Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

Hepatology

Volumn 55, Issue 4, 2012, Pages 1237-1248

  Embade, Nieves ^a   Fernández Ramos, David ^a   Varela Rey, Marta ^a   Beraza, Naiara ^a   Sini, Marcella ^a   de Juan, Virginia Gutiérrez ^a   Woodhoo, Ashwin ^a   Martínez López, Nuria ^a   Rodríguez Iruretagoyena, Begoña ^a   Bustamante, Francisco Javier ^b   de la Hoz, Ana Belén ^c   Carracedo, Arkaitz ^a,d   Xirodimas, Dimitris P ^e   Rodríguez, Manuel S ^a   Lu, Shelly C ^f   Mato, José M ^a   Martínez Chantar, María L ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL DE CRUCES   (Spain)

^c Midatech Biogune SL   (Spain)

^d BASQUE FOUNDATION FOR SCIENCE   (Spain)

^e CNRS   (France)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUR PROTEIN; LYSINE; NEDD8 PROTEIN; PROTEIN MDM2;

ANIMAL CELL; ARTICLE; CANCER SURGERY; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEPATOMA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; METASTASIS; NEDDYLATION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; CYTOPLASM; DISEASE MODELS, ANIMAL; HEPATOCYTES; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; UBIQUITINS;

EID: 84859158017     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24795     Document Type: Article

References (34)

1. Brennan CM, Steitz JA. HuR and mRNA stability. Cell Mol Life Sci 2001; 58: 266-277.
2. Levine TD, Gao F, King PH, Andrews LG, Keene JD. Hel-N1: an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol 1993; 13: 3494-3504.
3. Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 2000; 19: 2340-2350.
4. Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, Prescott SM. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest 2001; 108: 1657-1665.
5. Lopez de Silanes I, Lal A, Gorospe M. HuR: post-transcriptional paths to malignancy. RNA Biol 2005; 2: 11-13.
6. Abdelmohsen Koth GM. Posttranscriptional regulation of cancer traits by HuR. Interdisciplinary reviews RNA 2010; 1: 214-219.
7. Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 2010; 138: 1943-1953.
8. Kang MJ, Ryu BK, Lee MG, Han J, Lee JH, Ha TK, et al. NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis. Gastroenterology 2008; 135: 2030-2042, 2042.e1-3.
9. Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, et al. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J 2009; 28: 1271-1282.
10. Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 2004; 23: 1985-1997.
11. Xirodimas DP. Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem Soc Trans 2008; 36: 802-806.
12. Chan Y, Yoon J, Wu JT, Kim HJ, Pan KT, Yim J, Chien CT. DEN1 deneddylates non-cullin proteins in vivo. J Cell Sci 2008; 121: 3218-3223.
13. Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J 2005; 24: 1341-1351.
14. Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004; 118: 83-97.
15. Zhang MF, Zhang ZY, Fu J, Yang YF, Yun JP. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med 2009; 7: 110.
16. Medico E, Mongiovi AM, Huff J, Jelinek MA, Follenzi A, Gaudino G, et al. The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell 1996; 7: 495-504.
17. Martinez-Lopez N, Varela-Rey M, Fernandez-Ramos D, Woodhoo A, Vazquez-Chantada M, Embade N, et al. Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. HEPATOLOGY 2010; 52: 1621-1631.
18. Leffert HL, Koch KS, Moran T, Williams M. Liver cells. Methods Enzymol 1979; 58: 536-544.
19. Rodriguez MS, Desterro JM, Lain S, Midgley CA, Lane DP, Hay RT. SUMO-1 modification activates the transcriptional response of p53. EMBO J 1999; 18: 6455-6461.
20. Ginzinger DG. Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. Exp Hematol 2002; 30: 503-512.
21. Huggett J, Dheda K, Bustin S, Zumla A. Real-time RT-PCR normalisation; strategies and considerations. Genes Immun 2005; 6: 279-284.
22. Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, et al. HuR/methyl-HuR and AU-rich RNA binding factor 1 regulate the methionine adenosyltransferase expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 2010;138:1943-1953.
23. Beraza N, Ludde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology 2007; 132: 2504-2517.
24. Deb SP. Function and dysfunction of the human oncoprotein MDM2. Front Biosci 2002; 7: d235-243.
25. Morotti A, Mila S, Accornero P, Tagliabue E, Ponzetto C. K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 2002; 21: 4885-4893.
26. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A 2001; 98: 5560-5565.
27. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275: 8945-8951.
28. Xirodimas D, Saville MK, Edling C, Lane DP, Lain S. Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 2001; 20: 4972-4983.
29. Sundqvist A, Liu G, Mirsaliotis A, Xirodimas DP. Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep 2009; 10: 1132-1139.
30. Xirodimas DP, Stephen CW, Lane DP. Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53. Exp Cell Res 2001; 270: 66-77.
31. Fan XC, Steitz JA. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J 1998; 17: 3448-3460.
32. Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, et al. Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J 2011; 30: 1040-1053.
33. Gwizdek C, Hobeika M, Kus B, Ossareh-Nazari B, Dargemont C, Rodriguez MS. The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. J Biol Chem 2005; 280: 13401-13405.
34. Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009; 458: 732-736.