γ-Glutamyltranspeptidase-mediated degradation of diclofenac-s-acyl- glutathione in vitro and in vivo in rat

Chemical Research in Toxicology

Volumn 21, Issue 10, 2008, Pages 1933-1938

  Grillo, Mark P ^a,c   Hua, Fengmei ^a   March, Kristi L ^b   Benet, Leslie Z ^b   Knutson, Charles G ^a   Ware, Joseph A ^a,d  

^a PFIZER INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMGEN INC   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; DICLOFENAC N ACYL CYSTEINYLGLYCINE; DICLOFENAC S ACYL GLUTATHIONE; DRUG METABOLITE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIALYSIS; DRUG DEGRADATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; BILE; DICLOFENAC; DIPEPTIDES; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 55949097873     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx800073p     Document Type: Article

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