Pharmacological management of pediatric patients with sepsis

AACN Advanced Critical Care

Volumn 23, Issue 4, 2012, Pages 437-448

  Simmons, Marroyln L ^a   Durham, Spencer H ^a   Carter, Chenita W ^a  

^a Sacred Heart Children's Hospital   (United States)

Author keywords

Broad spectr um antibiotics; Cardiovascular support; Pediatrics; Sepsis

Indexed keywords

ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CARDIOTONIC AGENT; HYDROCORTISONE; INSULIN; VASOCONSTRICTOR AGENT;

DRUG EFFECT; HEMODYNAMICS; HUMAN; INTENSIVE CARE; METHODOLOGY; MORTALITY; NURSING; PATHOPHYSIOLOGY; PEDIATRICS; RESUSCITATION; REVIEW; SEPSIS;

ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CARDIOTONIC AGENTS; CRITICAL CARE; HEMODYNAMICS; HUMANS; HYDROCORTISONE; HYPOGLYCEMIC AGENTS; INSULIN; PEDIATRICS; RESUSCITATION; SEPSIS; VASOCONSTRICTOR AGENTS;

EID: 84871659968     PISSN: 15597768     EISSN: 15597776     Source Type: Journal    
DOI: 10.1097/NCI.0b013e31826ddccd     Document Type: Article

References (31)

1. Odetola FO, Gebremariam A, Freed GL. Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics. 2007;119(3): 487-494. (Pubitemid 46407517)
2. Bierley J, Carcillo J, Choong K, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med. 2009; 37(2):666-688.
3. Han Y, Carcillo J, Dragotta M, et al. Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics. 2003;112:793-799. (Pubitemid 37248685)
4. Goldstein B, Giroir B, Randolph A, et al. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8.
5. Kang-Birken SL, Dipiro JT. Sepsis and septic shock. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, eds. Pharmacotherapy: A Pathophysiologic Approach. 6th ed. New York, NY: McGraw-Hill; 2005:2131-2143.
6. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20: 864-874.
7. Neudeck BL, Rogers PD. Sepsis. In: Helms RA, Quan DJ, Herfindal ET, Gourley DR, eds. Textbook of Therapeutics: Drug and Disease Management. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006:2159-2171.
8. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554. (Pubitemid 36437931)
9. Nadal S. Severe pediatric sepsis. Expert Rev Anti Infect Ther. 2012;10(2):111-114.
10. Morrell M, Micek S, Kollef M. The management of severe sepsis and septic shock. Infect Dis Clin N Am. 2009;23: 485-501.
11. Aneja R, Carillo J. Differences between adult and pediatric septic shock. Minerva Anestesiol. 2011;77:986-992.
12. Irazuzta J, Sullivan K, Garcia P, Piva J. Pharmacologic support of infants and children in septic shock. J Pediatr (Rio J). 2007;83(2) (suppl):S36-S45. (Pubitemid 46920391)
13. Dellinger R, Levy M, Carlet J, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296-327.
14. Vincent J, Gottin L. Type of fluid in severe sepsis and septic shock. Minerva Anestesiol. 2011;77:1190-1196.
15. Ibrahim EH, Sherman G, Ward S, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118(1):146-155. (Pubitemid 30485502)
16. Kollef MH, Sherman G, Ward S, et al. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115(2): 263-274.
17. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589-1596. (Pubitemid 43810035)
18. Gallagher JC, MacDougall C. Antibiotics Simplified. 2nd ed. Sudbury, MA: Jones and Bartlett Learning; 2012.
19. Gilbert DN, Moellering RC Jr, Eliopoulos GM, Chambers HF, Saag MS, eds. The Sanford Guide to Antimicrobial Therapy. 40th ed. Sperryville, VA: Antimicrobial Therapy Inc; 2010.
20. Chalumeau M, Tonnelier S, D'Athis P, et al. Fluoroquinolone safety in pediatric patients: a prospective, multicenter, comparative cohort study in France. Pediatrics. 2003;111:e714-e719.
21. Yee CL, Duffy C, Gerbino PG, Stryker S, Noel GJ. Tendon or joint disorders in children after treatment with fluoroquinolones or azithromycin. Pediatr Infect Dis J. 2002;21: 525-529. (Pubitemid 34625833)
22. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Disease Pharmacists. Am J Health Syst Pharm. 2009;66(1):82-98.
23. Ellender T, Skinner JD. The use of vasopressors and inotropes in the emergency medical treatment of shock. Emerg Med Clin N Am. 2008;26:759-786. (Pubitemid 352004096)
24. Shapiro D, Loiacono L. Mean arterial pressure: therapeutic goals and pharmacologic support. Crit Care Clin. 2010;26:285-293.
25. Cooper B. Review and update on inotropes and vasopressors. AACN Adv Crit Care. 2008;19(1):5-15.
26. Irazuzta J, Sullivan KJ, Garcia PC, Piva JP. Pharmacologic support of infants and children in septic shock. J Pediatr (Rio J). 2007;83(2) (suppl):S36-S45. (Pubitemid 46920391)
27. Beale R, Hollenberg S, Jean-Louis V, Parrillo J. Vasopressor and inotropic support in septic shock: an evidence-based review. Crit Care Med. 2004;32(11) (suppl): S455-S465. (Pubitemid 39489021)
28. Irazuzta J, Pretzlaff R, Rowin M. Amrinone in pediatric refractory septic shock: an open-label pharmacodynamic study. Pediatr Crit Care Med. 2001;2(1):24-28.
29. Wynn J, Wong H. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol. 2010;37(2):439-479.
30. Neary N, Nieman L. Adrenal insufficiency-etiology, diagnosis, and treatment. Curr Opin Endocrinol Diabetes Obes. 2010;17(3):217-223.
31. Branco R, Tasker R, Garcia P, Piva J. Glycemic control and insulin therapy in sepsis and critical illness. J Pediatr (Rio J). 2007;83(5) (suppl):S128-S136.