Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 417-421

  Pecic, Stevan ^a   Pakhomova, Svetlana ^b   Newcomer, Marcia E ^b   Morisseau, Christophe ^c   Hammock, Bruce D ^c   Zhu, Zhengxiang ^a   Rinderspacher, Alison ^a   Deng, Shi Xian ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Human liver microsomes stability; Hypertension; Non urea inhibitors; Soluble epoxide hydrolase

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 3 AMINOQUINOLINE DERIVATIVE; 4 TRIFLUOROMETHOXYPHENYL DERIVATIVE; 5 AMINOQUINOLINE DERIVATIVE; 8 AMINOQUINOLINE DERIVATIVE; AMIDE; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; PIPERIDINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; UREA;

ARTICLE; CRYSTAL STRUCTURE; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LIVER MICROSOME; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-INFLAMMATORY AGENTS; CATALYTIC DOMAIN; EPOXIDE HYDROLASES; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PROTEASE INHIBITORS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; VASODILATOR AGENTS;

EID: 84871721627     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.084     Document Type: Article

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