Effect of matrine on human ether à go-go related gene (HERG) channels expressed in Chinese hamster ovary cells

Chinese Journal of Integrative Medicine

Volumn 16, Issue 5, 2010, Pages 430-434

  Wu, Hong Jin ^a   Zou, An Ruo ^b   Xie, Fang ^a   Du, Yi Mei ^b   Cao, Yu ^a   Liu, Yu Na ^a   Yang, Ji Yuan ^a   Li, Xin Min ^a  

^a Beijing Integrated Traditional and Western Hospital   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chinese hamster ovary cell; Human ether go go related gene; Matrine; Patch clamp technique; Potassium channel

Indexed keywords

MATRINE; POTASSIUM CHANNEL HERG; ALKALOID; ERG1 POTASSIUM CHANNEL; QUINOLIZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; HEART ARRHYTHMIA; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR; ANIMAL; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLISM;

ALKALOIDS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; QUINOLIZINES;

EID: 79952201044     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-010-9997-y     Document Type: Article

References (17)

1. Shah RR. Drugs, QT interval prolongation and ICH E14: the need to get it right. Drug Saf 2005; 28: 115-125.
2. Lastraioli E, Guasti L, Crociani O, Polvani S, Hofmann G, Witchel H, et al. herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res 2004;64:606-611. (Pubitemid 38120900)
3. Sanguinetti MC, Tristani-Firouzi M. HERG potassium channels and cardiac arrhythmia. Nature 2006;440: 463-469.
4. Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995;81:299-307.
5. Zhang Y, Du J, Zhang Y, Sun HL, Pan ZW, Lu YJ, et al. Effects of matrine, oxymatrine and resveratrol on HERG channel expression. Acta Pharm Sin 2007; 42:139-144.
6. + channel currents by quinidine. Circ Res 1993;73:351-359.
7. Deal KK, England SK, Tamkun MM. Molecular physiology of cardiac potassium channels. Physiol Rev 1996;76:49-67. (Pubitemid 26048278)
8. Amos GJ, Jacobson I, Duker G, Carlsson L. Block of HERG-carried K+ currents by the new repolarization delaying agent H345/52. J Cardiovas Electrophysiol 2003;14: 651-658. (Pubitemid 36724392)
9. Sanchez-Chapula JA, Ferer T, Navaro-Polanco RA, Sanguinetti MC. Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Mol Pharmacol 2003; 63: 1051-1058. (Pubitemid 36529923)
10. Tu DN, Liao YH, Zou AR, Du YM, Run Q, Wang XP, et al. Electropharmacological properties of telmisartan in blocking hKv1.5 and HERG potassium channels expressed on Xenopus laevis oocytes. Acta Pharmacol Sin 2008;29:913-922.
11. Su Z, Chen J, Martin RL, McDermott JS, Cox BF, Gopalakrishnan M, et al. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. Biochem Pharmacol 2006; 7l: 278-286. (Pubitemid 41817288)
12. Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, et al. Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Letters 2003; 547: 20-26. (Pubitemid 36829372)
13. Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW. The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics. Eur Biophys J 2004;33:89-97. (Pubitemid 38987095)
14. Shan HL, Yang BF, Zhou YH, Wang H, Li BX. Effects of matrine on aconitine-induced electrophysiological changes in rat ventricular myocytes. J Chin Pharm Sci 2004;13:193-198.
15. Yang BF, Li BX, Zhou YH, Dong DL, Shan HL, Wang L. Inhibitory effects of matrine, E-4031, dofetilide and RP58866 on inward rectifier potassium current in rabbit ventricular myocytes. Chin Pharm Toxicol 2004;18:407-414. (Pubitemid 40292343)
16. Zhang W, Pan ZW, Feng TM, Lu YJ, Dong DL, Yang BF. Effects of matrine on the rapid component of delayed rectifier potassium current in ischemic ventricular myocytes. Chin Pharmacol Bull 2008;24:322-326.
17. Zhao J, Zheng JQ. HERG gene and tumor. Tumour J World 2005;4:148-151.