Airway Epithelial NF-κB Activation Promotes Mycoplasma pneumoniae Clearance in Mice

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Jiang, Di ^a   Nelson, Mark L ^a   Gally, Fabienne ^a   Smith, Sean ^a   Wu, Qun ^a   Minor, Maisha ^a   Case, Stephanie ^a   Thaikoottathil, Jyoti ^a   Chu, Hong Wei ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b ECHELON BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 TERT BUTYLDOXYCYCLINE; BINDING PROTEIN; DOXYCYCLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SHORT PALATE LUNG AND NASAL EPITHELIUM CLONE 1 PROTEIN; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; CELL CULTURE; CONTROLLED STUDY; EPITHELIUM CELL; IN VIVO STUDY; LUNG CLEARANCE; MOUSE; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; NONHUMAN; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; TRACHEA MUCOSA; TRANSGENE;

ANIMALS; CELLS, CULTURED; DOXYCYCLINE; HUMANS; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCOCILIARY CLEARANCE; MYCOPLASMA PNEUMONIAE; NF-KAPPA B; PNEUMONIA, MYCOPLASMA; RESPIRATORY MUCOSA;

BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS; MYCOPLASMA PNEUMONIAE;

EID: 84871692481     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052969     Document Type: Article

References (36)

1. Kraft M, Adler KB, Ingram JL, Crews AL, Atkinson TP, et al. (2008) Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma. Eur Respir J 31: 43-46.
2. Kraft M, Cassell GH, Henson JE, Watson H, Williamson J, et al. (1998) Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am J Respir Crit Care Med 158: 998-1001.
3. Esposito S, Droghetti R, Bosis S, Claut L, Marchisio P, et al. (2002) Cytokine secretion in children with acute Mycoplasma pneumoniae infection and wheeze. Pediatr Pulmonol 34: 122-127.
4. Hardy RD, Jafri HS, Olsen K, Hatfield J, Iglehart J, et al. (2002) Mycoplasma pneumoniae induces chronic respiratory infection, airway hyperreactivity, and pulmonary inflammation: a murine model of infection-associated chronic reactive airway disease. Infect Immun 70: 649-654.
5. Chu HW, Gally F, Thaikoottathil J, Janssen-Heininger YM, Wu Q, et al. (2010) SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling. Respir Res 11: 155.
6. Vieira RP, Toledo AC, Ferreira SC, Santos AB, Medeiros MC, et al. (2011) Airway epithelium mediates the anti-inflammatory effects of exercise on asthma. Respir Physiol Neurobiol 175: 383-389.
7. Poynter ME, Irvin CG, Janssen-Heininger YM, (2003) A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol 170: 6257-6265.
8. Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, et al. (2008) Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med 177: 959-969.
9. Sheller JR, Polosukhin VV, Mitchell D, Cheng DS, Peebles RS, et al. (2009) Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res 35: 883-895.
10. Chen SM, Cheng DS, Williams BJ, Sherrill TP, Han W, et al. (2008) The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol 153: 420-428.
11. Alkawash M, Head M, Alshami I, Soothill JS, (1999) The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains. J Antimicrob Chemother 44: 385-387.
12. Bebear CM, Renaudin H, Charron A, Gruson D, Lefrancois M, et al. (2000) In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob Agents Chemother 44: 2557-2560.
13. Cohen MA, Huband MD, Mailloux GB, Yoder SL, Roland GE, et al. (1991) In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis 14: 245-258.
14. Bouchillon SK, Hoban DJ, Johnson BM, Stevens TM, Dowzicky MJ, et al. (2005) In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002. Diagn Microbiol Infect Dis 51: 291-295.
15. Halterman MW, (2011) An improved method for the study of apoptosis-related genes using the tet-on system. J Biomol Screen 16: 332-337.
16. Zhu P, Aller MI, Baron U, Cambridge S, Bausen M, et al. (2007) Silencing and un-silencing of tetracycline-controlled genes in neurons. PLoS One 2: e533.
17. Gally F, Di YP, Smith SK, Minor MN, Liu Y, et al. (2011) SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol 178: 2159-2167.
18. Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, et al. (2007) Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol 179: 3995-4002.
19. Wu Q, Martin RJ, Lafasto S, Efaw BJ, Rino JG, et al. (2008) Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med 177: 720-729.
20. Ather JL, Hodgkins SR, Janssen-Heininger YM, Poynter ME, (2011) Airway epithelial NF-kappaB activation promotes allergic sensitization to an innocuous inhaled antigen. Am J Respir Cell Mol Biol 44: 631-638.
21. Poynter ME, Irvin CG, Janssen-Heininger YM, (2002) Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol 160: 1325-1334.
22. Poynter ME, Cloots R, van Woerkom T, Butnor KJ, Vacek P, et al. (2004) NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol 173: 7003-7009.
23. Perkins ND, (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62.
24. Thaikoottathil J, Chu HW, (2011) MAPK/AP-1 activation mediates TLR2 agonist-induced SPLUNC1 expression in human lung epithelial cells. Mol Immunol 49: 415-422.
25. Wu Q, Jiang D, Minor MN, Martin RJ, Chu HW (2011) In vivo function of airway epithelial TLR2 in host defense against bacterial infection. Am J Physiol Lung Cell Mol Physiol.
26. Wu Q, Martin RJ, Rino JG, Jeyaseelan S, Breed R, et al. (2007) A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice. Am J Physiol Lung Cell Mol Physiol 292: L1064-1072.
27. Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, et al. (2007) Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J Immunol 178: 6504-6513.
28. Bebear C, Cantet P, Renaudin H, Quentin C, (1985) Comparative activity of minocycline and doxycycline on mycoplasmas pathogenic for man. Pathol Biol (Paris) 33: 577-580.
29. Hannan PC, Woodnutt G, (2000) In vitro activity of gemifloxacin (SB 265805; LB20304a) against human mycoplasmas. J Antimicrob Chemother 45: 367-369.
30. Malinverni R, Kuo CC, Campbell LA, Lee A, Grayston JT, (1995) Effects of two antibiotic regimens on course and persistence of experimental Chlamydia pneumoniae TWAR pneumonitis. Antimicrob Agents Chemother 39: 45-49.
31. Prall AK, Longo GM, Mayhan WG, Waltke EA, Fleckten B, et al. (2002) Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice. J Vasc Surg 35: 923-929.
32. Heine HS, Bassett J, Miller L, Hartings JM, Ivins BE, et al. (2007) Determination of antibiotic efficacy against Bacillus anthracis in a mouse aerosol challenge model. Antimicrob Agents Chemother 51: 1373-1379.
33. Alvarez JI, Krishnamurthy J, Teale JM, (2009) Doxycycline treatment decreases morbidity and mortality of murine neurocysticercosis: evidence for reduction of apoptosis and matrix metalloproteinase activity. Am J Pathol 175: 685-695.
34. Chu HW, Honour JM, Rawlinson CA, Harbeck RJ, Martin RJ, (2003) Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice. Infect Immun 71: 1520-1526.
35. Chu HW, Halliday JL, Martin RJ, Leung DY, Szefler SJ, et al. (1998) Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med 158: 1936-1944.
36. Gally F, Minor MN, Smith SK, Case SR, Chu HW (2011) Heat Shock Factor 1 Protects against Lung Mycoplasma pneumoniae Infection in Mice. J Innate Immun.