Dual action spirobicycloimidazolidine-2,4-diones: Antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 488-491

  Iqbal, Zafar ^a   Ali, Sher ^b   Iqbal, Jamshed ^b   Abbas, Qamar ^a   Qureshi, Irfan Zia ^a   Hameed, Shahid ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b Tobe Camp University Road Abbottabad   (Pakistan)

Author keywords

Aldose reductase; Diabetic complications; Enzyme inhibition; Hypoglycemic agents; Imidazolidinediones

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ANTIDIABETIC AGENT; CAMPHOR; CHLORIDE; GLIBENCLAMIDE; GLUCOSE; IMIDAZOLIDINE DERIVATIVE; SPIRO COMPOUND; SPIROBICYCLOIMIDAZOLIDINE 2,4 DIONE DERIVATIVE; SULINDAC; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; GLUCOSE BLOOD LEVEL; IC 50; IN VIVO STUDY; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; BLOOD GLUCOSE; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; HUMANS; HYDANTOINS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50;

EID: 84871713303     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.039     Document Type: Article

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