Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis

American Journal of Pathology

Volumn 181, Issue 4, 2012, Pages 1158-1164

  Singh, Mark D ^a   King, Vicky ^a   Baldwin, Helen ^a   Burden, David ^b   Thorrat, Anne ^b   Holmes, Susan ^c   McInnes, Iain B ^a   Nicoll, Ruairidh ^a   Shams, Kave ^b   Pallas, Kenneth ^a   Jamieson, Thomas ^d   Lee, Kit Ming ^a   Carballido, Jose M ^e   Rot, Antal ^f,g   Graham, Gerard J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

^c GLASGOW ROYAL INFIRMARY   (United Kingdom)

^d BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^e NOVARTIS PHARMA AG   (Switzerland)

^f Novartis Institutes for BioMedical Research Vienna   (Austria)

^g MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE SCAVENGING RECEPTOR D6; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM; EPIDERMIS; HUMAN; HUMAN CELL; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SKIN DEFECT; SKIN INFLAMMATION; UPREGULATION;

ANIMALS; EPIDERMIS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MICE; PSORIASIS; RECEPTORS, CCR10; RNA, MESSENGER; WOUNDS AND INJURIES;

EID: 84866517824     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.06.042     Document Type: Article

References (25)

1. B.J. Nickoloff, J.Z. Qin, F.O. Nestle Immunopathogenesis of psoriasis Clin Rev Allergy Immunol 33 2007 45 56 (Pubitemid 351514147)
2. P.C. van de Kerkhof The evolution of the psoriatic lesion Br J Dermatol 157 2007 4 15 (Pubitemid 46934247)
3. J.E. Gudjonsson, J. Ding, X. Li, R.P. Nair, T. Tejasvi, Z.S. Qin, D. Ghosh, A. Aphale, D.L. Gumucio, J.J. Voorhees, G.R. Abecasis, J.T. Elder Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin J Invest Dermatol 129 2009 2795 2804
4. A. Rot, U.H. von Andrian Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells Annu Rev Immunol 22 2004 891 928 (Pubitemid 38680444)
5. B. Homey, S. Meller Chemokines and other mediators as therapeutic targets in psoriasis vulgaris Clin Dermatol 26 2008 539 545
6. B.J. Nickoloff, H. Xin, F.O. Nestle, J.Z. Qin The cytokine and chemokine network in psoriasis Clin Dermatol 25 2007 568 573 (Pubitemid 350103656)
7. G.J. Graham D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes Eur J Immunol 39 2009 342 351
8. A. Mantovani, R. Bonecchi, M. Locati Tuning inflammation and immunity by chemokine sequestration: decoys and more Nat Rev Immunol 6 2006 907 918 (Pubitemid 44851733)
9. R.J. Nibbs, S.M. Wylie, J. Yang, N.R. Landau, G.J. Graham Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6 J Biol Chem 272 1997 32078 32083 (Pubitemid 28011878)
10. A.M. Fra, M. Locati, K. Otero, M. Sironi, P. Signorelli, M.L. Massardi, M. Gobbi, A. Vecchi, S. Sozzani, A. Mantovani Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6 J Immunol 170 2003 2279 2282 (Pubitemid 36245612)
11. M. Weber, E. Blair, C.V. Simpson, M. O'Hara, P.E. Blackburn, A. Rot, G.J. Graham, R.J. Nibbs The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines Mol Biol Cell 15 2004 2492 2508 (Pubitemid 38580663)
12. R.J. Nibbs, E. Kriehuber, P.D. Ponath, D. Parent, S. Qin, J.D. Campbell, A. Henderson, D. Kerjaschki, D. Maurer, G.J. Graham, A. Rot The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors Am J Pathol 158 2001 867 877 (Pubitemid 32221780)
13. J. Madigan, D.J. Freeman, F. Menzies, S. Forrow, S.M. Nelson, A. Young, A. Sharkey, A. Moffett, G.J. Graham, I.A. Greer, A. Rot, R.J. Nibbs Chemokine scavenger d6 is expressed by trophoblasts and AIDS the survival of mouse embryos transferred into allogeneic recipients J Immunol 184 2010 3202 3212
14. Y. Martinez de la Torre, C. Buracchi, E.M. Borroni, J. Dupor, R. Bonecchi, M. Nebuloni, F. Pasqualini, A. Doni, E. Lauri, C. Agostinis, R. Bulla, D.N. Cook, B. Haribabu, P. Meroni, D. Rukavina, L. Vago, F. Tedesco, A. Vecchi, S.A. Lira, M. Locati, A. Mantovani Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6 Proc Natl Acad Sci USA 104 2007 2319 2324 (Pubitemid 46391395)
15. C.S. McKimmie, A.R. Fraser, C. Hansell, L. Gutierrez, S. Philipsen, L. Connell, A. Rot, M. Kurowska-Stolarska, P. Carreno, M. Pruenster, C.C. Chu, G. Lombardi, C. Halsey, I.B. McInnes, F.Y. Liew, R.J. Nibbs, G.J. Graham Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1 J Immunol 181 2008 3353 3363
16. T. Jamieson, D.N. Cook, R.J. Nibbs, A. Rot, C. Nixon, P. McLean, A. Alcami, S.A. Lira, M. Wiekowski, G.J. Graham The chemokine receptor D6 limits the inflammatory response in vivo Nat Immunol 6 2005 403 411 (Pubitemid 41716781)
17. Y. Martinez de la Torre, M. Locati, C. Buracchi, J. Dupor, D.N. Cook, R. Bonecchi, M. Nebuloni, D. Rukavina, L. Vago, A. Vecchi, S.A. Lira, A. Mantovani Increased inflammation in mice deficient for the chemokine decoy receptor D6 Eur J Immunol 35 2005 1342 1346 (Pubitemid 40691415)
18. S. Vetrano, E.M. Borroni, A. Sarukhan, B. Savino, R. Bonecchi, C. Correale, V. Arena, M. Fantini, M. Roncalli, A. Malesci, A. Mantovani, M. Locati, S. Danese The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6 Gut 59 2010 197 206
19. G.S. Whitehead, T. Wang, L.M. DeGraff, J.W. Card, S.A. Lira, G.J. Graham, D.N. Cook The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity Am J Respir Crit Care Med 175 2007 243 249 (Pubitemid 46203127)
20. R.J. Nibbs, D.S. Gilchrist, V. King, A. Ferra, S. Forrow, K.D. Hunter, G.J. Graham The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors J Clin Invest 117 2007 1884 1892 (Pubitemid 47036322)
21. H. Ruchatz, B.P. Leung, X.Q. Wei, I.B. McInnes, F.Y. Liew Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology J Immunol 160 1998 5654 5660 (Pubitemid 28267861)
22. A. Johnston, X. Xing, A.M. Guzman, M. Riblett, C.M. Loyd, N.L. Ward, C. Wohn, E.P. Prens, F. Wang, L.E. Maier, S. Kang, J.J. Voorhees, J.T. Elder, J.E. Gudjonsson IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression J Immunol 186 2011 2613 2622
23. Y. Yoshinaga, M. Higaki, S. Terajima, E. Ohkubo, T. Nogita, N. Miyasaka, M. Kawashima Detection of inflammatory cytokines in psoriatic skin Arch Dermatol Res 287 1995 158 164
24. F.O. Nestle, C. Conrad, A. Tun-Kyi, B. Homey, M. Gombert, O. Boyman, G. Burg, Y.J. Liu, M. Gilliet Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production J Exp Med 202 2005 135 143 (Pubitemid 41002916)
25. V. Codullo, H.M. Baldwin, M.D. Singh, A.R. Fraser, C. Wilson, A. Gilmour, A.J. Hueber, C. Bonino, I.B. McInnes, C. Montecucco, G.J. Graham An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis Ann Rheum Dis 70 2011 1115 1121