Physicochemical properties, in vitro release and in vivo evaluation of tramadol hydrochloride rectal suppository and rectal gel

Asian Biomedicine

Volumn 5, Issue 2, 2011, Pages 269-275

  Reanmongkol, Wantana ^a   Kaewnopparat, Nattha ^a   Ratanajamit, Chaveewan ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Analgesic; Rectal gel; Release study; Suppository; Tramadol

Indexed keywords

HYDROXYETHYLCELLULOSE; MACROGOL 400; POLOXAMER; TRAMADOL; WITEPSOL H 15;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; GEL; HOT PLATE TEST; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SUPPOSITORY;

EID: 84871573398     PISSN: 19057415     EISSN: 1875855X     Source Type: Journal    
DOI: 10.5372/1905-7415.0502.037     Document Type: Article

References (20)

1. Dayer P, Collart L, Desmeules J. The pharmacology of tramadol. Drugs. 1994; 47(Suppl):3-7. (Pubitemid 24132191)
2. Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004; 43:879-923. (Pubitemid 39447033)
3. Micromedex Healthcare Series: Document 2007. Tramadol. Available from: http://www.thomsonhc.com/hcs/librarian/ND-PR/Main/SBK/3/PFPUI/7z16hW4.
4. Petrone D, Kamin M, Olson W. Slowing the titration rate of tramadol HCl reduces the incidence of discontinuation due to nausea and/ or vomiting: a double-blind randomized trial. J Clin Pharm Ther. 1999; 24:115-23. (Pubitemid 29261263)
5. Mercadante S, Arcuri E, Fusco F, Tirelli W, Villari P, Bussolino C, Campa T, De Conno F, Ripamonti C. Randomized double-blind, double-dummy crossover clinical trial of oral tramadol versus rectal tramadol administration in opioid-naive cancer patients with pain. Support Care Cancer. 2005; 13:702-7. (Pubitemid 41435561)
6. Allen LV Jr. Compounding suppositories. Part I: theoretical considerations. Int J Pharm Compound. 2000; 4:289-93.
7. MIMS Thailand Index of Medical Specialties, 115th Edition, 2009.
8. British Pharmacopoeia 2007. CD version 11.0.
9. Yong CS, Oh YK, Jung SH, Rhee JD, Kim HD, Kim CK, Choi JS, Choi HG. Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol. Eur J Pharm Sci. 2004; 23:347-53. (Pubitemid 39573385)
10. Woolfe G, MacDonald AD. The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther. 1944; 80:300-7.
11. Yun MO, Choi HG, Jung JH, Kim CH. Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement. Int J Pharm. 1999; 189:137-45. (Pubitemid 29481749)
12. Allen, LV Jr. Featured excipient: The poloxamers. Int J Pharm Compound. 2002; 6:58-9.
13. Miller SC, Drabik BR Rheological properties of poloxamer vehicles. Int J Pharm. 1984; 18:269-79.
14. Choi HG, Lee MK, Kim MH, Kim CK. Effects of additives on the physicochemicasl properties of liquid suppository bases. Int J Pharm.1999; 190:13-9.
15. Barakat NS. In vitro and in vivo charecteristics of thermogelling rectal drug delivery. AAPS PharmSciTech. 2004; 10:724-31.
16. Choi HG, Oh YK, Kim CK. In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability. Int J Pharm. 1998; 165:23-32.
17. Hewitt WD. Compounded suppositories and pharmaceutical care. Int J Pharm Compound. 1997; 1:93-9.
18. Hosny EA, Abdeel-Hady SS, El-Tahir K. Formulation, in vitro release and ex vivo spasmolytic effects of mebeverine hydrochloride suppositories containing polycarbophil or polysorbate 80. Int J Pharm. 1996; 142:163-8. (Pubitemid 26354641)
19. LeBars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev. 2001; 53:597-652. (Pubitemid 33136239)
20. Sacerdote P, Bianchi M, Manfredi B, Panerai AE. Effects of tramadol on immune response and nociceptive thresholds in mice. Pain.1997; 72:325-30. (Pubitemid 27390731)