Chagas Cardiomyopathy-Where Do We Stand After a Hundred Years?

Progress in Cardiovascular Diseases

Volumn 52, Issue 4, 2010, Pages 300-316

  Biolo, Andréia ^a   Ribeiro, Antonio L ^b   Clausell, Nadine ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b University Hospital   (Brazil)

Author keywords

Cardiomyopathy; Chagas disease; T. cruzi

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; BENZNIDAZOLE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CAPTOPRIL; CARVEDILOL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; METOPROLOL; NIFURTIMOX; SPIRONOLACTONE; WARFARIN;

CARDIAC ALLOGRAFT VASCULOPATHY; CARDIOVASCULAR RISK; CHAGAS DISEASE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CLINICAL TRIAL; DEFIBRILLATION; DISEASE CLASSIFICATION; DRUG EFFICACY; DRUG TOLERABILITY; DYSAUTONOMIA; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART SCINTISCANNING; HEART TRANSPLANTATION; HOLTER MONITORING; HOST PARASITE INTERACTION; HUMAN; LABORATORY DIAGNOSIS; MICROANGIOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIMARY PREVENTION; PROGNOSIS; RECURRENT DISEASE; REVIEW; SECONDARY PREVENTION; SERODIAGNOSIS; THORAX RADIOGRAPHY; THROMBOEMBOLISM; TREATMENT INDICATION; TRYPANOSOMA CRUZI;

CARDIOVASCULAR AGENTS; CHAGAS CARDIOMYOPATHY; DEVELOPING COUNTRIES; DISEASE PROGRESSION; HEART TRANSPLANTATION; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PREDICTIVE VALUE OF TESTS; PREVENTIVE HEALTH SERVICES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 73349119683     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcad.2009.11.008     Document Type: Review

References (162)

1. Chagas C. Uber eine neue Trypanosomiasis des Menschen. Arch Schiffs Tropenhyg 13 (1909) 351-353
2. Prata A. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1 (2001) 92-100
3. WHO Expert Commitee. Control of Chagas disease. World Health Organ Tech Rep Ser 905 (2002) i-109
4. Schmunis G.A. Epidemiology of Chagas disease in nonendemic countries: the role of international migration. Mem Inst Oswaldo Cruz 102 (2007) 75-85
5. Dobarro D., Gomez-Rubin C., Sanchez-Recalde A., et al. Chagas' heart disease in Europe: an emergent disease?. J Cardiovasc Med (Hagerstown) 9 (2008) 1263-1267
6. Bern C., Montgomery S.P., Herwaldt B.L., et al. Evaluation and treatment of Chagas disease in the United States: a systematic review. JAMA 298 (2007) 2171-2181
7. Bern C., Montgomery S.P., Katz L., et al. Chagas disease and the US blood supply. Curr Opin Infect Dis 21 (2008) 476-482
8. Parada H., Carrasco H.A., Anez N., et al. Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological study. Int J Cardiol 60 (1997) 49-54
9. Punukollu G., Gowda R.M., Khan I.A., et al. Clinical aspects of the Chagas' heart disease. Int J Cardiol 115 (2007) 279-283
10. Barretto A.C., and Ianni B.M. The undetermined form of Chagas' heart disease: concept and forensic implications. Sao Paulo Med J 113 (1995) 797-801
11. Marin-Neto J.A., Cunha-Neto E., Maciel B.C., et al. Pathogenesis of chronic Chagas heart disease. Circulation 115 (2007) 1109-1123
12. Rossi M.A., and Bestetti R.B. The challenge of chagasic cardiomyopathy. The pathologic roles of autonomic abnormalities, autoimmune mechanisms and microvascular changes, and therapeutic implications. Cardiology 86 (1995) 1-7
13. Pereira Barretto A.C., Mady C., Arteaga-Fernandez E., et al. Right ventricular endomyocardial biopsy in chronic Chagas' disease. Am Heart J 111 (1986) 307-312
14. Carrasco Guerra H.A., Palacios-Pru E., Dagert de Scorza C., et al. Clinical, histochemical, and ultrastructural correlation in septal endomyocardial biopsies from chronic chagasic patients: detection of early myocardial damage. Am Heart J 113 (1987) 716-724
15. Higuchi M.L., De Morais C.F., Pereira Barreto A.C., et al. The role of active myocarditis in the development of heart failure in chronic Chagas' disease: a study based on endomyocardial biopsies. Clin Cardiol 10 (1987) 665-670
16. Tarleton R.L. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 31 (2001) 550-554
17. Jones E.M., Colley D.G., Tostes S., et al. Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathy. Am J Trop Med Hyg 48 (1993) 348-357
18. Bellotti G., Bocchi E.A., de Moraes A.V., et al. In vivo detection of Trypanosoma cruzi antigens in hearts of patients with chronic Chagas' heart disease. Am Heart J 131 (1996) 301-307
19. Zhang L., and Tarleton R.L. Parasite persistence correlates with disease severity and localization in chronic Chagas' disease. J Infect Dis 180 (1999) 480-486
20. Palomino S.A., Aiello V.D., and Higuchi M.L. Systematic mapping of hearts from chronic chagasic patients: the association between the occurrence of histopathological lesions and Trypanosoma cruzi antigens. Ann Trop Med Parasitol 94 (2000) 571-579
21. Higuchi M.L., Gutierrez P.S., Aiello V.D., et al. Immunohistochemical characterization of infiltrating cells in human chronic chagasic myocarditis: comparison with myocardial rejection process. Virchows Arch A Pathol Anat Histopathol 423 (1993) 157-160
22. Cunha-Neto E., Bilate A.M., Hyland K.V., et al. Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity 39 (2006) 41-54
23. Ferrari I., Levin M.J., Wallukat G., et al. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. J Exp Med 182 (1995) 59-65
24. Pontes-de-Carvalho L., Santana C.C., Soares M.B., et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. J Autoimmun 18 (2002) 131-138
25. Cunha-Neto E., Duranti M., Gruber A., et al. Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci USA 92 (1995) 3541-3545
26. Cunha-Neto E., Coelho V., Guilherme L., et al. Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. J Clin Invest 98 (1996) 1709-1712
27. Iwai L.K., Juliano M.A., Juliano L., et al. T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun 24 (2005) 111-117
28. Ribeiro A.L., Gimenez L.E., Hernandez C.C., et al. Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease. Int J Cardiol 117 (2007) 59-63
29. Amorim D.S., Godoy R.A., Manco J.C., et al. Effects of acute elevation in blood pressure and of atropine on heart rate in Chagas' disease. A preliminary report. Circulation 38 (1968) 289-294
30. Manco J.C., Gallo Jr. L., Godoy R.A., et al. Degeneration of the cardiac nerves in Chagas' disease. Further studies. Circulation 40 (1969) 879-885
31. Marin-Neto J.A., Gallo Jr. L., Manco J.C., et al. Postural reflexes in chronic Chagas's heart disease. Heart rate and arterial pressure responses. Cardiology 60 (1975) 343-357
32. Junqueira Junior L.F., Gallo J.L., Manco J.C., et al. Subtle cardiac autonomic impairment in Chagas' disease detected by baroreflex sensitivity testing. Braz J Med Biol Res 18 (1985) 171-178
33. Guzzetti S., Iosa D., Pecis M., et al. Impaired heart rate variability in patients with chronic Chagas' disease. Am Heart J 121 (1991) 1727-1734
34. Ribeiro A.L., Moraes R.S., Ribeiro J.P., et al. Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease. Am Heart J 141 (2001) 260-265
35. Machado C.R., Camargos E.R., Guerra L.B., et al. Cardiac autonomic denervation in congestive heart failure: comparison of Chagas' heart disease with other dilated cardiomyopathy. Hum Pathol 31 (2000) 3-10
36. Simoes M.V., Pintya A.O., Bromberg-Marin G., et al. Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas' cardiomyopathy. Am J Cardiol 86 (2000) 975-981
37. Baroldi G., Oliveira S.J., and Silver M.D. Sudden and unexpected death in clinically 'silent' Chagas' disease. A hypothesis. Int J Cardiol 58 (1997) 263-268
38. Marin-Neto J.A., Maciel B.C., Gallo J.L., et al. Effect of parasympathetic impairment on the haemodynamic response to handgrip in Chagas's heart disease. Br Heart J 55 (1986) 204-210
39. Rossi M.A. Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease. Am Heart J 120 (1990) 233-236
40. Rossi M.A., Goncalves S., and Ribeiro-dos-Santos R. Experimental Trypanosoma cruzi cardiomyopathy in BALB/c mice. The potential role of intravascular platelet aggregation in its genesis. Am J Pathol 114 (1984) 209-216
41. Tanowitz H.B., Burns E.R., Sinha A.K., et al. Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Am J Trop Med Hyg 43 (1990) 274-281
42. Tanowitz H.B., Kaul D.K., Chen B., et al. Compromised microcirculation in acute murine Trypanosoma cruzi infection. J Parasitol 82 (1996) 124-130
43. Marin-Neto J.A., Marzullo P., Marcassa C., et al. Myocardial perfusion abnormalities in chronic Chagas' disease as detected by thallium-201 scintigraphy. Am J Cardiol 69 (1992) 780-784
44. Hammermeister K.E., Caeiro T., Crespo E., et al. Left ventricular wall motion in patients with Chagas's disease. Br Heart J 51 (1984) 70-76
45. Ministério da Saúde, Secretaria de Vigilancia em Saúde. Brazilian Consensus on Chagas disease. Rev Soc Bras Med Trop 38 Suppl 3 (2005) 7-29
46. Deborggraeve S., Coronado X., Solari A., et al. T. cruzi OligoC-TesT: a simplified and standardized polymerase chain reaction format for diagnosis of Chagas disease. PLoS Negl Trop Dis 3 (2009) e450
47. Cooley G., Etheridge R.D., Boehlke C., et al. High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Negl Trop Dis 2 (2008) e316
48. Rocha M.O., Ribeiro A.L., and Teixeira M.M. Clinical management of chronic Chagas cardiomyopathy. Front Biosci 8 (2003) e44-e54
49. Ribeiro A.L., and Rocha M.O. Indeterminate form of Chagas disease: considerations about diagnosis and prognosis. Rev Soc Bras Med Trop 31 (1998) 301-314
50. Dias J.C. The indeterminate form of human chronic Chagas' disease. A clinical epidemiological review. Rev Soc Bras Med Trop 22 (1989) 147-156
51. Maguire J.H., Hoff R., Sherlock I., et al. Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community. Circulation 75 (1987) 1140-1145
52. Rocha M.O., Teixeira M.M., and Ribeiro A.L. An update on the management of Chagas cardiomyopathy. Expert Rev Anti Infect Ther 5 (2007) 727-743
53. Rassi Jr. A., Rassi A., and Little W.C. Chagas' heart disease. Clin Cardiol 23 (2000) 883-889
54. Rassi Jr. A., Rassi A., and Rassi S.G. Predictors of mortality in chronic Chagas disease: a systematic review of observational studies. Circulation 115 (2007) 1101-1108
55. Marin-Neto J.A., and Andrade Z.A. Why is there predominance of right heart failure in Chagas' disease?. Arq Bras Cardiol 57 (1991) 181-183
56. Nunes M.C., Barbosa M.M., Brum V.A., et al. Morphofunctional characteristics of the right ventricle in Chagas' dilated cardiomyopathy. Int J Cardiol 94 (2004) 79-85
57. Barros M.V., Machado F.S., Ribeiro A.L., et al. Detection of early right ventricular dysfunction in Chagas' disease using Doppler tissue imaging. J Am Soc Echocardiogr 15 (2002) 1197-1201
58. Marin-Neto J.A., Marzullo P., Sousa A.C., et al. Radionuclide angiographic evidence for early predominant right ventricular involvement in patients with Chagas' disease. Can J Cardiol 4 (1988) 231-236
59. Nunes M.D., Rocha M.O., Ribeiro A.L., et al. Right ventricular dysfunction is an independent predictor of survival in patients with dilated chronic Chagas' cardiomyopathy. Int J Cardiol 127 (2008) 353-359
60. Barros M.V., Machado F.S., Ribeiro A.L., et al. Diastolic function in Chagas' disease: an echo and tissue Doppler imaging study. Eur J Echocardiogr 5 (2004) 182-188
61. Nunes M.C., Barbosa M.M., Ribeiro A.L., et al. Left atrial volume provides independent prognostic value in patients with Chagas cardiomyopathy. J Am Soc Echocardiogr 22 (2009) 82-88
62. Rassi Jr. A., Rassi S.G., and Rassi A. Sudden death in Chagas' disease. Arq Bras Cardiol 76 (2001) 75-96
63. Martinelli F.M., De Siqueira S.F., Moreira H., et al. Probability of occurrence of life-threatening ventricular arrhythmias in Chagas' disease versus non-Chagas' disease. Pacing Clin Electrophysiol 23 (2000) 1944-1946
64. Carrasco H.A., Guerrero L., Parada H., et al. Ventricular arrhythmias and left ventricular myocardial function in chronic chagasic patients. Int J Cardiol 28 (1990) 35-41
65. Sternick E.B., Martinelli M., Sampaio R., et al. Sudden cardiac death in patients with Chagas heart disease and preserved left ventricular function. J Cardiovasc Electrophysiol 17 (2006) 113-116
66. Mota E.A., Guimaraes A.C., Santana O.O., et al. A nine year prospective study of Chagas' disease in a defined rural population in northeast Brazil. Am J Trop Med Hyg 42 (1990) 429-440
67. de Paola A.A., Gomes J.A., Terzian A.B., et al. Ventricular tachycardia during exercise testing as a predictor of sudden death in patients with chronic chagasic cardiomyopathy and ventricular arrhythmias. Br Heart J 74 (1995) 293-295
68. Rassi Jr. A., Rassi A., Little W.C., et al. Development and validation of a risk score for predicting death in Chagas' heart disease. N Engl J Med 355 (2006) 799-808
69. Ribeiro A.L., Cavalvanti P.S., Lombardi F., et al. Prognostic value of signal-averaged electrocardiogram in Chagas disease. J Cardiovasc Electrophysiol 19 (2008) 502-509
70. Ribeiro A.L. Eletrocardiografia na doença de Chagas. Rev Soc Bras Med Trop 27 (1994) 52-54
71. Benchimol-Barbosa P.R., and Barbosa-Filho J. Atrial mechanical remodeling and new onset atrial fibrillation in chronic Chagas' heart disease. Int J Cardiol 127 (2007) e113-e115
72. Espinosa R.A., Pericchi L.R., Carrasco H.A., et al. Prognostic indicators of chronic chagasic cardiopathy. Int J Cardiol 30 (1991) 195-202
73. Ribeiro A.L., Rocha M.O., Barros M.V., et al. A narrow QRS does not predict a normal left ventricular function in Chagas' disease. Pacing Clin Electrophysiol 23 (2000) 2014-2017
74. Ribeiro A.L., Lombardi F., Colosimo E.A., et al. Risk stratification in Chagas disease: further improvements are needed. J Cardiovasc Electrophysiol 19 (2008) E41-E43
75. Rincon L.G., Rocha M.O., Pires M.T., et al. Clinical profile of Chagas and non-Chagas' disease patients with cardiac pacemaker. Rev Soc Bras Med Trop 39 (2006) 245-249
76. Mendoza I., Moleiro F., and Marques J. Sudden death in Chagas' disease. Arq Bras Cardiol 59 (1992) 3-4
77. Nunes M.C., Barbosa M.M., and Rocha M.O. Peculiar aspects of cardiogenic embolism in patients with Chagas' cardiomyopathy: a transthoracic and transesophageal echocardiographic study. J Am Soc Echocardiogr 18 (2005) 761-767
78. Carod-Artal F.J., Vargas A.P., Horan T.A., et al. Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease. Stroke 36 (2005) 965-970
79. Nunes M.C., Barbosa M.M., Ribeiro A.L., et al. Ischemic cerebrovascular events in patients with Chagas cardiomyopathy: a prospective follow-up study. J Neurol Sci 278 (2009) 96-101
80. Carod-Artal F.J., Vargas A.P., Melo M., et al. American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. J Neurol Neurosurg Psychiatry 74 (2003) 516-518
81. Bestetti R.B., Ariolli M.T., do Carmo J.L., et al. Clinical characteristics of acute myocardial infarction in patients with Chagas' disease. Int J Cardiol 35 (1992) 371-376
82. Barros M.V., Costa Rocha M.O., Ribeiro A.L., et al. Tissue Doppler imaging enables the identification of diastolic dysfunction of pseudonormal pattern in Chagas' disease. J Am Soc Echocardiogr 14 (2001) 353-359
83. Barros M.V., Rocha M.O., Ribeiro A.L., et al. Doppler tissue imaging to evaluate early myocardium damage in patients with undetermined form of Chagas' disease and normal echocardiogram. Echocardiography 18 (2001) 131-136
84. Barros M.V., Ribeiro A.L., Machado F.S., et al. Doppler tissue imaging to assess systolic function in Chagas' disease. Arq Bras Cardiol 80 (2003) 36-40
85. Vinicius Lins B.M., Otavio Da Costa R.M., Luiz Pinho R.A., et al. Tissue Doppler imaging in the evaluation of the regional diastolic function in Chagas' disease. Eur J Echocardiogr 2 (2001) 94-99
86. Silva C.E., Ferreira L.D., Peixoto L.B., et al. Evaluation of segmentary contractility in Chagas' disease by using the integral of the myocardial velocity gradient (myocardial strain) obtained through tissue Doppler echocardiography. Arq Bras Cardiol 84 (2005) 285-291
87. Carrasco H.A., Parada H., Guerrero L., et al. Prognostic implications of clinical, electrocardiographic and hemodynamic findings in chronic Chagas' disease. Int J Cardiol 43 (1994) 27-38
88. Mady C., Cardoso R.H., Barretto A.C., et al. Survival and predictors of survival in patients with congestive heart failure due to Chagas' cardiomyopathy. Circulation 90 (1994) 3098-3102
89. Salles G., Xavier S., Sousa A., et al. Prognostic value of QT interval parameters for mortality risk stratification in Chagas' disease: results of a long-term follow-up study. Circulation 108 (2003) 305-312
90. Viotti R., Vigliano C., Lococo B., et al. Clinical predictors of chronic chagasic myocarditis progression. Rev Esp Cardiol 58 (2005) 1037-1044
91. Perez AA, Ribeiro AL, Barros MV, et al: Value of the radiological study of the thorax for diagnosing left ventricular dysfunction in Chagas' disease. Arq Bras Cardiol 2003;80:208-213, 202-207.
92. Barbosa M.M., Nunes M.D., Ribeiro A.L., et al. N-terminal proBNP levels in patients with Chagas disease: a marker of systolic and diastolic dysfunction of the left ventricle. Eur J Echocardiogr 8 (2006) 204-212
93. Ribeiro A.L., dos Reis A.M., Barros M.V., et al. Brain natriuretic peptide and left ventricular dysfunction in Chagas' disease. Lancet 360 (2002) 461-462
94. Ribeiro A.L., Reis A.M., Teixeira M.M., et al. Brain natriuretic peptide in Chagas' disease: further insights. Lancet 362 (2003) 333
95. Ribeiro A.L., Teixeira M.M., Reis A.M., et al. Brain natriuretic peptide based strategy to detect left ventricular dysfunction in Chagas disease: a comparison with the conventional approach. Int J Cardiol 109 (2006) 34-40
96. Talvani A., Rocha M.O., Cogan J., et al. Brain natriuretic peptide and left ventricular dysfunction in chagasic cardiomyopathy. Mem Inst Oswaldo Cruz 99 (2004) 645-649
97. Talvani A., Rocha M.O., Cogan J., et al. Brain natriuretic peptide measurement in Chagas heart disease: marker of ventricular dysfunction and arrhythmia. Int J Cardiol 100 (2005) 503-504
98. Oliveira B.M., Botoni F.A., Ribeiro A.L., et al. Correlation between BNP levels and Doppler echocardiographic parameters of left ventricle filling pressure in patients with chagasic cardiomyopathy. Echocardiography 26 (2009) 521-527
99. Grupi C.J., Moffa P.J., Barbosa S.A., et al. Holter monitoring in Chagas' heart disease. Sao Paulo Med J 113 (1995) 835-840
100. Martinelli F.M., Sosa E., Nishioka S., et al. Clinical and electrophysiologic features of syncope in chronic chagasic heart disease. J Cardiovasc Electrophysiol 5 (1994) 563-570
101. Ribeiro A.L., Lombardi F., Sousa M.R., et al. Power-law behavior of heart rate variability in Chagas' disease. Am J Cardiol 89 (2002) 414-418
102. Ribeiro A.L., Lombardi F., Sousa M.R., et al. Vagal dysfunction in Chagas disease. Int J Cardiol 103 (2005) 225-226
103. Ribeiro A.L., Schmidt G., Sousa M.R., et al. Heart rate turbulence in Chagas disease. Pacing Clin Electrophysiol 26 (2003) 406-410
104. Tundo F., Lombardi F., Rocha M.C., et al. Heart rate turbulence and left ventricular ejection fraction in Chagas disease. Europace 7 (2005) 197-203
105. Leite L.R., Fenelon G., Simoes Jr. A., et al. Clinical usefulness of electrophysiologic testing in patients with ventricular tachycardia and chronic chagasic cardiomyopathy treated with amiodarone or sotalol. J Cardiovasc Electrophysiol 14 (2003) 567-573
106. Silva R.M., Tavora M.Z., Gondim F.A., et al. Predictive value of clinical and electrophysiological variables in patients with chronic chagasic cardiomyopathy and nonsustained ventricular tachycardia. Arq Bras Cardiol 75 (2000) 33-47
107. Rocha A.L., Rocha M.O., Teixeira B.O., et al. Chronotropic-metabolic index in Chagas' disease. Rev Soc Bras Med Trop 38 (2005) 373-376
108. Rocha A.L., Lombardi F., Costa Rocha M.O., et al. Chronotropic incompetence and abnormal autonomic modulation in ambulatory Chagas disease patients. Ann Noninvasive Electrocardiol 11 (2006) 3-11
109. Simoes M.V., Ayres E.M., Santos J.L., et al. Detection of myocardial ischemia in chronic Chagas disease patients with atypic precordial pain by exercise and Holter tests. Arq Bras Cardiol 60 (1993) 315-319
110. Rochitte C.E., Nacif M.S., Oliveira Junior A.C., et al. Cardiac magnetic resonance in Chagas' disease. Artif Organs 31 (2007) 259-267
111. Rochitte C.E., Oliveira P.F., Andrade J.M., et al. Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas' disease: a marker of disease severity. J Am Coll Cardiol 46 (2005) 1553-1558
112. Kuschnir E., Sgammini H., Castro R., et al. Evaluation of cardiac function by radioisotopic angiography, in patients with chronic Chagas cardiopathy. Arq Bras Cardiol 45 (1985) 249-256
113. Viotti R., Vigliano C., Lococo B., et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med 144 (2006) 724-734
114. Benchimol Barbosa P.R. Noninvasive prognostic markers for cardiac death and ventricular arrhythmia in long-term follow-up of subjects with chronic Chagas' disease. Braz J Med Biol Res 40 (2007) 167-178
115. Hunt S.A., Abraham W.T., Chin M.H., et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 112 (2005) e154-e235
116. Bocchi E.A., Vilas-Boas F., Perrone S., et al. Latin American guidelines for the assessment and management of decompensated heart failure. Arq Bras Cardiol 85 Suppl 3 (2005) 49-94
117. Salles G.F., Xavier S.S., Sousa A.S., et al. T-wave axis deviation as an independent predictor of mortality in chronic Chagas' disease. Am J Cardiol 93 (2004) 1136-1140
118. Rocha M.O., and Ribeiro A.L. A risk score for predicting death in Chagas' heart disease. N Engl J Med 355 (2006) 2488-2489
119. Kalil J., and Cunha-Neto E. Autoimmunity in Chagas disease cardiomyopathy: fulfilling the criteria at last?. Parasitol Today 12 (1996) 396-399
120. Cunha-Neto E., Teixeira P.C., Nogueira L.G., et al. New concepts on the pathogenesis of chronic Chagas cardiomyopathy: myocardial gene and protein expression profiles. Rev Soc Bras Med Trop 39 Suppl 3 (2006) 59-62
121. Jones E.M., Colley D.G., Tostes S., et al. A Trypanosoma cruzi DNA sequence amplified from inflammatory lesions in human chagasic cardiomyopathy. Trans Assoc Am Physicians 105 (1992) 182-189
122. de Andrade A.L., Zicker F., de Oliveira R.M., et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 348 (1996) 1407-1413
123. Rassi A., Rassi Jr. A., and Rassi G.G. Fase aguda. In: Brener Z., Andrade Z.A., and Barral-Netto M. (Eds). Trypanosoma cruzi e doença de Chagas (2000), Guanabara-Koogan, Brazil 231-245
124. Sosa E.S., Segura E.L., Ruiz A.M., et al. Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease. Am J Trop Med Hyg 59 (1998) 526-529
125. Villar J.C., Marin-Neto J.A., Ebrahim S., et al. Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection. Cochrane Database Syst Rev (2002) CD003463
126. Yun O., Lima M.A., Ellman T., et al. Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins Sans Frontieres. PLoS Negl Trop Dis 3 (2009) e488
127. Viotti R., Vigliano C., Lococo B., et al. Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities. Expert Rev Anti Infect Ther 7 (2009) 157-163
128. Franco-Paredes C., Bottazzi M.E., and Hotez P.J. The unfinished public health agenda of Chagas disease in the era of globalization. PLoS Negl Trop Dis 3 (2009) e470
129. Ribeiro I., Sevcsik A.M., Alves F., et al. New, improved treatments for Chagas disease: from the r and d pipeline to the patients. PLoS Negl Trop Dis 3 (2009) e484
130. Marin-Neto J.A., Rassi Jr. A., Morillo C.A., et al. Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). Am Heart J 156 (2008) 37-43
131. Marin-Neto J.A., Rassi Jr. A., Avezum Jr. A., et al. The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease. Mem Inst Oswaldo Cruz 104 (2009) 319-324
132. Roberti R.R., Martinez E.E., Andrade J.L., et al. Chagas cardiomyopathy and captopril. Eur Heart J 13 (1992) 966-970
133. Szajnbok F.E., Barretto A.C., Mady C., et al. Beneficial effects of enalapril on the diastolic ventricular function in Chagas myocardiopathy. Arq Bras Cardiol 60 (1993) 273-278
134. Davila D.F., Angel F., Arata d.B., et al. Effects of metoprolol in chagasic patients with severe congestive heart failure. Int J Cardiol 85 (2002) 255-260
135. Botoni F.A., Poole-Wilson P.A., Ribeiro A.L., et al. A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy. Am Heart J 153 (2007) 544-548
136. Braga J.C., Reis F., Aras R., et al. Clinical and therapeutics aspects of heart failure due to Chagas disease. Arq Bras Cardiol 86 (2006) 297-302
137. Bestetti R.B., and Muccillo G. Clinical course of Chagas' heart disease: a comparison with dilated cardiomyopathy. Int J Cardiol 60 (1997) 187-193
138. Bestetti R.B., Sales-Neto V.N., Pinto L.Z., et al. Effects of long term metoprolol administration on the electrocardiogram of rats infected with T cruzi. Cardiovasc Res 24 (1990) 521-527
139. Bestetti R.B., Theodoropoulos T.A., Cardinalli-Neto A., et al. Treatment of chronic systolic heart failure secondary to Chagas heart disease in the current era of heart failure therapy. Am Heart J 156 (2008) 422-430
140. Botoni F.A., Poole-Wilson P.A., Ribeiro A.L., et al. Treating Chagas' cardiomyopathy patients with chronic heart failure. Am Heart J e33 (2007) 154
141. Khoury A.M., Davila D.F., Bellabarba G., et al. Acute effects of digitalis and enalapril on the neurohormonal profile of chagasic patients with severe congestive heart failure. Int J Cardiol 57 (1996) 21-29
142. Bestetti R.B., and Rossi M.A. A rationale approach for mortality risk stratification in Chagas' heart disease. Int J Cardiol 58 (1997) 199-209
143. de Sousa A.S., Xavier S.S., de Freitas G.R., et al. Prevention strategies of cardioembolic ischemic stroke in Chagas' disease. Arq Bras Cardiol 91 (2008) 306-310
144. Rassi J.A., Gabriel R.A., Gabriel R.S., et al. Ventricular arrhythmia in Chagas disease. Diagnostic, prognostic, and therapeutic features. Arq Bras Cardiol 65 (1995) 377-387
145. Rosa R.F., Neto A.S., and Franken R.A. Chagas' disease and the use of implantable cardioverter-defibrillators in Brazil. Am J Geriatr Cardiol 15 (2006) 372-376
146. Cardinalli-Neto A., Greco O.T., and Bestetti R.B. Automatic implantable cardioverter-defibrillators in Chagas' heart disease patients with malignant ventricular arrhythmias. Pacing Clin Electrophysiol 29 (2006) 467-470
147. Cardinalli-Neto A., Bestetti R.B., Cordeiro J.A., et al. Predictors of all-cause mortality for patients with chronic Chagas' heart disease receiving implantable cardioverter defibrillator therapy. J Cardiovasc Electrophysiol 18 (2007) 1236-1240
148. Doval H.C., Nul D.R., Grancelli H.O., et al. Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA). Lancet 344 (1994) 493-498
149. Bocchi E.A., and Fiorelli A. The Brazilian experience with heart transplantation: a multicenter report. J Heart Lung Transplant 20 (2001) 637-645
150. Parra A.V., Rodrigues V., Cancella S., et al. Impact of socioeconomic status on outcome of a Brazilian heart transplant recipients cohort. Int J Cardiol 125 (2008) 142-143
151. Theodoropoulos T.A., Bestetti R.B., Otaviano A.P., et al. Predictors of all-cause mortality in chronic Chagas' heart disease in the current era of heart failure therapy. Int J Cardiol 128 (2008) 22-29
152. Bocchi E.A., and Fiorelli A. The paradox of survival results after heart transplantation for cardiomyopathy caused by Trypanosoma cruzi. First Guidelines Group for Heart Transplantation of the Brazilian Society of Cardiology. Ann Thorac Surg 71 (2001) 1833-1838
153. Sartori A.M., Ibrahim K.Y., Nunes Westphalen E.V., et al. Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS. Ann Trop Med Parasitol 101 (2007) 31-50
154. Sartori A.M., Neto J.E., Nunes E.V., et al. Trypanosoma cruzi parasitemia in chronic Chagas disease: comparison between human immunodeficiency virus (HIV)-positive and HIV-negative patients. J Infect Dis 186 (2002) 872-875
155. de Carvalho V.B., Sousa E.F., Vila J.H., et al. Heart transplantation in Chagas' disease. 10 years after the initial experience. Circulation 94 (1996) 1815-1817
156. Bocchi E.A., Bellotti G., Mocelin A.O., et al. Heart transplantation for chronic Chagas' heart disease. Ann Thorac Surg 61 (1996) 1727-1733
157. Bestetti R.B., Souza T.R., Lima M.F., et al. Effects of a mycophenolate mofetil-based immunosuppressive regimen in Chagas' heart transplant recipients. Transplantation 84 (2007) 441-442
158. de Souza M.M., Franco M., Almeida D.R., et al. Comparative histopathology of endomyocardial biopsies in chagasic and non-chagasic heart transplant recipients. J Heart Lung Transplant 20 (2001) 534-543
159. Fiorelli A.I., Stolf N.A., Honorato R., et al. Later evolution after cardiac transplantation in Chagas' disease. Transplant Proc 37 (2005) 2793-2798
160. Rassi Jr. A., Dias J.C., Marin-Neto J.A., et al. Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas disease. Heart 95 (2009) 524-534
161. Senior K. Chagas disease: moving towards global elimination. Lancet Infect Dis 7 (2007) 572
162. Centers for Disease Control and Prevention. Blood donor screening for Chagas disease: United States, 2006-2007. MMWR Morb Mortal WklyRep 56 (2007) 141-143