Hepatitis B specific T cell immunity induced by primary vaccination persists independently of the protective serum antibody level

Vaccine

Volumn 31, Issue 3, 2013, Pages 506-513

  Carollo, Maria ^a   Palazzo, Raffaella ^a   Bianco, Manuela ^a   Pandolfi, Elisabetta ^b   Chionne, Paola ^a   Fedele, Giorgio ^a   Tozzi, Alberto Eugenio ^b   Carsetti, Rita ^b   Romanò, Luisa ^c   Ausiello, Clara Maria ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Ag specific blasts proliferation; Cytokines (IFN , IL 2); Hepatitis vaccination; Hexavac ; Infanrix hexa ; T cell responses; T memory subsets

Indexed keywords

CD4 ANTIGEN; CD45RA ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; DIPHTHERIA PERTUSSIS POLIOMYELITIS TETANUS HAEMOPHILUS INFLUENZAE TYPE B HEPATITIS B VACCINE; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 2;

ARTICLE; BLOOD LEVEL; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

CELL PROLIFERATION; CYTOKINES; DIPHTHERIA-TETANUS-PERTUSSIS VACCINE; HAEMOPHILUS VACCINES; HEPATITIS B ANTIBODIES; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HUMANS; IMMUNOLOGIC MEMORY; INFANT; ITALY; POLIOVIRUS VACCINE, INACTIVATED; T-LYMPHOCYTES; TIME FACTORS; VACCINES, COMBINED;

EID: 84871644293     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.11.029     Document Type: Article

References (37)

1. Chang M.H., Shau W.Y., Chen C.J., Wu T.C., Kong M.S., Liang D.C., et al. Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 2000, 284:3040-3042.
2. Rehermann B., Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005, 5:215-229.
3. Herkel J., Carambia A Let it B in viral hepatitis?. J Hepatol 2011, 55:5-7.
4. Lemon S.M., Thomas D.L. Vaccines to prevent viral hepatitis. N Engl J Med 1997, 336:196-204.
5. Huang L.M., Lu C.Y., Chen D.S. Hepatitis B virus infection, its sequelae, and prevention by vaccination. Curr Opin Immunol 2011, 23:237-243.
6. Scientific conclusions and grounds for the suspension of the marketing authorisation of Hexavac presented by the EMEA. http://ema.europe.eu/humandocs/PDFs/EPAR/Hexavac/Hexavac-H-298-Z-28-en.pdf.
7. Jorgensen P., Poethko-Müller C., Hellenbrand W., Jilg W., Thierfelder W., Meyer C., et al. Low hepatitis B immunogenicity of a hexavalent vaccine widely used in Germany: results of the German Health Survey for Children and Adolescents, 2003-2006. Epidemiol Infect 2010, 138:1621-1629.
8. Zanetti A.R., Romanò L., Giambi C., Pavan A., Carnelli V., Baitelli G., et al. Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study. Lancet Infect Dis 2010, 10:755-761.
9. Zielinski C.E., Corti D., Mele F., Pinto D., Lanzavecchia A., Sallusto F. Dissecting the human immunologic memory for pathogens. Immunol Rev 2011, 240:40-51.
10. Zhou X., McElhaney J.E. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 2012, 29:2169-2177.
11. Sallusto F., Lanzavecchia A. Memory in disguise. Nat Med 2010, 17:1182-1183.
12. Lanzavecchia A., Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005, 17:326-332.
13. Sallusto F., Kremmer E., Palermo B., Hoy A., Ponath P., Qin S., et al. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 1999, 29:2037-2045.
14. Harari A., Vallelian F., Pantaleo G. Phenotypic heterogeneity of antigen-specific CD4T cells under different conditions of antigen persistence and antigen load. Eur J Immunol 2004, 34:3525-3533.
15. Rosado M.M., Scarsella M., Pandolfi E., Cascioli S., Giorda E., Chionne P., et al. Switched memory B cells maintain specific memory independently of serum antibodies: the hepatitis B example. Eur J Immunol 2011, 41:1800-1808.
16. Ausiello C.M., Lande R., Urbani F., Di Carlo B., Stefanelli P., Salmaso S., et al. Cell-mediated immunity and antibody responses to Bordetella pertussis antigens in children with a history of pertussis infection and in recipients of an acellular pertussis vaccine. J Infect Dis 2000, 181:1989-1995.
17. Carollo M., Palazzo R., Bianco M., Smits K., Mascart F., Ausiello C.M. Antigen-specific responses assessment for the evaluation of Bordetella pertussis T cell immunity in humans. Vaccine 2012, 30:1667-1674.
18. Cosmi L., Maggi L., Santarlasci V., Liotta F., Frosali F., Angeli R., et al. Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis. Int Arch Allergy Immunol 2007, 143:1-9.
19. Palazzo R., Spensieri F., Massari M., Fedele G., Frasca L., Carrara S., et al. Use of whole-blood samples in in-house bulk and single-cell antigen-specific gamma interferon assays for surveillance of Mycobacterium tuberculosis infections. Clin Vaccine Immunol 2008, 15:327-337.
20. Wilkinson T.M., Li C.K., Chui C.S., Huang A.K., Perkins M., Liebner J.C., et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med 2012, 18:274-278.
21. Honorati M.C., Dolzani P., Mariani E., Piacentini A., Lisignoli G., Ferrari C., et al. Epitope specificity of Th0/Th2 CD4+ T-lymphocyte clones induced by vaccination with rHBsAg vaccine. Gastroenterology 1997, 112:2017-2027.
22. Gourley T.S., Wherry E.J., Masopust D., Ahmed R. Generation and maintenance of immunological memory. Semin Immunol 2004, 16:323-333.
23. Bussmann B.M., Reiche S., Bieniek B., Krznaric I., Ackermann F., Jassoy C. Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV. Virology 2010, 397:7-13.
24. Sun J.C., Bevan M.J. Defective CD8T cell memory following acute infection without CD4T cell help. Science 2003, 300:339-342.
25. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., et al. Restoring function in exhausted CD8T cells during chronic viral infection. Nature 2006, 439:682-687.
26. Op Den Brouw M.L., Binda R.S., van Roosmalen M.H., Protzer U., Janssen H.L., van der Molen R.G., et al. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus. Immunology 2009, 126:280-289.
27. Yang P.L., Althage A., Chung J., Maier H., Wieland S., Isogawa M., et al. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci USA 2009, 107:798-802.
28. Cruz S.C., Souza S.L., Cruz A.C., Silva G.P., Milagres L.G. Human antibody and memory B and T-cell responses after primary and booster immunisation against Neisseria meningitidis B. Vaccine 2011, 29:7387-7394.
29. Barbey C., Pradervand E., Barbier N., Spertini F. Ex vivo monitoring of antigen-specific CD4+ T cells after recall immunization with tetanus toxoid. Clin Vaccine Immunol 2007, 14:1108-1116.
30. Kaveh D.A., Bachy V.S., Hewinson R.G., Hogarth P.J. Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge. PLoS One 2011, 6:e21566.
31. Bauer T., Jilg W. Hepatitis B surface antigen-specific T and B cell memory in individuals who had lost protective antibodies after hepatitis B vaccination. Vaccine 2006, 24:572-577.
32. Testi R., D'Ambrosio D., De Maria R., Santoni A. The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 1994, 15:479-483.
33. Ni Y.H., Huang L.M., Chang M.H., Yen C.J., Lu C.Y., You S.L., et al. Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies. Gastroenterology 2007, 132:1287-1293.
34. Craven D.E., Awdeh Z.L., Kunches L.M., Yunis E.J., Dienstag J.L., Werner B.G., et al. Nonresponsiveness to hepatitis B vaccine in health care workers. Results of revaccination and genetic typings. Ann Intern Med 1986, 105:356-360.
35. del Pozo Balado Mdel M., Leal M., Méndez Lagares G., Mata R.C., López-Cortés L.F., Viciana P., et al. Increased regulatory T cell counts in HIV-infected nonresponders to hepatitis B virus vaccine. J Infect Dis 2010, 202:362-369.
36. Yang Z., Wang L., Niu W., Wu Y., Zhang J., Meng G. Increased CD4+ CD25+ FoxP3+ regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization. Clin Immunol 2008, 127:265-266.
37. Giambi C., Bella A., Barale A., Montù D., Marchisio M., Oddone M., et al. A cohort study to evaluate persistence of hepatitis B immunogenicity after administration of hexavalent vaccines. BMC Infect Dis 2008, 28:100-1007.