Pressure overload regulates expression of cytokines, γh2ax, and growth arrest-and dna-damage inducible protein 153 via glycogen synthase kinase-3β in ischemic-reperfused hearts

Hypertension

Volumn 61, Issue 1, 2013, Pages 95-104

  Baban, Babak ^a   Liu, Jun Yao ^a   Mozaffari, Mahmood S ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

H2AX; apoptosis; cytokine; glycogen synthase kinase 3 ; growth arrest and DNA damage inducible protein 153; heart; ischemia reperfusion; necrosis

Indexed keywords

5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; CARBOCYANINE; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HISTONE H2AX; INTERLEUKIN 10; INTERLEUKIN 17; LIPOCORTIN 5; LITHIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME PHOSPHORYLATION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION;

ANIMALS; ANOXIA; CYTOKINES; GLYCOGEN SYNTHASE KINASE 3; HEART; HISTONES; LITHIUM CHLORIDE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTOR CHOP;

EID: 84871615801     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.00028     Document Type: Article

References (42)

1. Arslan F, de Kleijn DP, Pasterkamp G. Innate immune signaling in cardiac ischemia. Nat Rev Cardiol. 2011;8:292-300.
2. Hohensinner PJ, Niessner A, Huber K, Weyand CM, Wojta J. Infammation and cardiac outcome. Curr Opin Infect Dis. 2011;24:259-264.
3. Valeur HS, Valen G. Innate immunity and myocardial adaptation to ischemia. Basic Res Cardiol. 2009;104:22-32.
4. Mann DL. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res. 2011;108:1133-1145.
5. Ha T, Liu L, Kelley J, Kao R, Williams D, Li C. Toll-like receptors: new players in myocardial ischemia/reperfusion injury. Antioxid Redox Signal. 2011;15:1875-1893.
6. Taqueti VR, Mitchell RN, Lichtman AH. Protecting the pump: controlling myocardial infammatory responses. Annu Rev Physiol. 2006;68:67-95.
7. Wang M, Baker L, Tsai BM, Meldrum KK, Meldrum DR. Sex differences in the myocardial infammatory response to ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 2005;288:E321-E326. (Pubitemid 40110638)
8. Herrmann JL, Markel TA, Abarbanell AM, Weil BR, Wang M, Wang Y, Tan J, Meldrum DR. Proinfammatory stem cell signaling in cardiac ischemia. Antioxid Redox Signal. 2009;11:1883-1896.
9. Miura T, Tanno M, Sato T. Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis. Cardiovasc Res. 2010;88:7-15.
10. Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S, Sollott SJ. Role of glycogen synthase kinase-3β in cardioprotection. Circ Res. 2009;104:1240-1252.
11. Murphy E, Steenbergen C. Inhibition of GSK-3β as a target for cardiopro-tection: the importance of timing, location, duration and degree of inhibition. Expert Opin Ther Targets. 2005;9:447-456. (Pubitemid 40883146)
12. Meares GP, Mines MA, Beurel E, Eom TY, Song L, Zmijewska AA, Jope RS. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Exp Cell Res. 2011;317:1621-1628.
13. Liu CB, Chen LH, Cheng AC, Chen WJ, Tsai ML, Liu Y, Ho CT, Pan MH. Hexahydro-β-acids induce apoptosis through mitochondrial pathway, GADD153 expression, and caspase activation in human leukemia cells. Food Chem Toxicol. 2011;49:1033-1042.
14. Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Precht TA, Esch EA, Heidenreich KA. Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen syn-thase kinase-3 β and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol Cell Neurosci. 2006;32:242-253. (Pubitemid 44016066)
15. Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y. C/EBP homologous protein defciency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and infammation. Arterioscler Thromb Vasc Biol. 2011;31:1124-1132.
16. Mozaffari MS, Baban B, Liu JY, Abebe W, Sullivan JC, El-Marakby A. Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts. Basic Res Cardiol. 2011;106:287-297.
17. Mozaffari MS, Patel C, Schaffer SW. Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel. Hypertension. 2006;47:912-919. (Pubitemid 44297563)
18. Mozaffari MS, Liu JY, Schaffer SW. Effect of pressure overload on car-dioprotection via PI3K-Akt: comparison of postconditioning, insulin, and pressure unloading. Am J Hypertens. 2010;23:668-674.
19. Mozaffari MS, Schaffer SW. Effect of pressure overload on cardioprotec-tion of mitochondrial KATP channels and GSK-3β: interaction with the MPT pore. Am J Hypertens. 2008;21:570-575. (Pubitemid 351589679)
20. Mozaffari MS, Baban B, Abdelsayed R, Liu JY, Wimborne H, Rodriguez N, Abebe W. Renal and glycemic effects of high-dose chromium pico-linate in db/db mice: assessment of DNA damage. J Nutr Biochem. 2012;23:977-985.
21. Yang ES, Nowsheen S, Wang T, Thotala DK, Xia F. Glycogen synthase kinase 3β inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons. Neuro-oncology. 2011;13:459-470.
22. Mellor AL, Baban B, Chandler P, Marshall B, Jhaver K, Hansen A, Koni PA, Iwashima M, Munn DH. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol. 2003;171:1652-1655. (Pubitemid 36966447)
23. Baban B, Chandler PR, Johnson BA 3rd, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL. Physiologic control of IDO competence in splenic dendritic cells. J Immunol. 2011;187: 2329-2335.
24. Cossarizza A, Salvioli S. Flow cytometric analysis of mitochondrial membrane potential using JC-1. Curr Protoc Cytom. 2001;Chapter 9:Unit 9.14.
25. Mathur A, Hong Y, Kemp BK, Barrientos AA, Erusalimsky JD. Evaluation of fuorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes. Cardiovasc Res. 2000;46:126-138. (Pubitemid 30155953)
26. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow7 cytometric detection of phosphatidylserine expression on early apoptotic cells using fuorescein labeled Annexin V. J Immunol Methods. 1995;184:39-51.
27. Dugo L, Collin M, Thiemermann C. Glycogen synthase kinase 3β as a target for the therapy of shock and infammation. Shock. 2007;27:113-123. (Pubitemid 46105826)
28. Klamer G, Song E, Ko KH, O'Brien TA, Dolnikov A. Using small molecule GSK3β inhibitors to treat infammation. Curr Med Chem. 2010;17:2873-2881.
29. Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol. 2005;6:777-784. (Pubitemid 43090463)
30. Whittle BJ, Varga C, Pósa A, Molnár A, Collin M, Thiemermann C. Reduction of experimental colitis in the rat by inhibitors of glycogen syn-thase kinase-3β. Br J Pharmacol. 2006;147:575-582. (Pubitemid 43355056)
31. Gao HK, Yin Z, Zhou N, Feng XY, Gao F, Wang HC. Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of infammation and apoptosis. J Cardiovasc Pharmacol. 2008;52:286-292.
32. Nian M, Lee P, Khaper N, Liu P. Infammatory cytokines and postmyocar-dial infarction remodeling. Circ Res. 2004;94:1543-1553. (Pubitemid 38856961)
33. D'Acquisto F, Maione F, Pederzoli-Ribeil M. From IL-15 to IL-33: the never-ending list of new players in infammation. Is it time to forget the humble aspirin and move ahead? Biochem Pharmacol. 2010;79:525-534.
34. Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010;10:479-489.
35. Eustace A, Smyth LJ, Mitchell L, Williamson K, Plumb J, Singh D. Identifcation of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest. 2011;139:1089-1100.
36. Frangogiannis NG, Mendoza LH, Lindsey ML, Ballantyne CM, Michael LH, Smith CW, Entman ML. IL-10 is induced in the reper-fused myocardium and may modulate the reaction to injury. J Immunol. 2000;165:2798-2808. (Pubitemid 30660731)
37. Manukyan MC, Alvernaz CH, Poynter JA, Wang Y, Brewster BD, Weil BR, Abarbanell AM, Herrmann JL, Crowe BJ, Keck AC, Meldrum DR. Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery. 2011;150:231-239.
38. Sylvester SL, ap Rhys CM, Luethy-Martindale JD, Holbrook NJ. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. J Biol Chem. 1994;269: 20119-20125.
39. Cheng WP, Hung HF, Wang BW, Shyu KG. The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch. Cardiovasc Res. 2008;77:551-559.
40. Cheng WP, Wang BW, Shyu KG. Regulation of GADD153 induced by mechanical stress in cardiomyocytes. Eur J Clin Invest. 2009;39: 960-971.
41. Lee MJ, Kwak YK, You KR, Lee BH, Kim DG. Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury. Exp Mol Med. 2009;41:243-252.
42. Zhang Y, Xia Z, La Cour KH, Ren J. Activation of Akt rescues endoplas-mic reticulum stress-impaired murine cardiac contractile function via glycogen synthase kinase-3β-mediated suppression of mitochondrial permeation pore opening. Antioxid Redox Signal. 2011;15:2407-2424.