-
1
-
-
58149463874
-
Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription
-
Amano T., Sagai T., Tanabe H., Mizushina Y., Nakazawa H., Shiroishi T. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev. Cell 2009, 16:47-57.
-
(2009)
Dev. Cell
, vol.16
, pp. 47-57
-
-
Amano, T.1
Sagai, T.2
Tanabe, H.3
Mizushina, Y.4
Nakazawa, H.5
Shiroishi, T.6
-
2
-
-
27144531386
-
Germline mutations in HRAS proto-oncogene cause Costello syndrome
-
Aoki Y., Niihori T., Kawame H., Kurosawa K., Ohashi H., Tanaka Y., Filocamo M., Kato K., Suzuki Y., Kure S., Matsubara Y. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nat. Genet. 2005, 37:1038-1040.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1038-1040
-
-
Aoki, Y.1
Niihori, T.2
Kawame, H.3
Kurosawa, K.4
Ohashi, H.5
Tanaka, Y.6
Filocamo, M.7
Kato, K.8
Suzuki, Y.9
Kure, S.10
Matsubara, Y.11
-
3
-
-
71949105991
-
Longitudinal course of cognitive, adaptive, and behavioral characteristics in Costello syndrome
-
Axelrad M.E., Schwartz D.D., Fehlis J.E., Hopkins E., Stabley D.L., Sol-Church K., Gripp K.W. Longitudinal course of cognitive, adaptive, and behavioral characteristics in Costello syndrome. Am. J. Med. Genet. A 2009, 149A:2666-2672.
-
(2009)
Am. J. Med. Genet. A
, vol.149 A
, pp. 2666-2672
-
-
Axelrad, M.E.1
Schwartz, D.D.2
Fehlis, J.E.3
Hopkins, E.4
Stabley, D.L.5
Sol-Church, K.6
Gripp, K.W.7
-
4
-
-
34249669335
-
Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene
-
Bertola D.R., Pereira A.C., Brasil A.S., Albano L.M., Kim C.A., Krieger J.E. Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. J. Hum. Genet. 2007, 52:521-526.
-
(2007)
J. Hum. Genet.
, vol.52
, pp. 521-526
-
-
Bertola, D.R.1
Pereira, A.C.2
Brasil, A.S.3
Albano, L.M.4
Kim, C.A.5
Krieger, J.E.6
-
5
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G., Hirth P., Tsai J., Zhang J., Ibrahim P.N., Cho H., Spevak W., Zhang C., Zhang Y., Habets G., Burton E.A., Wong B., Tsang G., West B.L., Powell B., Shellooe R., Marimuthu A., Nguyen H., Zhang K.Y.J., Artis D.R., Schlessinger J., Su F., Higgins B., Iyer R., D'Andrea K., Koehler A., Stumm M., Lin P.S., Lee R.J., Grippo J., Puzanov I., Kim K.B., Ribas A., McArthur G.A., Sosman J.A., Chapman P.B., Flaherty K.T., Xu X., Nathanson K.L., Nolop K. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467:596-599.
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
Spevak, W.7
Zhang, C.8
Zhang, Y.9
Habets, G.10
Burton, E.A.11
Wong, B.12
Tsang, G.13
West, B.L.14
Powell, B.15
Shellooe, R.16
Marimuthu, A.17
Nguyen, H.18
Zhang, K.Y.J.19
Artis, D.R.20
Schlessinger, J.21
Su, F.22
Higgins, B.23
Iyer, R.24
D'Andrea, K.25
Koehler, A.26
Stumm, M.27
Lin, P.S.28
Lee, R.J.29
Grippo, J.30
Puzanov, I.31
Kim, K.B.32
Ribas, A.33
McArthur, G.A.34
Sosman, J.A.35
Chapman, P.B.36
Flaherty, K.T.37
Xu, X.38
Nathanson, K.L.39
Nolop, K.40
more..
-
6
-
-
8444223854
-
Requirement of the forkhead gene Foxe1, a target of Sonic Hedgehog signaling, in hair follicle morphogenesis
-
Brancaccio A., Minichiello A., Grachtchouk M., Antonini D., Sheng H., Parlato R., Dathan N., Dlugosz A.A., Missero C. Requirement of the forkhead gene Foxe1, a target of Sonic Hedgehog signaling, in hair follicle morphogenesis. Hum. Mol. Genet. 2004, 13:2595-2606.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2595-2606
-
-
Brancaccio, A.1
Minichiello, A.2
Grachtchouk, M.3
Antonini, D.4
Sheng, H.5
Parlato, R.6
Dathan, N.7
Dlugosz, A.A.8
Missero, C.9
-
7
-
-
0032953901
-
Essential role for Sonic Hedgehog during hair follicle morphogenesis
-
Chiang C., Swan R.Z., Grachtchouk M., Bolinger M., Litingtung Y., Robertson E.K., Cooper M.K., Gaffield W., Westphal H., Beachy P.A., Dlugosz A.A. Essential role for Sonic Hedgehog during hair follicle morphogenesis. Dev. Biol. 1999, 205:1-9.
-
(1999)
Dev. Biol.
, vol.205
, pp. 1-9
-
-
Chiang, C.1
Swan, R.Z.2
Grachtchouk, M.3
Bolinger, M.4
Litingtung, Y.5
Robertson, E.K.6
Cooper, M.K.7
Gaffield, W.8
Westphal, H.9
Beachy, P.A.10
Dlugosz, A.A.11
-
8
-
-
0142074405
-
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
-
Corson L.B., Yamanaka Y., Lai K.M., Rossant J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 2003, 130:4527-4537.
-
(2003)
Development
, vol.130
, pp. 4527-4537
-
-
Corson, L.B.1
Yamanaka, Y.2
Lai, K.M.3
Rossant, J.4
-
9
-
-
33845292259
-
A negative feedback signaling network underlies oncogene-induced senescence
-
Courtois-Cox S., Genther Williams S.M., Reczek E.E., Johnson B.W., McGillicuddy L.T., Johannessen C.M., Hollstein P.E., MacCollin M., Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006, 10:459-472.
-
(2006)
Cancer Cell
, vol.10
, pp. 459-472
-
-
Courtois-Cox, S.1
Genther Williams, S.M.2
Reczek, E.E.3
Johnson, B.W.4
McGillicuddy, L.T.5
Johannessen, C.M.6
Hollstein, P.E.7
MacCollin, M.8
Cichowski, K.9
-
10
-
-
0029917507
-
Fibroblast growth factor receptor 3 is a negative regulator of bone growth
-
Deng C., Wynshaw-Boris A., Zhou F., Kuo A., Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996, 84:911-921.
-
(1996)
Cell
, vol.84
, pp. 911-921
-
-
Deng, C.1
Wynshaw-Boris, A.2
Zhou, F.3
Kuo, A.4
Leder, P.5
-
11
-
-
0037264633
-
Targeting RAS signaling pathways in cancer therapy
-
Downward J. Targeting RAS signaling pathways in cancer therapy. Nat. Rev. 2003, 3:11-22.
-
(2003)
Nat. Rev.
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
12
-
-
0842264188
-
Fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
-
Dubrulle J., Pourquié O. Fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature 2004, 427:419-422.
-
(2004)
Nature
, vol.427
, pp. 419-422
-
-
Dubrulle, J.1
Pourquié, O.2
-
13
-
-
0032915095
-
Regionalization of Sonic Hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms
-
Epstein D.J., McMahon A.P., Joyner A.L. Regionalization of Sonic Hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development 1999, 126:281-292.
-
(1999)
Development
, vol.126
, pp. 281-292
-
-
Epstein, D.J.1
McMahon, A.P.2
Joyner, A.L.3
-
14
-
-
0035038659
-
The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain
-
Etchevers H.C., Vincent C., Le Douarin N.M., Couly G.F. The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development 2001, 128:1059-1068.
-
(2001)
Development
, vol.128
, pp. 1059-1068
-
-
Etchevers, H.C.1
Vincent, C.2
Le Douarin, N.M.3
Couly, G.F.4
-
15
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase
-
Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase. J. Biol. Chem. 1998, 273:18623-18632.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
Copeland, R.A.11
Magolda, R.L.12
Scherle, P.A.13
Trzaskos, J.M.14
-
16
-
-
58949102946
-
A two-step mechanism for stem cell activation during hair regeneration
-
Greco V., Chen T., Rendl M., Schober M., Pasolli H.A., Stokes N., Dela Cruz-Racelis J., Fuchs E. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 2009, 4:155-169.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 155-169
-
-
Greco, V.1
Chen, T.2
Rendl, M.3
Schober, M.4
Pasolli, H.A.5
Stokes, N.6
Dela Cruz-Racelis, J.7
Fuchs, E.8
-
17
-
-
77951745198
-
High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities
-
Gripp K.W., Hopkins E., Doyle D., Dobyns W.B. High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities. Am. J. Med. Genet. A 2010, 152A:1161-1168.
-
(2010)
Am. J. Med. Genet. A
, vol.152 A
, pp. 1161-1168
-
-
Gripp, K.W.1
Hopkins, E.2
Doyle, D.3
Dobyns, W.B.4
-
18
-
-
33947141532
-
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
-
Grose R., Fantl V., Werner S., Chioni A.-M., Jarosz M., Rudling R., Cross B., Hart I.R., Dickson C. The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J. 2007, 26:1268-1278.
-
(2007)
EMBO J.
, vol.26
, pp. 1268-1278
-
-
Grose, R.1
Fantl, V.2
Werner, S.3
Chioni, A.-M.4
Jarosz, M.5
Rudling, R.6
Cross, B.7
Hart, I.R.8
Dickson, C.9
-
19
-
-
34047146873
-
Tristetraprolin recruits functional mRNA decay complexes to are sequences
-
Hau H.H., Walsh R.J., Ogilvie R.L., Williams D.A., Reilly C.S., Bohjanen P.R. Tristetraprolin recruits functional mRNA decay complexes to are sequences. J. Cell. Biochem. 2007, 100:1477-1492.
-
(2007)
J. Cell. Biochem.
, vol.100
, pp. 1477-1492
-
-
Hau, H.H.1
Walsh, R.J.2
Ogilvie, R.L.3
Williams, D.A.4
Reilly, C.S.5
Bohjanen, P.R.6
-
20
-
-
0038713378
-
MKP3 mediates the cellular response to FGF8 signaling in the vertebrate limb
-
Kawakami Y., Rodriguez-Leon J., Koth C.M., Buscher D., Itoh T., Raya A., Ng J.K., Esteban C.R., Takahashi S., Henrique D., Schwarz M.F., Asahara H., Izpisua Belmonte J.C. MKP3 mediates the cellular response to FGF8 signaling in the vertebrate limb. Nat. Cell Biol. 2003, 5:513-519.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 513-519
-
-
Kawakami, Y.1
Rodriguez-Leon, J.2
Koth, C.M.3
Buscher, D.4
Itoh, T.5
Raya, A.6
Ng, J.K.7
Esteban, C.R.8
Takahashi, S.9
Henrique, D.10
Schwarz, M.F.11
Asahara, H.12
Izpisua Belmonte, J.C.13
-
21
-
-
17144460676
-
The discovery of potent cRaf1 kinase inhibitors
-
Lackey K., Cory M., Davis R., Frye S.V., Harris P.A., Hunter R.N., Jung D.K., McDonald O.B., McNutt R.W., Peel M.R., Rutkowske R.D., Veal J.M., Wood E.R. The discovery of potent cRaf1 kinase inhibitors. Bioorg. Med. Chem. Lett. 2000, 10:223-226.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 223-226
-
-
Lackey, K.1
Cory, M.2
Davis, R.3
Frye, S.V.4
Harris, P.A.5
Hunter, R.N.6
Jung, D.K.7
McDonald, O.B.8
McNutt, R.W.9
Peel, M.R.10
Rutkowske, R.D.11
Veal, J.M.12
Wood, E.R.13
-
22
-
-
0033673531
-
Fgf8 signaling from the AER is essential for normal limb development
-
Lewandoski M., Sun X., Martin G.R. Fgf8 signaling from the AER is essential for normal limb development. Nat. Genet. 2000, 26:460-463.
-
(2000)
Nat. Genet.
, vol.26
, pp. 460-463
-
-
Lewandoski, M.1
Sun, X.2
Martin, G.R.3
-
23
-
-
0035368725
-
Cholesterol modification of Sonic Hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
-
Lewis P.M., Dunn M.P., McMahon J.A., Logan M., Martin J.F., St-Jacques B., McMahon A.P. Cholesterol modification of Sonic Hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001, 105:599-612.
-
(2001)
Cell
, vol.105
, pp. 599-612
-
-
Lewis, P.M.1
Dunn, M.P.2
McMahon, J.A.3
Logan, M.4
Martin, J.F.5
St-Jacques, B.6
McMahon, A.P.7
-
24
-
-
79952017072
-
Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: A Ras/MAPK pathway syndrome
-
Lin A.E., Alexander M.E., Colan S.D., Kerr B., Rauen K.A., Noonan J., Baffa J., Hopkins E., Sol-Church K., Limongelli G., Digilio M.C., Marino B., Innes A.M., Aoki Y., Silberbach M., Delrue M.-A., White S.M., Hamilton R.M., O'Connor W., Grossfeld P.D., Smoot L.B., Padera R.F., Gripp K.W. Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: A Ras/MAPK pathway syndrome. Amer. J. Med. Genet. Part A 2011, 155A(3):486-507.
-
(2011)
Amer. J. Med. Genet. Part A
, vol.155 A
, Issue.3
, pp. 486-507
-
-
Lin, A.E.1
Alexander, M.E.2
Colan, S.D.3
Kerr, B.4
Rauen, K.A.5
Noonan, J.6
Baffa, J.7
Hopkins, E.8
Sol-Church, K.9
Limongelli, G.10
Digilio, M.C.11
Marino, B.12
Innes, A.M.13
Aoki, Y.14
Silberbach, M.15
Delrue, M.-A.16
White, S.M.17
Hamilton, R.M.18
O'Connor, W.19
Grossfeld, P.D.20
Smoot, L.B.21
Padera, R.F.22
Gripp, K.W.23
more..
-
26
-
-
64549154822
-
Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb
-
Mao J., McGlinn E., Huang P., Tabin C.J., McMahon A.P. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev. Cell 2009, 16:600-606.
-
(2009)
Dev. Cell
, vol.16
, pp. 600-606
-
-
Mao, J.1
McGlinn, E.2
Huang, P.3
Tabin, C.J.4
McMahon, A.P.5
-
27
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
-
Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
28
-
-
1942470024
-
Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
-
Meijering E., Jacob M., Sarria J.C., Steiner P., Hirling H., Unser M. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A 2004, 58:167-176.
-
(2004)
Cytometry A
, vol.58
, pp. 167-176
-
-
Meijering, E.1
Jacob, M.2
Sarria, J.C.3
Steiner, P.4
Hirling, H.5
Unser, M.6
-
29
-
-
0037439152
-
Sonic Hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
-
Mill P., Mo R., Fu H., Grachtchouk M., Kim P.C.W., Dlugosz A.A., Hui C.-C. Sonic Hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 2003, 17:282-294.
-
(2003)
Genes Dev.
, vol.17
, pp. 282-294
-
-
Mill, P.1
Mo, R.2
Fu, H.3
Grachtchouk, M.4
Kim, P.C.W.5
Dlugosz, A.A.6
Hui, C.-C.7
-
30
-
-
78651380657
-
Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling
-
Mukhopadhyay A., Krishnaswami S.R., Yu B.D.Y. Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling. J. Invest. Dermatol. 2011, 131:311-319.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 311-319
-
-
Mukhopadhyay, A.1
Krishnaswami, S.R.2
Yu, B.D.Y.3
-
31
-
-
0036051342
-
Molecular interpretation of ERK signal duration by immediate early gene products
-
Murphy L.O., Smith S., Chen R.H., Fingar D.C., Blenis J. Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 2002, 4:556-564.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 556-564
-
-
Murphy, L.O.1
Smith, S.2
Chen, R.H.3
Fingar, D.C.4
Blenis, J.5
-
32
-
-
0038467389
-
Stimulation of ectodermal organ development by Ectodysplasin-A1
-
Mustonen T., Pispa J., Mikkola M.L., Pummila M., Kangas A.T., Pakkasjarvi L., Jaatinen R., Thesleff I. Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev. Biol. 2003, 259:123-136.
-
(2003)
Dev. Biol.
, vol.259
, pp. 123-136
-
-
Mustonen, T.1
Pispa, J.2
Mikkola, M.L.3
Pummila, M.4
Kangas, A.T.5
Pakkasjarvi, L.6
Jaatinen, R.7
Thesleff, I.8
-
33
-
-
33947147117
-
Noonan syndrome and related disorders: alterations in growth and puberty
-
Noonan J.A. Noonan syndrome and related disorders: alterations in growth and puberty. Rev. Endoc. Metab. Disord. 2006, 7:251-255.
-
(2006)
Rev. Endoc. Metab. Disord.
, vol.7
, pp. 251-255
-
-
Noonan, J.A.1
-
34
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing Sonic Hedgehog
-
Oro A.E., Higgins K.M., Hu Z., Bonifas J.M., Epstein E.H., Scott M.P. Basal cell carcinomas in mice overexpressing Sonic Hedgehog. Science 1997, 276:817-821.
-
(1997)
Science
, vol.276
, pp. 817-821
-
-
Oro, A.E.1
Higgins, K.M.2
Hu, Z.3
Bonifas, J.M.4
Epstein, E.H.5
Scott, M.P.6
-
35
-
-
7744240345
-
Gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
-
Pan Y., Lin M.H., Tian X., Cheng H.T., Gridley T., Shen J., Kopan R. Gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev. Cell 2004, 7:731-743.
-
(2004)
Dev. Cell
, vol.7
, pp. 731-743
-
-
Pan, Y.1
Lin, M.H.2
Tian, X.3
Cheng, H.T.4
Gridley, T.5
Shen, J.6
Kopan, R.7
-
36
-
-
75149112680
-
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: from bedside to bench and back
-
Rauen K.A., Schoyer L., McCormick F., Lin A.E., Allanson J.E., Stevenson D.A., Gripp K.W., Neri G., Carey J.C., Legius E., Tartaglia M., Schubbert S., Roberts A.E., Gelb B.D., Shannon K., Gutmann D.H., McMahon M., Guerra C., Fagin J.A., Yu B., Aoki Y., Neel B.G., Balmain A., Drake R.R., Nolan G.P., Zenker M., Bollag G., Sebolt-Leopold J., Gibbs J.B., Silva A.J., Patton E.E., Viskochil D.H., Kieran M.W., Korf B.R., Hagerman R.J., Packer R.J., Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: from bedside to bench and back. Am. J. Med. Genet. A 2010, 152A:4-24.
-
(2010)
Am. J. Med. Genet. A
, vol.152 A
, pp. 4-24
-
-
Rauen, K.A.1
Schoyer, L.2
McCormick, F.3
Lin, A.E.4
Allanson, J.E.5
Stevenson, D.A.6
Gripp, K.W.7
Neri, G.8
Carey, J.C.9
Legius, E.10
Tartaglia, M.11
Schubbert, S.12
Roberts, A.E.13
Gelb, B.D.14
Shannon, K.15
Gutmann, D.H.16
McMahon, M.17
Guerra, C.18
Fagin, J.A.19
Yu, B.20
Aoki, Y.21
Neel, B.G.22
Balmain, A.23
Drake, R.R.24
Nolan, G.P.25
Zenker, M.26
Bollag, G.27
Sebolt-Leopold, J.28
Gibbs, J.B.29
Silva, A.J.30
Patton, E.E.31
Viskochil, D.H.32
Kieran, M.W.33
Korf, B.R.34
Hagerman, R.J.35
Packer, R.J.36
Melese, T.37
more..
-
37
-
-
27844547641
-
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle
-
e331-e331
-
Rendl M., Lewis L., Fuchs E. Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol. 2005, 3. e331-e331.
-
(2005)
PLoS Biol.
, vol.3
-
-
Rendl, M.1
Lewis, L.2
Fuchs, E.3
-
38
-
-
0034104590
-
The Ras branch of small GTPases: Ras family members don't fall far from the tree
-
Reuther G.W., Der C.J. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr. Opin. Cell Biol. 2000, 12:157-165.
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 157-165
-
-
Reuther, G.W.1
Der, C.J.2
-
39
-
-
33751257771
-
The cardiofaciocutaneous syndrome
-
Roberts A., Allanson J., Jadico S.K., Kavamura M.I., Noonan J., Opitz J.M., Young T., Neri G. The cardiofaciocutaneous syndrome. J. Med. Genet. 2006, 43:833-842.
-
(2006)
J. Med. Genet.
, vol.43
, pp. 833-842
-
-
Roberts, A.1
Allanson, J.2
Jadico, S.K.3
Kavamura, M.I.4
Noonan, J.5
Opitz, J.M.6
Young, T.7
Neri, G.8
-
40
-
-
33746434378
-
Cancer targets in the Ras pathway
-
Rodriguez-Viciana P., Tetsu O., Oda K., Okada J., Rauen K., McCormick F. Cancer targets in the Ras pathway. Cold Spring Harbor Symp. Quant. Biol. 2005, 70:461-467.
-
(2005)
Cold Spring Harbor Symp. Quant. Biol.
, vol.70
, pp. 461-467
-
-
Rodriguez-Viciana, P.1
Tetsu, O.2
Oda, K.3
Okada, J.4
Rauen, K.5
McCormick, F.6
-
41
-
-
33644696097
-
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome
-
Rodriguez-Viciana P., Tetsu O., Tidyman W.E., Estep A.L., Conger B.A., Cruz M.S., McCormick F., Rauen K.A. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science 2006, 311:1287-1290.
-
(2006)
Science
, vol.311
, pp. 1287-1290
-
-
Rodriguez-Viciana, P.1
Tetsu, O.2
Tidyman, W.E.3
Estep, A.L.4
Conger, B.A.5
Cruz, M.S.6
McCormick, F.7
Rauen, K.A.8
-
42
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodriguez-Viciana P., Warne P.H., Khwaja A., Marte B.M., Pappin D., Das P., Waterfield M.D., Ridley A., Downward J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 1997, 89:457-467.
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
Marte, B.M.4
Pappin, D.5
Das, P.6
Waterfield, M.D.7
Ridley, A.8
Downward, J.9
-
43
-
-
0029924287
-
Fibroblast growth factor signaling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle
-
Rosenquist T.A., Martin G.R. Fibroblast growth factor signaling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle. Dev. Dyn. 1996, 205:379-386.
-
(1996)
Dev. Dyn.
, vol.205
, pp. 379-386
-
-
Rosenquist, T.A.1
Martin, G.R.2
-
44
-
-
34248561776
-
Determination of hair structure and shape
-
Schlake T. Determination of hair structure and shape. Semin. Cell Dev. Biol. 2007, 18:267-273.
-
(2007)
Semin. Cell Dev. Biol.
, vol.18
, pp. 267-273
-
-
Schlake, T.1
-
46
-
-
33644622238
-
Germline KRAS mutations cause Noonan syndrome
-
Schubbert S., Zenker M., Rowe S.L., Boll S., Klein C., Bollag G., van der Burgt I., Musante L., Kalscheuer V., Wehner L.E., Nguyen H., West B., Zhang K.Y., Sistermans E., Rauch A., Niemeyer C.M., Shannon K., Kratz C.P. Germline KRAS mutations cause Noonan syndrome. Nat. Genet. 2006, 38:331-336.
-
(2006)
Nat. Genet.
, vol.38
, pp. 331-336
-
-
Schubbert, S.1
Zenker, M.2
Rowe, S.L.3
Boll, S.4
Klein, C.5
Bollag, G.6
van der Burgt, I.7
Musante, L.8
Kalscheuer, V.9
Wehner, L.E.10
Nguyen, H.11
West, B.12
Zhang, K.Y.13
Sistermans, E.14
Rauch, A.15
Niemeyer, C.M.16
Shannon, K.17
Kratz, C.P.18
-
47
-
-
0031005779
-
A thousand and one roles for the Drosophila EGF receptor
-
Schweitzer R., Shilo B.Z. A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 1997, 13:191-196.
-
(1997)
Trends Genet.
, vol.13
, pp. 191-196
-
-
Schweitzer, R.1
Shilo, B.Z.2
-
48
-
-
84857589094
-
Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development
-
Siegel D.H., Mann J.A., Krol A.L., Rauen K.A. Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development. Br. J. Dermatol. 2012, 166:601-607.
-
(2012)
Br. J. Dermatol.
, vol.166
, pp. 601-607
-
-
Siegel, D.H.1
Mann, J.A.2
Krol, A.L.3
Rauen, K.A.4
-
49
-
-
79952429680
-
Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome
-
Siegel D.H., McKenzie J., Frieden I.J., Rauen K.A. Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome. Br. J. Dermatol. 2011, 164:521-529.
-
(2011)
Br. J. Dermatol.
, vol.164
, pp. 521-529
-
-
Siegel, D.H.1
McKenzie, J.2
Frieden, I.J.3
Rauen, K.A.4
-
50
-
-
13144259688
-
Sonic Hedgehog signaling is essential for hair development
-
St-Jacques B., Dassule H.R., Karavanova I., Botchkarev V.A., Li J., Danielian P.S., McMahon J.A., Lewis P.M., Paus R., McMahon A.P. Sonic Hedgehog signaling is essential for hair development. Curr. Biol. 1998, 8:1058-1068.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1058-1068
-
-
St-Jacques, B.1
Dassule, H.R.2
Karavanova, I.3
Botchkarev, V.A.4
Li, J.5
Danielian, P.S.6
McMahon, J.A.7
Lewis, P.M.8
Paus, R.9
McMahon, A.P.10
-
51
-
-
0034103657
-
Conditional inactivation of Fgf4 reveals complexity of signaling during limb bud development
-
Sun X., Lewandoski M., Meyers E.N., Liu Y.H., Maxson R.E., Martin G.R. Conditional inactivation of Fgf4 reveals complexity of signaling during limb bud development. Nat. Genet. 2000, 25:83-86.
-
(2000)
Nat. Genet.
, vol.25
, pp. 83-86
-
-
Sun, X.1
Lewandoski, M.2
Meyers, E.N.3
Liu, Y.H.4
Maxson, R.E.5
Martin, G.R.6
-
53
-
-
0028178786
-
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
-
Tabata T., Kornberg T.B. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 1994, 76:89-102.
-
(1994)
Cell
, vol.76
, pp. 89-102
-
-
Tabata, T.1
Kornberg, T.B.2
-
54
-
-
68649121646
-
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
-
Tidyman W.E., Rauen K.A. The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr. Opin. Genet. Dev. 2009, 19:230-236.
-
(2009)
Curr. Opin. Genet. Dev.
, vol.19
, pp. 230-236
-
-
Tidyman, W.E.1
Rauen, K.A.2
-
55
-
-
11144356354
-
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
-
Tuveson D.A., Shaw A.T., Willis N.A., Silver D.P., Jackson E.L., Chang S., Mercer K.L., Grochow R., Hock H., Crowley D., Hingorani S.R., Zaks T., King C., Jacobetz M.A., Wang L., Bronson R.T., Orkin S.H., DePinho R.A., Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004, 5:375-387.
-
(2004)
Cancer Cell
, vol.5
, pp. 375-387
-
-
Tuveson, D.A.1
Shaw, A.T.2
Willis, N.A.3
Silver, D.P.4
Jackson, E.L.5
Chang, S.6
Mercer, K.L.7
Grochow, R.8
Hock, H.9
Crowley, D.10
Hingorani, S.R.11
Zaks, T.12
King, C.13
Jacobetz, M.A.14
Wang, L.15
Bronson, R.T.16
Orkin, S.H.17
DePinho, R.A.18
Jacks, T.19
-
56
-
-
27644470220
-
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning
-
Verheyden J.M., Lewandoski M., Deng C., Harfe B.D., Sun X. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 2005, 132:4235-4245.
-
(2005)
Development
, vol.132
, pp. 4235-4245
-
-
Verheyden, J.M.1
Lewandoski, M.2
Deng, C.3
Harfe, B.D.4
Sun, X.5
-
57
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 1994, 269:5241-5248.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
58
-
-
33644792126
-
Igf-I signaling controls the hair growth cycle and the differentiation of hair shafts
-
Weger N., Schlake T. Igf-I signaling controls the hair growth cycle and the differentiation of hair shafts. J. Invest. Dermatol. 2005, 125:873-882.
-
(2005)
J. Invest. Dermatol.
, vol.125
, pp. 873-882
-
-
Weger, N.1
Schlake, T.2
-
59
-
-
0031700905
-
FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
-
Weinstein M., Xu X., Ohyama K., Deng C.X. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 1998, 125:3615-3623.
-
(1998)
Development
, vol.125
, pp. 3615-3623
-
-
Weinstein, M.1
Xu, X.2
Ohyama, K.3
Deng, C.X.4
-
60
-
-
77949690425
-
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis
-
Yang J., Meyer M., Müller A.-K., Böhm F., Grose R., Dauwalder T., Verrey F., Kopf M., Partanen J., Bloch W., Ornitz D.M., Werner S. Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J. Cell. Biol. 2010, 188:935-952.
-
(2010)
J. Cell. Biol.
, vol.188
, pp. 935-952
-
-
Yang, J.1
Meyer, M.2
Müller, A.-K.3
Böhm, F.4
Grose, R.5
Dauwalder, T.6
Verrey, F.7
Kopf, M.8
Partanen, J.9
Bloch, W.10
Ornitz, D.M.11
Werner, S.12
-
61
-
-
0025976838
-
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
-
Yayon A., Klagsbrun M., Esko J.D., Leder P., Ornitz D.M. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991, 64:841-848.
-
(1991)
Cell
, vol.64
, pp. 841-848
-
-
Yayon, A.1
Klagsbrun, M.2
Esko, J.D.3
Leder, P.4
Ornitz, D.M.5
-
62
-
-
0035733108
-
The control of the false discovery rate in multiple testing under dependency
-
Yekutieli D., Benjamini Y. The control of the false discovery rate in multiple testing under dependency. Ann. Stat. 2001, 29:1165-1188.
-
(2001)
Ann. Stat.
, vol.29
, pp. 1165-1188
-
-
Yekutieli, D.1
Benjamini, Y.2
-
63
-
-
41649095548
-
FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis
-
Yu K., Ornitz D.M. FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development 2008, 135:483-491.
-
(2008)
Development
, vol.135
, pp. 483-491
-
-
Yu, K.1
Ornitz, D.M.2
-
64
-
-
0038782306
-
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
-
Yu K., Xu J., Liu Z., Sosic D., Shao J., Olson E.N., Towler D.A., Ornitz D.M. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 2003, 130:3063-3074.
-
(2003)
Development
, vol.130
, pp. 3063-3074
-
-
Yu, K.1
Xu, J.2
Liu, Z.3
Sosic, D.4
Shao, J.5
Olson, E.N.6
Towler, D.A.7
Ornitz, D.M.8
-
65
-
-
64549158874
-
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds
-
Zhang Z., Verheyden J.M., Hassell J.A., Sun X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev. Cell 2009, 16:607-613.
-
(2009)
Dev. Cell
, vol.16
, pp. 607-613
-
-
Zhang, Z.1
Verheyden, J.M.2
Hassell, J.A.3
Sun, X.4
-
66
-
-
33847248863
-
Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations
-
Zenker M., Lehmann K., Schulz A.L., Barth H., Hansmann D., Koenig R., Korinthenberg R., Kreiss-Nachtsheim M., Meinecke P., Morlot S., Mundlos S., Quante A.S., Raskin S., Schnabel D., Wehner L.E., Kratz C.P., Horn D., Kutsche K. Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. J. Med. Genet. 2007, 44:131-135.
-
(2007)
J. Med. Genet.
, vol.44
, pp. 131-135
-
-
Zenker, M.1
Lehmann, K.2
Schulz, A.L.3
Barth, H.4
Hansmann, D.5
Koenig, R.6
Korinthenberg, R.7
Kreiss-Nachtsheim, M.8
Meinecke, P.9
Morlot, S.10
Mundlos, S.11
Quante, A.S.12
Raskin, S.13
Schnabel, D.14
Wehner, L.E.15
Kratz, C.P.16
Horn, D.17
Kutsche, K.18
-
67
-
-
0028900073
-
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation
-
Zubiaga A.M., Belasco J.G., Greenberg M.E. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 1995, 15:2219-2230.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2219-2230
-
-
Zubiaga, A.M.1
Belasco, J.G.2
Greenberg, M.E.3
|