Interaction of γ-glutamyltranspeptidase with ibuprofen-S-acyl- glutathione in vitro and in vivo in human

Drug Metabolism and Disposition

Volumn 41, Issue 1, 2013, Pages 111-121

  Grillo, Mark P ^a   Lohr, Michelle Tadano ^a,b   Khera, Smriti ^a,c  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AGILENT TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GAMMA GLUTAMYLTRANSFERASE; GLYCINE; IBUPROFEN; IBUPROFEN DERIVATIVE; IBUPROFEN N ACYL CYSTEINYLGLYCINE; IBUPROFEN S ACYL N ACETYLCYSTEINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EXCRETION; DRUG RETENTION; DRUG STRUCTURE; DRUG URINE LEVEL; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME KINETICS; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; METABOLITE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INTERACTION; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; CATTLE; CHROMATOGRAPHY, LIQUID; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HUMANS; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; TANDEM MASS SPECTROMETRY;

BOVINAE;

EID: 84871599836     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.048645     Document Type: Article

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