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Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2354-2359

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

(17) Xie, Yuli a Liu, Yidong a Gong, Gangli a Smith, Deborah H a Yan, Fang a Rinderspacher, Alison a Feng, Yan a Zhu, Zhengxiang a Li, Xiangpo a Deng, Shi Xian a Branden, Lars a Vidović, Dušica b Chung, Caty b Schürer, Stephan b Morisseau, Christophe c Hammock, Bruce D c Landry, Donald W a

a Columbia University ^* (United States)

b SCRIPPS RESEARCH INSTITUTE (United States)

c UNIVERSITY OF CALIFORNIA (United States)

Author keywords

HTS; Nanomolar; Non urea; sEH

Indexed keywords

EPOXIDE HYDROLASE; EPOXIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HYPERTENSION; IC 50; INHIBITION KINETICS; NONHUMAN; VASCULITIS;

DRUG DISCOVERY; EPOXIDE HYDROLASES; HUMANS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 63149137137 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2008.09.066 Document Type: Article

Times cited : (31)

References (10)

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2
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- Schmelzer K.R., Kubala L., Newman J.W., Kim I.H., Eiserich J.P., and Hammock B.D. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 9772
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3
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6
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- See the screen results published in Pubchem (AID:1026).

7
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8
- 63149169682
- Analytical data for the representative compounds: 8-42: 1H NMR (300 MHz, CDCl3) δ 6.94 (s, 2H, 5.38 (br, 1H, 3.92-3.89 (m, 1H, 3.62-3.57(m, 2H, 2.83-2.63 (t, 2H, 2.61 (s, 6H, 2.30 (s, 3H, 2.17-2.10 (m, 1H, 1.87-1.83 (m, 4H, 1.74-1.35 (m, 12H, 13C NMR (75 MHz, CD3 OD) δ 172.9, 142.9, 140.6, 132.1, 131.6, 50.6, 44.0,43.1, 35.4, 28.5, 28.3, 24.5, 23.1, 21.3; ESI-MS(M++H, 407.2. 8-47: 1H NMR (300 MHz, CDCl3) δ 6.94 (s, 2H, 5.48 (br, 1H, 3.60 (d, 2H, 3.07 (t, 2H, 2.81 (t, 2H, 2.61 (s, 6H, 2.30 (s, 3H, 2.20-2.05 (m, 1H, 1.88-1.84 (m, 2H, 1.77-1.64 (m, 6H, 1.50-1.38 (m, 1H, 1.35-1.05 (m, 4H, 0.95-0.82 (m, 2H, 13C NMR (75 MHz, CD3OD) δ 174.2, 142.9, 140.7, 132.1, 131.5, 45.9, 44.0, 43.2, 38.2, 31.1, 28.6, 26.7, 26.1, 23.2, 21.3; ESI-MSM++H, 407.3
- ++H): 407.3.

9
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10
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- Kim, I.H.¹ Heirtzler, F.R.² Morisseau, C.³ Nishi, K.⁴ Tsai, H.J.⁵ Hammock, B.D.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.