D6: The 'crowd controller' at the immune gateway

Trends in Immunology

Volumn 34, Issue 1, 2013, Pages 7-12

  Lee, Kit Ming ^a   Nibbs, Robert J B ^a   Graham, Gerard J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Adaptive immunity; Chemokines; Inflammation; Lymph; Receptors

Indexed keywords

CHEMOKINE RECEPTOR D6; CYTOKINE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; GENETIC POLYMORPHISM; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; LYMPH VESSEL ENDOTHELIUM; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ADAPTIVE IMMUNITY; ANIMALS; CHEMOKINES; HUMANS; IMMUNE SYSTEM; IMMUNITY, INNATE; MODELS, IMMUNOLOGICAL; RECEPTORS, CCR10;

EID: 84871712791     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2012.08.001     Document Type: Review

References (48)

1. Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004, 22:891-928.
2. Zlotnik A., Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12:121-127.
3. Murphy P.M., et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 2000, 52:145-176.
4. Mantovani A. The chemokine system: redundancy for robust outputs. Immunol. Today 1999, 20:254-257.
5. Graham G.J. D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes. Eur. J. Immunol. 2009, 39:342-351.
6. Mantovani A., et al. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat. Rev. Immunol. 2006, 6:907-918.
7. Locati M., et al. Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines. Cytokine Growth Factor Rev. 2005, 16:679-686.
8. Bonini J.A., et al. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol. 1997, 16:1249-1256.
9. Nibbs R.J., et al. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J. Biol. Chem. 1997, 272:12495-12504.
10. Nibbs R.J., et al. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. J. Biol. Chem. 1997, 272:32078-32083.
11. Bonecchi R., et al. Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor. J. Immunol. 2004, 172:4972-4976.
12. Savino B., et al. Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence. J. Biol. Chem. 2009, 284:26207-26215.
13. Nibbs R.J., et al. LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. J. Biol. Chem. 1999, 274:17478-17483.
14. Townson J.R., et al. Aminooxypentane addition to the chemokine macrophage inflammatory protein-1alpha P increases receptor affinities and HIV inhibition. J. Biol. Chem. 2000, 275:39254-39261.
15. Blackburn P.E., et al. Purification and biochemical characterization of the D6 chemokine receptor. Biochem. J. 2004, 379:263-272.
16. Weber M., et al. The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Mol. Biol. Cell 2004, 15:2492-2508.
17. McCulloch C.V., et al. Multiple roles for the carboxy-terminal tail of the chemokine scavenger D6. J. Biol. Chem. 2008, 283:7972-7982.
18. Bonecchi R., et al. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood 2008, 112:493-503.
19. Madigan J., et al. Chemokine scavenger D6 is expressed by trophoblasts and AIDS the survival of mouse embryos transferred into allogeneic recipients. J. Immunol. 2010, 184:3202-3212.
20. Martinez de la Torre Y., et al. Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:2319-2324.
21. Nibbs R.J., et al. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am. J. Pathol. 2001, 158:867-877.
22. Hansell C.A., et al. Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. Blood 2011, 117:5413-5424.
23. McKimmie C.S., et al. Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. J. Immunol. 2008, 181:3353-3363.
24. Jamieson T., et al. The chemokine receptor D6 limits the inflammatory response in vivo. Nat. Immunol. 2005, 6:403-411.
25. Martinez de la Torre Y., et al. Increased inflammation in mice deficient for the chemokine decoy receptor D6. Eur. J. Immunol. 2005, 35:1342-1346.
26. Bordon Y., et al. The atypical chemokine receptor D6 contributes to the development of experimental colitis. J. Immunol. 2009, 182:5032-5040.
27. Vetrano S., et al. The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6. Gut 2010, 59:197-206.
28. Whitehead G.S., et al. The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity. Am. J. Respir. Crit. Care Med. 2007, 175:243-249.
29. Di Liberto D., et al. Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med. 2008, 205:2075-2084.
30. Mantovani A., et al. Cancer-related inflammation. Nature 2008, 454:436-444.
31. Nibbs R.J., et al. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J. Clin. Invest. 2007, 117:1884-1892.
32. Wiederholt T., et al. Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C. Hum. Immunol. 2008, 69:861-866.
33. Codullo V., et al. An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Ann. Rheum. Dis. 2011, 70:1115-1121.
34. Wu F.Y., et al. Chemokine decoy receptor d6 plays a negative role in human breast cancer. Mol. Cancer Res. 2008, 6:1276-1288.
35. Zeng X.H., et al. Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. Breast Cancer Res. Treat. 2011, 125:715-727.
36. Graham G.J., McKimmie C.S. Chemokine scavenging by D6: a movable feast?. Trends Immunol. 2006, 27:381-386.
37. Dawson T.C., et al. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am. J. Pathol. 2000, 156:1951-1959.
38. Herbold W., et al. Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect. Immun. 2010, 78:2620-2630.
39. Cardona A.E., et al. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 2008, 112:256-263.
40. Liu L., et al. Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177:17-21.
41. Forster R., et al. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008, 8:362-371.
42. Sallusto F., et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 1998, 28:2760-2769.
43. Sozzani S., et al. Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J. Immunol. 1998, 161:1083-1086.
44. Proudfoot A.E., et al. Strategies for chemokine antagonists as therapeutics. Semin. Immunol. 2003, 15:57-65.
45. Johnson L.A., et al. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med. 2006, 203:2763-2777.
46. Lee K.M., et al. D6 facilitates cellular migration, and fluid flow, to lymph nodes by suppressing lymphatic congestion. Blood 2011, 118:6220-6229.
47. Palframan R.T., et al. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 2001, 194:1361-1373.
48. Singh M.D., et al. Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis. Am. J. Pathol 2012, http://www.sciencedirect.com/science/article/pii/S000294401200524X.