메뉴 건너뛰기




Volumn 175, Issue 2, 2009, Pages 685-695

Doxycycline treatment decreases morbidity and mortality of murine neurocysticercosis: Evidence for reduction of apoptosis and matrix metalloproteinase activity

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 16; NEUTROPHIL COLLAGENASE; STROMELYSIN;

EID: 68449096480     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.081073     Document Type: Article
Times cited : (16)

References (55)
  • 2
    • 24944554903 scopus 로고    scopus 로고
    • Neurocysticercosis: Updated concepts about an old disease
    • Garcia HH, Del Brutto OH: Neurocysticercosis: updated concepts about an old disease. Lancet Neurol 2005, 4:653-661
    • (2005) Lancet Neurol , vol.4 , pp. 653-661
    • Garcia, H.H.1    Del Brutto, O.H.2
  • 4
    • 0034051778 scopus 로고    scopus 로고
    • Neurocysticercosis: Updates on epidemiology, pathogenesis, diagnosis, and management
    • White AC, Jr: Neurocysticercosis: updates on epidemiology, pathogenesis, diagnosis, and management. Annu Rev Med 2000, 51:187-206
    • (2000) Annu Rev Med , vol.51 , pp. 187-206
    • White Jr, A.C.1
  • 7
    • 0021703549 scopus 로고
    • Recent advances in the diagnosis and treatment of cerebral cysticercosis
    • Nash TE, Neva FA: Recent advances in the diagnosis and treatment of cerebral cysticercosis. N Engl J Med 1984, 311:1492-1496
    • (1984) N Engl J Med , vol.311 , pp. 1492-1496
    • Nash, T.E.1    Neva, F.A.2
  • 8
    • 1842413644 scopus 로고    scopus 로고
    • Taenia solium cysticercosis: Host-parasite interactions and the immune response
    • White AC, Jr., Robinson P, Kuhn R: Taenia solium cysticercosis: host-parasite interactions and the immune response. Chem Immunol 1997, 66:209-230
    • (1997) Chem Immunol , vol.66 , pp. 209-230
    • White Jr., A.C.1    Robinson, P.2    Kuhn, R.3
  • 9
    • 0036900278 scopus 로고    scopus 로고
    • Neurocysticercosis: An update
    • Carpio A: Neurocysticercosis: an update. Lancet Infect Dis 2002, 2:751-762
    • (2002) Lancet Infect Dis , vol.2 , pp. 751-762
    • Carpio, A.1
  • 10
    • 18144449665 scopus 로고    scopus 로고
    • Analysis of immune lesions in neurocysticercosis patients: Central nervous system response to helminth appears Th1-like instead of Th2
    • Restrepo BI, Llaguno P, Sandoval MA, Enciso JA, Teale JM: Analysis of immune lesions in neurocysticercosis patients: central nervous system response to helminth appears Th1-like instead of Th2. J Neuroimmunol 1998, 89:64-72
    • (1998) J Neuroimmunol , vol.89 , pp. 64-72
    • Restrepo, B.I.1    Llaguno, P.2    Sandoval, M.A.3    Enciso, J.A.4    Teale, J.M.5
  • 12
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff RM, Kivisakk P, Kidd G: Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol 2003, 3:569-581
    • (2003) Nat Rev Immunol , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 13
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms
    • Engelhardt B, Ransohoff RM: The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 2005, 26:485-495
    • (2005) Trends Immunol , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 14
    • 33644939049 scopus 로고    scopus 로고
    • Breakdown of the blood brain barrier and blood-cerebrospinal fluid barrier is associated with differential leukocyte migration in distinct compartments of the CNS during the course of murine NCC
    • Alvarez JI, Teale JM: Breakdown of the blood brain barrier and blood-cerebrospinal fluid barrier is associated with differential leukocyte migration in distinct compartments of the CNS during the course of murine NCC. J Neuroimmunol 2006, 173:45-55
    • (2006) J Neuroimmunol , vol.173 , pp. 45-55
    • Alvarez, J.I.1    Teale, J.M.2
  • 15
    • 44249103203 scopus 로고    scopus 로고
    • Multiple expression of matrix metalloproteinases in murine neurocysticercosis: Implications for leukocyte migration through multiple central nervous system barriers
    • Alvarez JI, Teale JM: Multiple expression of matrix metalloproteinases in murine neurocysticercosis: implications for leukocyte migration through multiple central nervous system barriers. Brain Research 2008, 1214:145-158
    • (2008) Brain Research , vol.1214 , pp. 145-158
    • Alvarez, J.I.1    Teale, J.M.2
  • 16
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: Biological actions and therapeutic opportunities
    • Baker AH, Edwards DR, Murphy G: Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002, 115:3719-3727
    • (2002) J Cell Sci , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 17
    • 0034176764 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Multifunctional contributors to tumor progression
    • McCawley LJ, Matrisian LM: Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 2000, 6:149-156
    • (2000) Mol Med Today , vol.6 , pp. 149-156
    • McCawley, L.J.1    Matrisian, L.M.2
  • 18
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • Sternlicht MD, Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001, 17:463-516
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 20
    • 34548515468 scopus 로고    scopus 로고
    • Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature
    • Alvarez JI, Teale JM: Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature. Brain Res 2007, 1169:98-111
    • (2007) Brain Res , vol.1169 , pp. 98-111
    • Alvarez, J.I.1    Teale, J.M.2
  • 21
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S, Anderson P, Durbeej M, van Rooijen N, Ivars F, Opdenakker G, Sorokin LM: Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med 2006, 203:1007-1019
    • (2006) J Exp Med , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6    Sorokin, L.M.7
  • 22
    • 34347271663 scopus 로고    scopus 로고
    • Differential changes in junctional complex proteins suggest the ependymal lining as the main source of leukocyte infiltration into ventricles in murine neurocysticercosis
    • Alvarez JI, Teale JM: Differential changes in junctional complex proteins suggest the ependymal lining as the main source of leukocyte infiltration into ventricles in murine neurocysticercosis. J Neuroimmunol 2007, 187:102-113
    • (2007) J Neuroimmunol , vol.187 , pp. 102-113
    • Alvarez, J.I.1    Teale, J.M.2
  • 23
    • 0029041446 scopus 로고
    • T cell gelatinases mediate basement membrane transmigration in vitro
    • Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL: T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol 1995, 154:4379-4389
    • (1995) J Immunol , vol.154 , pp. 4379-4389
    • Leppert, D.1    Waubant, E.2    Galardy, R.3    Bunnett, N.W.4    Hauser, S.L.5
  • 24
    • 34547793659 scopus 로고    scopus 로고
    • Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    • Rosenberg GA, Yang Y: Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus 2007, 22:E4
    • (2007) Neurosurg Focus , vol.22
    • Rosenberg, G.A.1    Yang, Y.2
  • 28
    • 0021861248 scopus 로고
    • Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis
    • Yim CW, Flynn NM, Fitzgerald FT: Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis. Antimicrob Agents Chemother 1985, 28:347-348
    • (1985) Antimicrob Agents Chemother , vol.28 , pp. 347-348
    • Yim, C.W.1    Flynn, N.M.2    Fitzgerald, F.T.3
  • 29
    • 33847206486 scopus 로고    scopus 로고
    • Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia
    • Burggraf D, Trinkl A, Dichgans M, Hamann GF: Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol Dis 2007, 25:506-513
    • (2007) Neurobiol Dis , vol.25 , pp. 506-513
    • Burggraf, D.1    Trinkl, A.2    Dichgans, M.3    Hamann, G.F.4
  • 30
    • 0033555819 scopus 로고    scopus 로고
    • Development of an animal model for neurocysticercosis: Immune response in the central nervous system is characterized by a predominance of gamma delta T cells
    • Cardona AE, Restrepo BI, Jaramillo JM, Teale JM: Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells. J Immunol 1999, 162:995-1002
    • (1999) J Immunol , vol.162 , pp. 995-1002
    • Cardona, A.E.1    Restrepo, B.I.2    Jaramillo, J.M.3    Teale, J.M.4
  • 31
    • 33646551934 scopus 로고    scopus 로고
    • Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation
    • Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL: Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab 2006, 26:1157-1164
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1157-1164
    • Lee, C.Z.1    Yao, J.S.2    Huang, Y.3    Zhai, W.4    Liu, W.5    Guglielmo, B.J.6    Lin, E.7    Yang, G.Y.8    Young, W.L.9
  • 33
    • 0035872463 scopus 로고    scopus 로고
    • Roles of the metallothionein family of proteins in the central nervous system
    • Hidalgo J, Aschner M, Zatta P, Vasak M: Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 2001, 55:133-145
    • (2001) Brain Res Bull , vol.55 , pp. 133-145
    • Hidalgo, J.1    Aschner, M.2    Zatta, P.3    Vasak, M.4
  • 34
    • 33746263669 scopus 로고    scopus 로고
    • Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice
    • Wiese L, Kurtzhals JA, Penkowa M: Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice. Exp Neurol 2006, 200:216-226
    • (2006) Exp Neurol , vol.200 , pp. 216-226
    • Wiese, L.1    Kurtzhals, J.A.2    Penkowa, M.3
  • 35
    • 33646268801 scopus 로고    scopus 로고
    • Metallothioneins are multipurpose neuroprotectants during brain pathology
    • Penkowa M: Metallothioneins are multipurpose neuroprotectants during brain pathology. Febs J 2006, 273:1857-1870
    • (2006) Febs J , vol.273 , pp. 1857-1870
    • Penkowa, M.1
  • 36
    • 0027373064 scopus 로고
    • Bacterial collagenase disrupts extracellular matrix and opens blood-brain barrier in rat
    • Rosenberg GA, Estrada E, Kelley RO, Kornfeld M: Bacterial collagenase disrupts extracellular matrix and opens blood-brain barrier in rat. Neurosci Lett 1993, 160:117-119
    • (1993) Neurosci Lett , vol.160 , pp. 117-119
    • Rosenberg, G.A.1    Estrada, E.2    Kelley, R.O.3    Kornfeld, M.4
  • 37
    • 0033576645 scopus 로고    scopus 로고
    • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
    • Powell WC, Fingleton B, Wilson CL, Boothby M, Matrisian LM: The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol 1999, 9:1441-1447
    • (1999) Curr Biol , vol.9 , pp. 1441-1447
    • Powell, W.C.1    Fingleton, B.2    Wilson, C.L.3    Boothby, M.4    Matrisian, L.M.5
  • 38
    • 20944432778 scopus 로고    scopus 로고
    • Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice
    • Davies JE, Wang L, Garcia-Oroz L, Cook LJ, Vacher C, O'Donovan DG, Rubinsztein DC: Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat Med 2005, 11:672-677
    • (2005) Nat Med , vol.11 , pp. 672-677
    • Davies, J.E.1    Wang, L.2    Garcia-Oroz, L.3    Cook, L.J.4    Vacher, C.5    O'Donovan, D.G.6    Rubinsztein, D.C.7
  • 40
    • 0035094532 scopus 로고    scopus 로고
    • Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis
    • Gary DS, Mattson MP: Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J Neurochem 2001, 76:1485-1496
    • (2001) J Neurochem , vol.76 , pp. 1485-1496
    • Gary, D.S.1    Mattson, M.P.2
  • 41
    • 21844450866 scopus 로고    scopus 로고
    • A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia
    • Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA: A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci 2005, 25:6401-6408
    • (2005) J Neurosci , vol.25 , pp. 6401-6408
    • Gu, Z.1    Cui, J.2    Brown, S.3    Fridman, R.4    Mobashery, S.5    Strongin, A.Y.6    Lipton, S.A.7
  • 42
    • 0142139346 scopus 로고    scopus 로고
    • Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia
    • Sugawara T, Chan PH: Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 2003, 5:597-607
    • (2003) Antioxid Redox Signal , vol.5 , pp. 597-607
    • Sugawara, T.1    Chan, P.H.2
  • 43
    • 0032756355 scopus 로고    scopus 로고
    • The antioxidant function of metallothionein in the heart
    • Kang YJ: The antioxidant function of metallothionein in the heart. Proc Soc Exp Biol Med 1999, 222:263-273
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 263-273
    • Kang, Y.J.1
  • 45
    • 0034069770 scopus 로고    scopus 로고
    • Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-alpha
    • Carrasco J, Giralt M, Penkowa M, Stalder AK, Campbell IL, Hidalgo J: Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-alpha. Exp Neurol 2000, 163:46-54
    • (2000) Exp Neurol , vol.163 , pp. 46-54
    • Carrasco, J.1    Giralt, M.2    Penkowa, M.3    Stalder, A.K.4    Campbell, I.L.5    Hidalgo, J.6
  • 46
    • 0033119327 scopus 로고    scopus 로고
    • CNS wound healing is severely depressed in metallothionein I- and II-deficient mice
    • Penkowa M, Carrasco J, Giralt M, Moos T, Hidalgo J: CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J Neurosci 1999, 19:2535-2545
    • (1999) J Neurosci , vol.19 , pp. 2535-2545
    • Penkowa, M.1    Carrasco, J.2    Giralt, M.3    Moos, T.4    Hidalgo, J.5
  • 47
    • 0030828933 scopus 로고    scopus 로고
    • Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse
    • Vela JM, Hidalgo J, Gonzalez B, Castellano B: Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse. Brain Res 1997, 767:345-355
    • (1997) Brain Res , vol.767 , pp. 345-355
    • Vela, J.M.1    Hidalgo, J.2    Gonzalez, B.3    Castellano, B.4
  • 50
    • 0028255910 scopus 로고
    • Extracellular matrix-degrading proteinases in the nervous system
    • Romanic AM, Madri JA: Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol 1994, 4:145-156
    • (1994) Brain Pathol , vol.4 , pp. 145-156
    • Romanic, A.M.1    Madri, J.A.2
  • 51
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • Yong VW, Power C, Forsyth P, Edwards DR: Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2001, 2:502-511
    • (2001) Nat Rev Neurosci , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 52
    • 0032200444 scopus 로고    scopus 로고
    • Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
    • Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T: Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 1998, 12:12-26
    • (1998) Adv Dent Res , vol.12 , pp. 12-26
    • Golub, L.M.1    Lee, H.M.2    Ryan, M.E.3    Giannobile, W.V.4    Payne, J.5    Sorsa, T.6
  • 53
    • 1842527873 scopus 로고    scopus 로고
    • Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial
    • Brown DL, Desai KK, Vakili BA, Nouneh C, Lee HM, Golub LM: Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial. Arterioscler Thromb Vasc Biol 2004, 24:733-738
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 733-738
    • Brown, D.L.1    Desai, K.K.2    Vakili, B.A.3    Nouneh, C.4    Lee, H.M.5    Golub, L.M.6
  • 54
    • 0036518135 scopus 로고    scopus 로고
    • Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline
    • Roach DM, Fitridge RA, Laws PE, Millard SH, Varelias A, Cowled PA: Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline. Eur J Vasc Endovasc Surg 2002, 23:260-269
    • (2002) Eur J Vasc Endovasc Surg , vol.23 , pp. 260-269
    • Roach, D.M.1    Fitridge, R.A.2    Laws, P.E.3    Millard, S.H.4    Varelias, A.5    Cowled, P.A.6
  • 55
    • 0027502990 scopus 로고
    • Doxycycline and pyrimethamine for toxoplasmic encephalitis
    • Hagberg L, Palmertz B, Lindberg J: Doxycycline and pyrimethamine for toxoplasmic encephalitis. Scand J Infect Dis 1993, 25:157-160
    • (1993) Scand J Infect Dis , vol.25 , pp. 157-160
    • Hagberg, L.1    Palmertz, B.2    Lindberg, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.