Multiplicity-Dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway

Virology

Volumn 435, Issue 2, 2013, Pages 250-257

  McCormick, A Louise ^a,b   Roback, Linda ^a   Wynn, Grace ^a   Mocarski, Edward S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDIMMUNE   (United States)

Author keywords

Apoptosis; Cytomegalovirus; Herpesvirus; HtrA2 Omi; ROS; Serine protease cell death

Indexed keywords

BUTYLATED HYDROXYANISOLE; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE; TOSYLLYSYL CHLOROMETHYL KETONE; VIRUS DNA; VIRUS ENZYME;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS INFECTION; VIRUS REPLICATION;

APOPTOSIS; CELL DEATH; CELLS, CULTURED; CYTOMEGALOVIRUS; CYTOPATHOGENIC EFFECT, VIRAL; FIBROBLASTS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; VIRAL PROTEINS; VIRUS REPLICATION;

CYTOMEGALOVIRUS; HERPESVIRIDAE;

EID: 84871700981     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2012.08.042     Document Type: Article

References (32)

1. Barber G.N. Host defense, viruses and apoptosis. Cell Death Differ. 2001, 8:113-126.
2. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011, 157:144-150.
3. Carpenter A.E., Jones T.R., Lamprecht M.R., Clarke C., Kang I.H., Friman O., Guertin D.A., Chang J.H., Lindquist R.A., Moffat J., Golland P., Sabatini D.M. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006, 7:R100.
4. Cicin-Sain L., Ruzsics Z., Podlech J., Bubic I., Menard C., Jonjic S., Reddehase M.J., Koszinowski U.H. Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene. J. Virol. 2008, 82:2056-2064.
5. Dunn W., Chou C., Li H., Hai R., Patterson D., Stolc V., Zhu H., Liu F. Functional profiling of a human cytomegalovirus genome. Proc. Natl. Acad. Sci., USA 2003, 100:14223-14228.
6. Hamanaka R.B., Chandel N.S. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem. Sci. 2010, 35:505-513.
7. Holley A.K., Dhar S.K., Clair D.K. Manganese superoxide dismutase vs. p53: regulation of mitochondrial ROS. Mitochondrion 2010, 10:649-661.
8. Kaarbo M., Ager-Wick E., Osenbroch P.O., Kilander A., Skinnes R., Muller F., Eide L. Human cytomegalovirus infection increases mitochondrial biogenesis. Mitochondrion 2011, 11:935-945.
9. Kim S.J., Varghese T.K., Zhang Z., Zhao L.C., Thomas G., Hummel M., Abecassis M. Renal ischemia/reperfusion injury activates the enhancer domain of the human cytomegalovirus major immediate early promoter. Am. J. Transplant. 2005, 5:1606-1613.
10. Krick S., Shi S., Ju W., Faul C., Tsai S.Y., Mundel P., Bottinger E.P. Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease. Proc. Natl. Acad. Sci., USA 2008, 105:14106-14111.
11. Krishna S., Low I.C., Pervaiz S. Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. Biochem. J. 2011, 435:545-551.
12. Lamkanfi M., Dixit V.M. Manipulation of host cell death pathways during microbial infections. Cell Host Microbe 2010, 8:44-54.
13. McCormick A.L. Control of apoptosis by human cytomegalovirus. Curr. Top. Microbiol. Immunol. 2008, 325:281-295.
14. McCormick A.L., Meiering C.D., Smith G.B., Mocarski E.S. Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis. J. Virol. 2005, 79:12205-12217.
15. McCormick A.L., Roback L., Livingston-Rosanoff D., Clair C. The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages. J. Virol. 2010, 84:5108-5123.
16. McCormick A.L., Roback L., Mocarski E.S. HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). Plos Pathog. 2008, 4:e1000063.
17. Menard C., Wagner M., Ruzsics Z., Holak K., Brune W., Campbell A.E., Koszinowski U.H. Role of murine cytomegalovirus US22 gene family members in replication in macrophages. J. Virol. 2003, 77:5557-5570.
18. Mocarski E.S., Upton J.W., Kaiser W.J. Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat. Rev. Immunol. 2011, 12:79-88.
19. Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
20. Poncet D., Pauleau A.L., Szabadkai G., Vozza A., Scholz S.R., Le Bras M., Briere J.J., Jalil A., Le Moigne R., Brenner C., Hahn G., Wittig I., Schagger H., Lemaire C., Bianchi K., Souquere S., Pierron G., Rustin P., Goldmacher V.S., Rizzuto R., Palmieri F., Kroemer G. Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. J. Cell Biol. 2006, 174:985-996.
21. Reboredo M., Greaves R.F., Hahn G. Human cytomegalovirus proteins encoded by UL37 exon 1 protect infected fibroblasts against virus-induced apoptosis and are required for efficient virus replication. J. Gen. Virol. 2004, 85:3555-3567.
22. Reeves M.B., Davies A.A., McSharry B.P., Wilkinson G.W., Sinclair J.H. Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 2007, 316:1345-1348.
23. Seo J.Y., Yaneva R., Hinson E.R., Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science 2011, 332:1093-1097.
24. Sharon-Friling R., Goodhouse J., Colberg-Poley A.M., Shenk T. Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores. Proc. Natl. Acad. Sci., USA 2006, 103:19117-19122.
25. Skaletskaya A., Bartle L.M., Chittenden T., McCormick A.L., Mocarski E.S., Goldmacher V.S. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc. Natl. Acad. Sci., USA 2001, 98:7829-7834.
26. Speir E. Cytomegalovirus gene regulation by reactive oxygen species. Agents in atherosclerosis. Ann. N. Y. Acad. Sci. 2000, 899:363-374.
27. Stinski M.F., Mocarski E.S., Thomsen D.R. DNA of human cytomegalovirus: size heterogeneity and defectiveness resulting from serial undiluted passage. J. Virol. 1979, 31:231-239.
28. Tilton C., Clippinger A.J., Maguire T., Alwine J.C. Human cytomegalovirus induces multiple means to combat reactive oxygen species. J. Virol. 2011, 85:12585-12593.
29. Upton J.W., Kaiser W.J., Mocarski E.S. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010, 7:302-313.
30. Upton J.W., Kaiser W.J., Mocarski E.S. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 2012, 11:290-297.
31. Vande Walle L., Lamkanfi M., Vandenabeele P. The mitochondrial serine protease HtrA2/Omi: an overview. Cell Death Differ. 2008, 15:453-460.
32. Zhu H., Cong J.P., Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc. Natl. Acad. Sci., USA 1997, 94:13985-13990.