IMMUNOPATHOLOGY; LACTATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NEURODEVELOPMENTAL DISORDER; NEUROLOGIC DISEASE; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; PROGENY; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; WEANING;

ANIMALS; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CAPRYLATES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; FLUOROCARBONS; FORKHEAD TRANSCRIPTION FACTORS; GESTATIONAL AGE; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LACTATION; MALE; MICE; MICE, INBRED C57BL; MYELIN BASIC PROTEIN; NEUROTOXICITY SYNDROMES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SPLEEN;

EPICOCCUM; RODENTIA;

EID: 84871722634     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.10.016     Document Type: Article

References (34)

1. Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001, 167:1245-1253.
2. Corsini E., Oukka M., Pieters R., Kerkvliet N.I., Ponce R., Germolec D.R. Alterations in regulatory T-cells: Rediscovered pathways in immunotoxicology. J Immunotoxicol 2011, 8:251-257.
3. DeWitt J.C., Peden-Adams M.M., Keller J.M., Germolec D.R. Immunotoxicity of perfluorinated compounds: recent developments. Toxicol Pathol 2012, 40:300-311.
4. DeWitt J.C., Copeland C.B., Strynar M.J., Luebke R.W. Perflurooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environ Health Perspect 2008, 116:644-650.
5. Dietert R.R., Dietert J.M. Potential for early-life immune insult including developmental immunotoxicity in autism and autism spectrum disorders: Focus on critical windows of immune vulnerability. J Toxicol Environ Health B Crit Rev 2008, 11:660-680.
6. Goines P., Haapanen L., Boyce R., Duncanson P., Braunschweig D., Delwiche L., Hansen R., Hertz-Picciotto I., Ashwood P., Van de Water J. Autoantibodies to cerebellum in children with autism associate with behavior. Brain Behav Immun 2011, 25:514-523.
7. Grandjean P., Anderson E.W., Budtz-Jørgensen E., Nielsen F., Mølbak K., Weihe P., et al. Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 2012, 307:391-397.
8. Johansson N., Eriksson P., Viberg H. Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. Toxicol Sci 2009, 108:412-418.
9. Johansson N., Fredriksson A., Eriksson P. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioral defects in adult mice. Neurotoxicology 2008, 29:160-169.
10. Keil D.E., Peden-Adams M.M., Wallace S., Ruiz P., Gilkeson G.S. Assessment of trichloroethylene (TCE) exposure in murine strains genetically-prone and non-prone to develop autoimmune disease. J Environ Sci Health A Tox Hazard Subst Environ Eng 2009, 44:443-453.
11. Kipnis J., Avidan H., Caspi R.R., Schwartz M. Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. PNAS 2004, 101:14663-14669.
12. Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I.R., Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999, 5:49-55.
13. Mostafa G.A., Al-Ayadhi L.Y. A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. J Neuroinflammation 2011, 8:71.
14. Oberg H.H., Juricke M., Kabelitz D., Wesch D. Regulation of T cell activation by TLR ligands. Eur J Cell Biol 2011, 90:582-592.
15. Onishchenko N., Fischer C., Wan Ibrahim W.N., Negri S., Spulber S., Cottica D., Ceccatelli S. Prenatal exposure to PFOS or PFOA alters motor function in mice in a sex-related manner. Neurotox Res 2011, 19:452-461.
16. Onore C., Careaga M., Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012, 26:383-392.
17. Peterson R.A. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicol Pathol 2012, 40:186-204.
18. Peden-Adams M.M., Keller J.M., EuDaly J.G., Berger J., Gilkeson G.S., Keil D.E. Suppression of humoral immunity in mice following exposure to perfluoroctane sulfonate. Toxicol Sci 2008, 104:144-154.
19. Pessah I.N., Seegal R.F., Lein P.J., LaSalle J., Yee B.K., Van De Water J., Berman R.F. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 2008, 29:532-545.
20. Pinkas A., Slotkin T.A., Brick-Turin Y., Van der Zee E.A., Yanai J. Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. Neurotoxicol Teratol 2010, 32:182-186.
21. Plitnick L.M., Herzyk D.J. The T-dependent antibody response to keyhole limpet hemocyanin in rodents. Methods Mol Biol 2010, 598:159-171.
22. Reynolds A.D., Banerjee R., Liu J., Gendelman H.E., Mosley R.L. Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. J Leukoc Biol 2007, 82:1083-1094.
23. Ring S., Thome M., Pretsch L., Enk A.H., Mahnke K. Expanded murine regulatory T cells: analysis of phenotype and function in contact hypersensitivity reactions. J Immunol Methods 2007, 326:10-21.
24. Rout U.K., Mungan N.K., Dhossche D.M. Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. Eur Child Adolesc Psychiatry 2012, 21:141-147.
25. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
26. Selgrade M.K., Germolec D.R., Luebke R.W., Smialowicz R.J., Ward M.D., Bowman C.C. Immunotoxicity. Molecular and biochemical toxicology 2008, 765-803. John Wiley & Sons, Inc., Hoboken, NJ. R.C. Smart, E. Hodgson (Eds.).
27. Silva S.C., Correia C., Fesel C., Barreto M., Coutinho A.M., Marques C., et al. Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol 2004, 152:176-182.
28. Singh V.K., Warren R.P., Odell J.D., Warren W.L., Cole P. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav Immun 1993, 7:97-103.
29. Singh V.K., Lin S.X., Newell E., Nelson C. Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed Sci 2002, 9:359-364.
30. Son H.-Y., Soyoung L., Tak E.-N., Cho H.-S., Shin H.-I., Kim S.-H., Yang J.-H. Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice. Environ Toxicol 2009, 24:580-588.
31. Wills S., Cabanlit M., Bennett J., Ashwood P., Amaral D.G., Van de Water J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun 2009, 23:64-74.
32. Yang Q., Xie Y., DePierre J.W. Effects of peroxisome proliferators on the thymus and spleen of mice. Clin Exp Immunol 2000, 122:219-226.
33. Yang Q., Xie Y., Eriksson A.M., Nelson B.D., DePierre J.W. Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluorooctanoic acid in mice. Biochem Pharmacol 2001, 62:1133-1140.
34. Zhang Y., Popovich P. Roles of autoantibodies in central nervous system injury. Discov Med 2011, 11:395-402.