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Volumn 17, Issue 12, 2012, Pages 14733-14747

MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway

Author keywords

Bcl xL; MiR491 5p; PI 3K Akt; STAT3; TP53

Indexed keywords

BCL2L1 PROTEIN, HUMAN; MICRORNA; MIRN491 MICRORNA, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL X; PROTEIN P53; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

EID: 84871591875     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171214733     Document Type: Article
Times cited : (71)

References (31)
  • 1
    • 27244432205 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • Chen, C.Z. MicroRNAs as oncogenes and tumor suppressors. N. Engl. J. Med. 2005, 353, 1768-1771.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1768-1771
    • Chen, C.Z.1
  • 2
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
    • (2007) Toxicol. Pathol. , vol.35 , pp. 495-516
    • Elmore, S.1
  • 4
    • 0033396491 scopus 로고    scopus 로고
    • Fas ligand-induced apoptosis
    • Nagata, S. Fas ligand-induced apoptosis. Annu. Rev. Genet. 1999, 33, 29-55.
    • (1999) Annu. Rev. Genet. , vol.33 , pp. 29-55
    • Nagata, S.1
  • 5
    • 0037276437 scopus 로고    scopus 로고
    • The CD95(APO-1/Fas) DISC and beyond
    • Peter, M.E.; Krammer, P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 2003, 10, 26-35.
    • (2003) Cell Death Differ. , vol.10 , pp. 26-35
    • Peter, M.E.1    Krammer, P.H.2
  • 6
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • Acehan, D.; Jiang, X.; Morgan, D.G.; Heuser, J.E.; Wang, X.; Akey, C.W. Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation. Mol. Cell 2002, 9, 423-432.
    • (2002) Mol. Cell , vol.9 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 7
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle, R.J.; Strasser, A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 9
    • 84863645097 scopus 로고    scopus 로고
    • A review on the role of microRNA in biology, diagnosis, and treatment of pancreatic adenocarcinoma
    • Papaconstantinou, I.G.; Lykoudis, P.M.; Gazouli, M.; Manta, A.; Polymeneas, G.; Voros, D. A review on the role of microRNA in biology, diagnosis, and treatment of pancreatic adenocarcinoma. Pancreas 2012, 41, 671-677.
    • (2012) Pancreas , vol.41 , pp. 671-677
    • Papaconstantinou, I.G.1    Lykoudis, P.M.2    Gazouli, M.3    Manta, A.4    Polymeneas, G.5    Voros, D.6
  • 10
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • Zou, H.; Li, Y.; Liu, X.; Wang, X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 1999, 274, 11549-11556.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4
  • 12
    • 77956358309 scopus 로고    scopus 로고
    • Pancreatic cancer: Epidemiology and risk factors
    • Krejs, G.J. Pancreatic cancer: Epidemiology and risk factors. Dig. Dis. 2010, 28, 355-358.
    • (2010) Dig. Dis. , vol.28 , pp. 355-358
    • Krejs, G.J.1
  • 14
    • 80054826238 scopus 로고    scopus 로고
    • MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease
    • Wang, J.; Sen, S. MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease. J. Biosci. 2011, 36, 481-491.
    • (2011) J. Biosci. , vol.36 , pp. 481-491
    • Wang, J.1    Sen, S.2
  • 17
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • Szafranska, A.E.; Davison, T.S.; John, J.; Cannon, T.; Sipos, B.; Maghnouj, A.; Labourier, E.; Hahn, S.A. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 2007, 26, 4442-4452.
    • (2007) Oncogene , vol.26 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3    Cannon, T.4    Sipos, B.5    Maghnouj, A.6    Labourier, E.7    Hahn, S.A.8
  • 19
    • 84867403952 scopus 로고    scopus 로고
    • MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer
    • Ali, S.; Saleh, H.; Sethi, S.; Sarkar, F.H.; Philip, P.A. MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer. Br. J. Cancer 2012, 107, 1354-1360.
    • (2012) Br. J. Cancer , vol.107 , pp. 1354-1360
    • Ali, S.1    Saleh, H.2    Sethi, S.3    Sarkar, F.H.4    Philip, P.A.5
  • 21
    • 77955492383 scopus 로고    scopus 로고
    • Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells
    • Nakano, H.; Miyazawa, T.; Kinoshita, K.; Yamada, Y.; Yoshida, T. Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells. Int. J. Cancer 2010, 127, 1072-1080.
    • (2010) Int. J. Cancer , vol.127 , pp. 1072-1080
    • Nakano, H.1    Miyazawa, T.2    Kinoshita, K.3    Yamada, Y.4    Yoshida, T.5
  • 23
    • 77955983894 scopus 로고    scopus 로고
    • Functional and biological analysis of Bcl-xL expression in human osteosarcoma
    • Wang, Z.X.; Yang, J.S.; Pan, X.; Wang, J.R.; Li, J.; Yin, Y.M.; De, W. Functional and biological analysis of Bcl-xL expression in human osteosarcoma. Bone 2010, 47, 445-454.
    • (2010) Bone , vol.47 , pp. 445-454
    • Wang, Z.X.1    Yang, J.S.2    Pan, X.3    Wang, J.R.4    Li, J.5    Yin, Y.M.6    De, W.7
  • 24
    • 0032763060 scopus 로고    scopus 로고
    • Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model
    • Liu, R.; Page, C.; Beidler, D.R.; Wicha, M.S.; Nunez, G. Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model. Am. J. Pathol. 1999, 155, 1861-1867.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1861-1867
    • Liu, R.1    Page, C.2    Beidler, D.R.3    Wicha, M.S.4    Nunez, G.5
  • 25
    • 0034352334 scopus 로고    scopus 로고
    • Regulation of Bcl-xL: A little bit of this and a little bit of STAT
    • Grad, J.M.; Zeng, X.R.; Boise, L.H. Regulation of Bcl-xL: A little bit of this and a little bit of STAT. Curr. Opin. Oncol. 2000, 12, 543-549.
    • (2000) Curr. Opin. Oncol. , vol.12 , pp. 543-549
    • Grad, J.M.1    Zeng, X.R.2    Boise, L.H.3
  • 26
    • 0034725080 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase
    • Tang, X.; Downes, C.P.; Whetton, A.D.; Owen-Lynch, P.J. Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase. J. Biol. Chem. 2000, 275, 13142-13148.
    • (2000) J. Biol. Chem. , vol.275 , pp. 13142-13148
    • Tang, X.1    Downes, C.P.2    Whetton, A.D.3    Owen-Lynch, P.J.4
  • 29
    • 58149481148 scopus 로고    scopus 로고
    • Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
    • Qian, J.; Zou, Y.; Rahman, J.S.; Lu, B.; Massion, P.P. Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol. Cancer Ther. 2009, 8, 101-109.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 101-109
    • Qian, J.1    Zou, Y.2    Rahman, J.S.3    Lu, B.4    Massion, P.P.5
  • 31
    • 0030978319 scopus 로고    scopus 로고
    • A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability
    • Ishiyama, M.; Miyazono, Y.; Sasamoto, K.; Ohkura, Y.; Ueno, K. A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta 1997, 44, 1299-1305.
    • (1997) Talanta , vol.44 , pp. 1299-1305
    • Ishiyama, M.1    Miyazono, Y.2    Sasamoto, K.3    Ohkura, Y.4    Ueno, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.