The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43639-43650

  Chu, Po Chen ^a   Chuang, Hsiao Ching ^a   Kulp, Samuel K ^a   Chen, Ching Shih ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; CANCER CELLS; CANCER THERAPY; CO-IMMUNOPRECIPITATIONS; CYTOPLASMIC LOCALIZATION; DEGRADATION PATHWAYS; DIVERSE STRESS; DOMINANT NEGATIVE; E3 LIGASE; GLUCOSE TRANSPORTERS; GST PULL-DOWN; HEAT-SHOCK; IN-VITRO; MECHANISTIC LINK; METABOLIC STRESS; MUTATIONAL ANALYSIS; NOVEL STRATEGIES; NUCLEAR EXPORT; ONCOGENIC PROTEINS; POST-TRANSLATIONAL MODIFICATIONS; PROTEASOMAL DEGRADATION; PROTECTIVE EFFECTS; PROTEIN STABILITY; RECOGNITION SITE; RNA-RECOGNITION MOTIFS; STRESS RESPONSE PROTEINS; STRESS STIMULUS; UBIQUITIN; UBIQUITINATION;

AMINO ACIDS; BIOELECTRIC POTENTIALS; CELLS; CYTOLOGY; PATHOLOGY; PHOSPHORYLATION; RNA;

PROTEINS;

HUR PROTEIN; I KAPPA B KINASE ALPHA; MESSENGER RNA; PROTEIN KINASE C ALPHA; PROTEIN TRCP1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MALE; METABOLIC STRESS; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TARGETING; PROTEIN TRANSPORT; UBIQUITINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; ANTINEOPLASTIC AGENTS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; BINDING SITES; CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; GLYCOLYSIS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; I-KAPPA B KINASE; MALE; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN BINDING; PROTEOLYSIS; UBIQUITINATION;

EID: 84871589889     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.393678     Document Type: Article

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