Solid dispersion of ursolic acid in Gelucire 50/13: A strategy to enhance drug release and trypanocidal activity

AAPS PharmSciTech

Volumn 13, Issue 4, 2012, Pages 1436-1445

  De Oliveira Eloy, Josimar ^a   Saraiva, Juliana ^a   De Albuquerque, Sergio ^a   Marchetti, Juliana Maldonado ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chagas disease; Gelucire 50 13; solid dispersions; solvent evaporation method; ursolic acid

Indexed keywords

ADJUVANT; ANTITRYPANOSOMAL AGENT; DRUG CARRIER; GELUCIRE; GELUCIRE 13; GELUCIRE 50; SILICON DIOXIDE; UNCLASSIFIED DRUG; URSOLIC ACID; WATER;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL LINE; CHAGAS DISEASE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ACTIVITY; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; FIBROBLAST; HOT STAGE MICROSCOPY; INFRARED SPECTROSCOPY; LABORATORY DEVICE; MICROSCOPE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ROOM TEMPERATURE; SOLID; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; X RAY DIFFRACTION;

BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHAGAS DISEASE; DRUG CARRIERS; FATS; FIBROBLASTS; OILS; PARTICLE SIZE; PERMEABILITY; SILICON DIOXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE-ACTIVE AGENTS; TRITERPENES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; WATER; X-RAY DIFFRACTION;

EID: 84871641107     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9868-2     Document Type: Article

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