SPLUNC1 regulation in airway epithelial cells: Role of toll-like receptor 2 signaling

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Chu, Hong Wei ^a   Gally, Fabienne ^a   Thaikoottathil, Jyoti ^a   Janssen Heininger, Yvonne M ^b   Wu, Qun ^a   Zhang, Gongyi ^a   Reisdorph, Nichole ^a   Case, Stephanie ^a   Minor, Maisha ^a   Smith, Sean ^a   Jiang, Di ^a   Michels, Nicole ^a   Simon, Glenn ^a   Martin, Richard J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; PROTEIN; PROTEIN SPLUNC1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; GLYCOPROTEIN; PHOSPHOPROTEIN; PLUNC PROTEIN, HUMAN; PLUNC PROTEIN, MOUSE; TLR2 PROTEIN, HUMAN; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; EPITHELIUM CELL; GENE CONTROL; HUMAN; HUMAN CELL; MOUSE; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RNA INTERFERENCE; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; METABOLISM; RESPIRATORY TRACT MUCOSA;

ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; MICE; PHOSPHOPROTEINS; PNEUMONIA, MYCOPLASMA; RESPIRATORY MUCOSA; TOLL-LIKE RECEPTOR 2;

EID: 78049394190     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-155     Document Type: Article

References (41)

1. Weston WM, LeClair EE, Trzyna W, McHugh KM, Nugent P, Lafferty CM, Ma L, Tuan RS, Greene RM. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem 1999, 274:13698-13703. 10.1074/jbc.274.19.13698, 10224143.
2. Bingle CD, Bingle L. Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. Biochim Biophys Acta 2000, 1493:363-367.
3. LeClair EE. Four reasons to consider a novel class of innate immune molecules in the oral epithelium. J Dent Res 2003, 82:944-950. 10.1177/154405910308201202, 14630892.
4. Bingle CD, Gorr SU. Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family. Int J Biochem Cell Biol 2004, 36:2144-2152. 10.1016/j.biocel.2004.05.002, 15313462.
5. Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL. Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol 2004, 30:184-192. 10.1165/rcmb.2003-0142OC, 12920053.
6. Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem 2003, 278:1165-1173. 10.1074/jbc.M210523200, 12409287.
7. Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, Refaeli Y, Bowler R, Wenzel SE, Chen Z, et al. Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol 2007, 179:3995-4002.
8. Martin RJ, Kraft M, Chu HW, Berns EA, Cassell GH. A link between chronic asthma and chronic infection. J Allergy Clin Immunol 2001, 107:595-601. 10.1067/mai.2001.114242, 11295645.
9. Zhou HD, Li XL, Li GY, Zhou M, Liu HY, Yang YX, Deng T, Ma J, Sheng SR. Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus. Mol Cell Biochem 2008, 309:191-197. 10.1007/s11010-007-9659-3, 18049866.
10. Bartlett JA, Hicks BJ, Schlomann JM, Ramachandran S, Nauseef WM, McCray PB. PLUNC is a secreted product of neutrophil granules. J Leukoc Biol 2008, 83:1201-1206. 10.1189/jlb.0507302, 18245229.
11. Sung YK, Moon C, Yoo JY, Pearse D, Pevsner J, Ronnett GV. Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J Biol Chem 2002, 277:12762-12769. 10.1074/jbc.M106208200, 11821380.
12. Bingle L, Cross SS, High AS, Wallace WA, Devine DA, Havard S, Campos MA, Bingle CD. SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype. J Pathol 2005, 205:491-497. 10.1002/path.1726, 15685591.
13. Ghafouri B, Irander K, Lindbom J, Tagesson C, Lindahl M. Comparative proteomics of nasal fluid in seasonal allergic rhinitis. J Proteome Res 2006, 5:330-338. 10.1021/pr050341h, 16457599.
14. Boon K, Bailey NW, Yang J, Steel MP, Groshong S, Kervitsky D, Brown KK, Schwarz MI, Schwartz DA. Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF). PLoS One 2009, 4:e5134. 10.1371/journal.pone.0005134, 2661376, 19347046.
15. Yeh TH, Lee SY, Hsu WC. Expression of SPLUNC1 protein in nasal polyp epithelial cells in air-liquid interface culture treated with IL-13. Am J Rhinol Allergy 24:17-20. 10.2500/ajra.2010.24.3381, 20109312.
16. Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA, Bingle CD. Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis. Respir Res 2007, 8:79. 10.1186/1465-9921-8-79, 2203987, 17988392.
17. Chu HW, Jeyaseelan S, Rino JG, Voelker DR, Wexler RB, Campbell K, Harbeck RJ, Martin RJ. TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression. J Immunol 2005, 174:5713-5719.
18. Kielian T, Esen N, Bearden ED. Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia 2005, 49:567-576. 10.1002/glia.20144, 2394509, 15593098.
19. Uronen-Hansson H, Allen J, Osman M, Squires G, Klein N, Callard RE. Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 2004, 111:173-178. 10.1111/j.0019-2805.2003.01803.x, 1782406, 15027902.
20. Ingalls RR, Lien E, Golenbock DT. Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis. J Endotoxin Res 2000, 6:411-415.
21. Dziarski R, Gupta D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J Endotoxin Res 2000, 6:401-405.
22. Michelsen KS, Aicher A, Mohaupt M, Hartung T, Dimmeler S, Kirschning CJ, Schumann RR. The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J Biol Chem 2001, 276:25680-25686. 10.1074/jbc.M011615200, 11316801.
23. Dziarski R, Wang Q, Miyake K, Kirschning CJ, Gupta D. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components. J Immunol 2001, 166:1938-1944.
24. Chu HW, Balzar S, Seedorf GJ, Westcott JY, Trudeau JB, Silkoff P, Wenzel SE. Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma. Am J Pathol 2004, 165:1097-1106. 1618635, 15466377.
25. Trudeau J, Hu H, Chibana K, Chu HW, Westcott JY, Wenzel SE. Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13. J Allergy Clin Immunol 2006, 117:1446-1454. 10.1016/j.jaci.2006.01.049, 16751012.
26. Wu Q, Martin RJ, Rino JG, Jeyaseelan S, Breed R, Chu HW. A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice. Am J Physiol Lung Cell Mol Physiol 2007, 292:L1064-1072. 10.1152/ajplung.00301.2006, 17194718.
27. Refaeli Y, Field KA, Turner BC, Trumpp A, Bishop JM. The protooncogene MYC can break B cell tolerance. Proc Natl Acad Sci USA 2005, 102:4097-4102. 10.1073/pnas.0409832102, 552974, 15753301.
28. Chu HW, Campbell JA, Rino JG, Harbeck RJ, Martin RJ. Inhaled fluticasone propionate reduces concentration of Mycoplasma pneumoniae, inflammation, and bronchial hyperresponsiveness in lungs of mice. J Infect Dis 2004, 189:1119-1127. 10.1086/382050, 14999617.
29. Pei G, Baker K, Emfinger SM, Fowlkes DM, Lentz BR. Expression, isolation, and characterization of an active site (serine 528----alanine) mutant of recombinant bovine prothrombin. J Biol Chem 1991, 266:9598-9604.
30. Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem 1998, 273:33508-33516. 10.1074/jbc.273.50.33508, 9837931.
31. Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, et al. Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med 2008, 177:959-969. 10.1164/rccm.200707-1096OC, 2361423, 18263801.
32. Sugahara K, Iyama K, Sano K, Kuroki Y, Akino T, Matsumoto M. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Lab Invest 1996, 74:209-220.
33. Soerensen CM, Holmskov U, Aalbaek B, Boye M, Heegaard PM, Nielsen OL. Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue. Immunology 2005, 115:526-535. 10.1111/j.1365-2567.2005.02189.x, 1782188, 16011521.
34. Henning LN, Azad AK, Parsa KV, Crowther JE, Tridandapani S, Schlesinger LS. Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol 2008, 180:7847-7858. 2562757, 18523248.
35. Wu Q, Martin RJ, Lafasto S, Efaw BJ, Rino JG, Harbeck RJ, Chu HW. Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med 2008, 177:720-729. 10.1164/rccm.200709-1387OC, 18202345.
36. Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R. SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci USA 2009, 106:11412-11417. 10.1073/pnas.0903609106, 2708735, 19541605.
37. Murphy TF, Brauer AL, Grant BJ, Sethi S. Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am J Respir Crit Care Med 2005, 172:195-199. 10.1164/rccm.200412-1747OC, 2718466, 15805178.
38. Murphy TF, Parameswaran GI. Moraxella catarrhalis, a human respiratory tract pathogen. Clin Infect Dis 2009, 49:124-131. 10.1086/599375, 19480579.
39. Shen H, Yoshida H, Yan F, Li W, Xu F, Huang H, Jono H, Li JD. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. Biochem Biophys Res Commun 2008, 365:795-800. 10.1016/j.bbrc.2007.11.060, 18037371.
40. Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, Dietel S, Hippenstiel S, Singer BB, Bachmann S, Suttorp N, et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response. Cell Microbiol 2007, 9:694-707. 10.1111/j.1462-5822.2006.00821.x, 17054439.
41. Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, et al. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One 2009, 4:e5043. 10.1371/journal.pone.0005043, 2664466, 19357784.