Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole

Tropical Medicine and International Health

Volumn 18, Issue 1, 2013, Pages 75-84

  Caldas, Ivo Santana ^a   da Matta Guedes, Paulo Marcos ^b   dos Santos, Fabiane Matos ^c   de Figueiredo Diniz, Lívia ^a   Martins, Tassiane Assíria Fontes ^a   da Silva do Nascimento, Alvaro Fernando ^a   Azevedo, Maira Araújo ^a   de Lima, Wanderson Geraldo ^a   Neto, Raimundo Marques Nascimento ^a   Torres, Rosália Morais ^d   Talvani, André ^a   Bahia, Maria Terezinha ^a  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^c FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Benznidazole; Chagas cardiomyopathy; Electrocardiography; Fibrosis; Trypanosoma cruzi

Indexed keywords

BENZNIDAZOLE; COLLAGEN;

ABNORMALITY; ANTIPARASITE DEFENSE; CANID; CARDIOLOGY; CHAGAS DISEASE; COLLAGEN; INFECTIOUS DISEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROCARDIOGRAPHY; FIRST DEGREE ATRIOVENTRICULAR BLOCK; HEART MUSCLE FIBROSIS; HEART RIGHT ATRIUM; HEART VENTRICLE OVERLOAD; NONHUMAN; PROSPECTIVE STUDY; TRYPANOSOMA CRUZI;

ANIMALS; ATRIOVENTRICULAR BLOCK; CHAGAS DISEASE; CHRONIC DISEASE; CICATRIX; COLLAGEN; DOGS; DRUG RESISTANCE; ELECTROCARDIOGRAPHY; FIBROSIS; HEART ATRIA; MYOCARDIUM; NITROIMIDAZOLES; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ANIMALIA; CANIS FAMILIARIS; TRYPANOSOMA CRUZI;

EID: 84871700984     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/tmi.12002     Document Type: Article

References (45)

1. Andrade SG (1990) Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice. Memórias do Instituto Oswaldo Cruz85, 17-27.
2. Andrade SG, Rassi A, Magalhães JB et al. (1992) Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Transactions of the Royal Society of Tropical Medicine and Hygiene86, 624-626.
3. Andrade ZA, Andrade SG, Sadigursky M et al. (1997) The indeterminate phase of Chagas' disease: ultrastructural characterization of cardiac changes in the canine model. American Society of Tropical Medicine and Hygiene57, 328-336.
4. Andrade AL, Zicker F, Rassi A et al. (1998) Early electrocardiographic abnormalities in Trypanosoma cruzi-seropositive children. The American Journal of Tropical Medicine and Hygiene59, 530-534.
5. Andrade AL, Martelli CM, Oliveira RM et al. (2004) Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a 6-year follow-up. The American Journal of Tropical Medicine and Hygiene71, 594-597.
6. Ávila HA, Sigman DS, Cohen LM et al. (1991) Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolation from whole blood lysates: diagnosis of chronic Chagas' disease. Molecular and Biochemical Parasitology40, 211-222.
7. Bahia-Oliveira LM, Gomes JA, Cançado JR et al. (2000) Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30years ago. The Journal of Infectious Diseases182, 634-638.
8. Biolo A, Ribeiro AL & Clausell N (2010) Chagas cardiomyopathy-where do we stand after a hundred years?Progress in Cardiovascular Diseases52, 300-316.
9. Bustamante JM, Rivarola HW, Fernandez AR et al. (2002) Trypanosoma cruzi reinfections in mice determine the severity of cardiac damage. International Journal for Parasitology15, 889-896.
10. Caldas IS, Talvani A, Caldas S et al. (2008) Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions. Journal of Parasitology Research103, 413-421.
11. Cançado JR (2002) Long term evaluation of etiological treatment of chagas disease with benznidazole. Revista do Instituto de Medicina Tropical de São Paulo44, 29-37.
12. Chiari E, Dias JC, Lana M & Chiari CA (1989) Hemocultures for the parasitological diagnosis of human chronic Chagas' disease. Revista da Sociedade Brasileira de Medicina Tropical22, 19-23.
13. Coura JR (2007) Chagas disease: what is known and what is needed-a background article. Memórias do Instituto Oswaldo Cruz102(Suppl 1), 113-122.
14. Dilaveris PE & Gialafus JE (2001) P wave dispersion: a novel predictor of paroxysmal AF. Annals of Noninvasive Electrocardiology6, 159-165.
15. Diniz LF, Caldas IS, Guedes PM et al. (2010) Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy54, 2979-2986.
16. Dujardin JC, Gonzalez-Pacanowska D, Croft SL et al. (2010) Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas. Trends in Parasitology26, 395-403.
17. Eickhoff CS, Lawrence CT, Sagartz JE et al. (2010) ECG detection of murine chagasic cardiomyopathy. Journal of Parasitology96, 758-764.
18. Filardi LS & Brener Z (1987) Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Transactions of the Royal Society of Tropical Medicine and Hygiene81, 755-759.
19. Garcia S, Ramos CO, Senra JF et al. (2005) Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations. Antimicrobial Agents and Chemotherapy49, 1521-1528.
20. Guedes PM, Veloso VM, Tafuri WL et al. (2002) The dog as model for chemotherapy of the Chagas' disease. Acta Tropica84, 9-17.
21. Guedes PM, Veloso VM, Talvani A et al. (2010) Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs. Veterinary Immunology and Immunopathology138, 106-113.
22. Hanton G & Rabemampianina Y (2006) The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate. Laboratory Animals Limited40, 123-136.
23. Lana M. & Chiari E (1986) Caracterização biológica comparativa das cepas Berenice e Berenice-78 de Trypanosoma cruzi isoladas da mesma paciente em diferentes períodos. Memórias do Instituto Oswaldo Cruz81, 247-253.
24. Lana M, Chiari E & Tafuri WL (1992) Experimental Chagas' disease in dogs. Memórias do Instituto Oswaldo Cruz87, 59-71.
25. Laranja F, Pellegrino J & Dias E (1949) Experimental Chagas heart disease. American Heart Journal37, 646.
26. Maguire JH, Mott KE, Lehman JS et al. (1983) Relationship of electrocardiographic abnormalities and seropositivity to Trypanosoma cruzi within a rural community in northeast Brazil. American Heart Journal105, 287-294.
27. Melo L, Caldas IS, Azevedo MA et al. (2011) Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-infected dogs. The American Journal of Tropical Medicine and Hygiene84, 325-331.
28. Noszczyk-Nowak A, Szalas A, Paslawska U et al. (2011) Comparison of P-wave dispersion in healthy dogs, dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction. Acta Veterinaria Scandinavica53, 18.
29. Pellegrino J (1947) O electrocardiograma na doença de Chagas experimental no cão. Brasil-Médico61, 3-10.
30. Postan M, Bailey JJ, Dvorak JA, McDaniel JP & Pottala EW (1987) Studies of Trypanosoma cruzi clones in inbred mice. III. Histopathological and electrocardiographical responses to chronic infection. The American Journal of Tropical Medicine and Hygiene37, 541-549.
31. Salazar-Schettino PM, Perera R, Ruiz-Hernandez AL et al. (2009) Chagas disease as a cause of symptomatic chronic myocardopathy in Mexican children. The Pediatric Infectious Disease Journal28, 1011-1013.
32. Santos FM, Lima WG, Gravel AS et al. (2012) Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease. Journal of Antimicrobial Chemotherapy67, 1987-1995.
33. Schlemper BR Jr, Ishida MM, Steindel M & Gargioni R (1986) Very large trypomastigotes as a morphological pattern of strains of Trypanosoma cruzi in the southern region of Brazil. Memórias do Instituto Oswaldo Cruz81, 191-198.
34. Schmunis GA (2007) Epidemiology of Chagas disease in non-endemic countries: the role of international migration. Memórias do Instituto Oswaldo Cruz102, 75-85.
35. Silveira CA, Castillo E & Castro C (2000) Evaluation of a specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase. Revista da Sociedade Brasileira de Medicina Tropical33, 191-196.
36. Sosa ES & Segura EL (1999) Treatment of Trypanosoma cruzi infection in the undetermined phase. Experience and current guidelines of treatment in Argentina. Memórias do Instituto Oswaldo Cruz94, 363-365.
37. Sosa-Estani S, Viotti R & Segura EL (2009) Therapy, diagnosis and prognosis of chronic Chagas disease: insight gained in Argentina. Memórias do Instituto Oswaldo Cruz104, 167-180.
38. Strauss DG, Poole JE, Wagner GS et al. (2011) An ECG index of myocardial scar enhances prediction of defibrillator shocks: an analysis of the Sudden Cardiac Death in Heart Failure Trial. Heart Rhythm8, 38-45.
39. Tarleton RL, Reithinger R, Urbina JA, Kitron U & Gurtler RE (2007) The challenges of Chagas disease - grim outlook or glimmer of hope. PLoS Medicine4, 332.
40. Urbina JA (2009) Ergosterol biosynthesis and drug development for Chagas disease. Memórias do Instituto Oswaldo Cruz104, 311-318.
41. Veloso VM, Carneiro CM, Toledo MJ et al. (2001) Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains. Memórias do Instituto Oswaldo Cruz96, 1005-1011.
42. Viotti RJ, Vigliano C, Laucella S et al. (2004) Value of echocardiography for diagnosis and prognosis of chronic Chagas disease cardiomyopathy without heart failure. Heart90, 655-660.
43. Weber KT, Jalil JE, Janicki JS et al. (1989) Myocardial collagen remodeling in pressure overload hypertrophy. A case for interstitial heart disease. American Journal of Hypertension2, 931-940.
44. Williams-Blangero S, Magalhaes T, Rainwater E et al. (2007) Electrocardiographic characteristics in a population with high rates of seropositivity for Trypanosoma cruzi infection. The American Journal of Tropical Medicine and Hygiene77, 495-499.
45. Yun O, Lima MA, Ellman T et al. (2009) Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala and Bolivia: 10-year experience of Medecins Sans Frontieres. PLoS Neglected Tropical Diseases3, 488.