SAMHD1 deprives HIV of nucleotides, essential for viral DNA synthesis;SAMHD1 prive le VIH des nucléotides essentiels à la synthèse d'ADN viral

Medecine/Sciences

Volumn 28, Issue 11, 2012, Pages 909-910

  Lahouassa, Hichem ^a   Dragin, Loïc ^a   Transy, Catherine ^a   Margottin Goguet, Florence ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; RNA DIRECTED DNA POLYMERASE; SAMHD1 PROTEIN, HUMAN; VIRUS PROTEIN; VPX PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 2; VPX PROTEIN, SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMAL; ARTICLE; DENDRITIC CELL; DNA REPLICATION; GENETICS; HAPLORHINI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; METABOLISM; NERVOUS SYSTEM MALFORMATION; NEUROLOGIC DISEASE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; VIROLOGY; VIRUS REPLICATION;

ANIMALS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; DENDRITIC CELLS; DEOXYGUANINE NUCLEOTIDES; DEOXYRIBONUCLEOTIDES; DNA REPLICATION; HAPLORHINI; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-2; HUMANS; MACROPHAGES; MONOMERIC GTP-BINDING PROTEINS; NERVOUS SYSTEM MALFORMATIONS; PROTEIN STRUCTURE, TERTIARY; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

EID: 84871668396     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/20122811002     Document Type: Article

References (10)

1. Hrecka K, Hao C, Gierszewska M, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 2011;474:658-61.
2. Laguette N, Sobhian B, Casartelli N, et al. SAMHD1 is the dendritic-and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011;474:654-7.
3. Lahouassa H, Daddacha W, Hofmann H, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 2012;13:223-8.
4. Ayinde D, Maudet C, Transy C, Margottin-Goguet F. Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr? Retrovirology 2010;7:35.
5. Goujon C, Riviere L, Jarrosson-Wuilleme L, et al. SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology 2007;4:2.
6. Diamond TL, Roshal M, Jamburuthugoda VK, et al. Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem 2004;279:51545-53. (Pubitemid 40017904)
7. Rice GI, Bond J, Asipu A, et al. Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet 2009;41:829-32.
8. Goldstone DC, Ennis-Adeniran V, Hedden JJ, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 2011;480:379-82.
9. Powell RD, Holland PJ, Hollis T, Perrino FW. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem 2011;286:43596-600.
10. Marquet R, Guerrero S, Bernacchi S. Un facteur de transcription se fait complice du VIH-1 pour détruire les défenses cellulaires. Med Sci (Paris) 2012;28:356-8.