Influence of human lactoferrin expression on iron homeostasis, flavonoids, and antioxidants in transgenic tobacco

Molecular Biotechnology

Volumn 53, Issue 2, 2013, Pages 118-128

  Kumar, Vinay ^a   Gill, Tejpal ^a   Grover, Sunita ^b   Ahuja, Paramvir Singh ^a   Yadav, Sudesh Kumar ^a  

^a CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

^b NATIONAL DAIRY RESEARCH INSTITUTE   (India)

Author keywords

Antioxidants; Human lactoferrin; Iron homeostasis; Total flavonoids

Indexed keywords

ANTIOXIDANT ENZYME; ANTIOXIDANTS; ASCORBATE PEROXIDASE; BIOSYNTHESIS PATHWAYS; CAMV 35S PROMOTER; CHLOROPHYLL CONTENTS; DOWN-REGULATION; GENES ENCODING; GLUTATHIONE REDUCTASE; GLUTATHIONE-S-TRANSFERASE; HUMAN LACTOFERRIN; IRON CONTENT; IRON DEFICIENCY; IRON HOMEOSTASIS; IRON TRANSPORTER; METAL TRANSPORTERS; PHENYLALANINE AMMONIA-LYASE; PROANTHOCYANIDINS; TOTAL PHENOLICS; TRANSGENIC TOBACCO;

AMINO ACIDS; BODY FLUIDS; CHLOROPHYLL; ENCODING (SYMBOLS); ENZYMES; FLAVONOIDS; GENE EXPRESSION; IRON; PEPTIDES; PHENOLS; PHYSIOLOGY; TOBACCO;

GENE EXPRESSION REGULATION;

ANTIOXIDANT; ASCORBATE PEROXIDASE; CATALASE; CHLOROPHYLL; COMPLEMENTARY DNA; DIHYDROFLAVONOL REDUCTASE; DOWNR EGULATION; FERRITIN; FERRITIN 1; FERRITIN 2; FLAVONOID; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; IRON; KANAMYCIN KINASE; LACTOFERRIN; OXIDOREDUCTASE; PHENYLALANINE AMMONIA LYASE; PROANTHOCYANIDIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOSYNTHESIS; CHLOROPHYLL CONTENT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; IRON STORAGE; LOBELIA; NONHUMAN; PROMOTER REGION; SHOOT; TOBACCO; TRANSGENIC PLANT; TRANSGENIC TOBACCO; WILD PLANT;

ANTIOXIDANTS; BIOTECHNOLOGY; CHLOROPHYLL; CLONING, MOLECULAR; FLAVONOIDS; GENE EXPRESSION REGULATION, PLANT; HOMEOSTASIS; HUMANS; IRON; LACTOFERRIN; METABOLIC NETWORKS AND PATHWAYS; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; TOBACCO;

NICOTIANA TABACUM;

EID: 84871663270     PISSN: 10736085     EISSN: 15590305     Source Type: Journal    
DOI: 10.1007/s12033-012-9495-x     Document Type: Article

References (43)

1. Adlerova, L.; Bartoskova, A.; Faldyna, M. (2008). Lactoferrin: A review. Vaterinarni Medicina, 53, 457-468.
2. Stefanova, G.; Vlahova, M.; Atanassov, A. (2008). Production of recombinant human lactoferrin from transgenic plants. Biologia Plantarum, 52, 423-428.
3. Choi, S. M.; Lee, O. S.; Kwon, S. K.; Kwak, S. S.; Yu, D. Y.; Lee, H. S. (2003). High expression of a human lactoferrin in transgenic tobacco cell cultures. Biotechnology Letters, 25, 213-218. (Pubitemid 36325797)
4. Gomez-Galera, S.; Rojas, E.; Sudhkar, D.; Zhu, C.; Pelacho, A. M.; Capell, T.; et al. (2010). Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Research, 19, 165-180.
5. Min, S. R.; Woo, J. W.; Jeong, W. J.; Han, S. K.; Lee, Y. B.; Liu, J. R. (2006). Production of human lactoferrin in transgenic cell suspension cultures of sweet potato. Biologia Plantarum, 50, 131-134. (Pubitemid 41738197)
6. Conesa, C.; Calvo, M.; Sanchez, L. (2010). Recombinant human lactoferrin: A valuable protein for pharmaceutical products and functional foods. Biotechnology Advances, 28, 831-838.
7. Takase, K.; Hagiwara, K.; Onodera, H.; Nishizawa, Y.; Ugaki, M.; Omura, T.; et al. (2005). Constitutive expression of human lactoferrin and its N-lobe in rice plants to confer disease resistance. Biochemistry and Cell Biology, 83, 239-249. (Pubitemid 41113550)
8. Yu, T.; Guo, C.; Wang, J.; Hao, P.; Sui, S.; Chen, X.; et al. (2011). Comprehensive characterization of the site specific N-glycosylation of wild type and recombinant human lactoferrin expressed in the milk of transgenic cloned cattle. Glycobiology, 21, 206-224.
9. Kamenarova, K.; Gecheff, K.; Stoyanova, M.; Muhovski, Y.; Anzai, H.; Atanassov, A. (2007). Production of recombinant human lactoferrin in transgenic barley. Biotechnology and Biotechnology Equipment, 21, 18-27. (Pubitemid 46374317)
10. Douchkov, D.; Gryczka, C.; Stephan, U. W.; Hell, R.; Baumlein, H. (2005). Ectopic expression of nicotianamine synthase genes results in improved iron accumulation and increased nickel tolerance in transgenic tobacco. Plant Cell and Environment, 38, 365-374. (Pubitemid 40307456)
11. Vert, G.; Grotz, N.; Dédaldéchamp, F.; Gaymard, F.; Guerinot, M. L.; Briat, J. F.; et al. (2002). IRT1, an Arabidopsis transporter essential for iron uptake from the soil and plant growth. The Plant Cell, 14, 1223-1233. (Pubitemid 34780429)
12. Huynh, C.; Andrews, N. W. (2008). Iron acquisition within host cells and the pathogenicity of Leishmania. Cellular Microbiology, 10, 293-300.
13. Wu, H.; Li, L.; Du, J.; Yuan, Y.; Cheng, X.; Ling, H. Q. (2005). Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana. Plant Cell Physiology, 46, 1505-1514. (Pubitemid 41436593)
14. Cailliatte, R.; Schkora, A.; Briat, J. F.; Mari, S.; Curie, C. (2010). High-affinity manganese uptake by the metal transporter NRAMP1 is essential for Arabidopsis growth in low manganese conditions. Plant Cell, 22, 904-917.
15. Dellagi, A.; Rigault, M.; Segond, D.; Roux, C.; Kraepiel, Y.; Cellier, F.; et al. (2005). Siderophore-mediated upregulation of Arabidopsis ferritin expression in response to Erwinia chrysanthemi infection. The Plant Journal, 43, 262-272. (Pubitemid 41009343)
16. Kumar, P.; Tewari, R. K.; Sharma, P. N. (2010). Sodium nitroprusside-mediated alleviation of iron deficiency and modulation of antioxidant responses in maize plants. AoB Plants plq002, doi: 10.1093/aobpla/plq002.
17. Vansuyt, G.; Lopez, F.; Inze, D.; Briat, J. F.; Fourcroy, P. (1997). Iron triggers a rapid induction of ascorbate peroxidase gene expression in Brassica napus. FEBS Letters, 410, 195-200. (Pubitemid 27304063)
18. Fourcroy, P.; Vansuyt, G.; Kushnir, S.; Inze, D.; Briat, J. F. (2004). Iron-regulated expression of a cytosolic ascorbate peroxidase encoded by the APX1 gene in Arabidopsis seedling. Plant Physiology, 134, 605-613. (Pubitemid 38261534)
19. Thimm, O.; Essigmann, B.; Kloska, S.; Altmann, T.; Buckhout, T. J. (2001). Response of Arabidopsis to iron deficiency stress as revealed by microarray analysis. Plant Physiology, 127, 1030-1043. (Pubitemid 33112163)
20. Zaharieva, T. B.; Abadia, J. (2003). Iron deficiency enhances the level of ascorbate, glutathione, and related enzymes in sugar beet roots. Protoplasma, 221, 269-275. (Pubitemid 36784917)
21. Jie, L.; Xu-Dong, W.; Shan-ting, H.; Xiu-Jie, W.; Hong-Qing, L. (2008). Proteomics response to iron deficiency in tomato root. Proteomics, 8, 2299-2311. (Pubitemid 351898034)
22. Mira, L.; Fernandez, M. T.; Santos, M.; Rocha, R.; Florencio, M. H.; Jennings, K. R. (2002). Interaction of flavonoids with iron and copper ions: a mechanism for the antioxidant activity. Free Radical Research, 36, 1199-1208. (Pubitemid 35230240)
23. Ebrahimzadeh, M. A.; Pourmorad, F.; Bekhradnia, A. R. (2008). Iron chelating activity screening, phenol and flavonoid content of some medicinal plants from Iran. African Journal of Biotechnology, 7, 3188-3192.
24. Jin, C. W.; He, X. X.; Zheng, S. J. (2007). The iron-deficiency induced phenolics accumulation may involve in regulation of Fe(III) chelate reductase in red clover. Plant Signalling and Behaviour, 2, 327-332.
25. Helmer, G.; Casadaban, M.; Bevan, M.; Kayes, L.; Chilton, M. D. (1984). A new chimeric gene as a marker for plant transformation: The expression of Escherichia coli β-galactosidase in sunflower and tobacco cell. Nature Biotechnology, 2, 520-527. (Pubitemid 15186586)
26. Singh, K.; Raizada, J.; Bhardwaj, P.; Ghawana, S.; Rani, A.; Singh, S. (2004). 26S rRNA-based internal control gene primer pair for reverse transcription-polymerase chain reaction-based quantitative expression studies in diverse plant species. Analytical Biochemistry, 335, 330-333. (Pubitemid 39535199)
27. Stephan, U. W.; Schmidke, I.; Stephan, V. W.; Scholz, G. (1996). The nicotianamine molecule is made-to-measure for complexation of metal micronutrients in plants. BioMetals, 9, 84-90.
28. Lichtenthaler, H. K. (1987). Chlorophylls and carotenoids: Pigments of photosynthetic biomembranes. Methods in Enzymology, 148, 350-382.
29. Wolfe, K.; Wu, X.; Liu, R. H. (2003). Antioxidant activity of apple peels. Journal of Agriculture and Food Chemistry, 51, 609-614.
30. Ordonez, A. L. L.; Gomez, J. D.; Vattuone, M. A.; Isla, Mi. (2006). Antioxidant activities of Sechium edule (Jacq.) swart extracts. Food Chemistry, 97, 452-458. (Pubitemid 43003748)
31. Sun, J. S.; Tsuang, Y. W.; Chen, I. J.; Huang, W. C.; Hang, Y. S.; LU, F. J. (1998). An ultra-weak chemiluminescence study of oxidative stress in rabbits following acute thermal injury. Burns, 24, 225-231. (Pubitemid 28316303)
32. Madhusudan, R.; Ravisankar, G. A. (1996). Gradients of anthocyanin in cell aggregates of Daucus carota in suspension cultures. Biotechnology Letters, 18, 1253-1256. (Pubitemid 26388552)
33. Ward, P. P.; Connelly, O. M. (2004). Lactoferrin: Role in iron homeostasis and host defense against microbial infection. BioMetals, 17, 2003-2008. (Pubitemid 38987138)
34. Curie, C.; Alonso, J. M.; Jean, M. L.; Ecker, J. R.; Briat, J. F. (2000). Involvement of NRAMP1 from Arabidopsis thaliana in iron transport. Biochemical Journal, 347, 749-755. (Pubitemid 30260965)
35. Briat, J. F.; Duc, C.; Ravet, k.; Gaymard, F. (2010). Ferritins and iron storage in plants. Biochimica et Biophysica Acta, 1800, 806-814.
36. Goto, F.; Yoshihara, T.; Shigemoto, N.; Toki, S.; Takaiwa, F. (1999). Iron fortification of rice seed by the soybean ferritin gene. Nature Biotechnology, 17, 282-286. (Pubitemid 29122636)
37. Lonnerdal, Bo. (2003). Genetically modified plants for improved trace element nutrition. Journal of Nutrition, 133, 1490S-1493S. (Pubitemid 36548733)
38. Mohamed, A.; Aly, A. A. (2004). Iron deficiency stimulated some enzymes activity, lipid peroxidation and free radicals production in Borage officinalis induced in vitro. International Journal of Agriculture and Biology, 6, 179-184.
39. Tewari, R. K.; Kumar, P.; Neetu, Sharma, P. N. (2005). Signs of oxidative stress in the chlorotic leaves of iron starved plants. Plant Science, 169, 1037-1045. (Pubitemid 41425695)
40. Yadav, S. K.; Singla-Pareek, S. L.; Reddy, M. K.; Sopory, S. K. (2005). Transgenic tobacco plants overexpressing glyoxalase enzymes resist an increase in methylglyoxal and maintain higher reduced glutathione levels under salinity stress. FEBS Letters, 579, 6265-6271. (Pubitemid 41548436)
41. Kumar, V.; Yadav, S. K. (2009). Proline and betaine provide protection to antioxidant and methylglyoxal detoxification systems during cold stress in Camellia sinensis (L.) O Kuntze. Acta Physiology Plantarum, 31, 261-269.
42. Boudet, A. M. (2007). Evolution and current status of research in phenolic compounds. Phytochemistry, 68, 2722-2735. (Pubitemid 350186173)
43. Petit, P.; Granier, T.; d'Estainot, B. L.; Manigand, C.; Bathany, K.; Schmitter, J. M.; et al. (2007). Crystal structure of grape dihydroflavonol 4-reductase: A key enzyme in flavonoid biosynthesis. Journal of Molecular Biology, 368, 1345-1357. (Pubitemid 46629082)