Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 Cells: Comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx

Molecular Pharmacology

Volumn 83, Issue 1, 2013, Pages 191-205

  Jarrard, Rachel E ^a   Wang, Yuchen ^a   Salyer, Amy E ^a   Pratt, Evan P S ^a   Soderling, Ian M ^a   Guerra, Marcy L ^a   Lange, Allison M ^a   Broderick, Hilary J ^a   Hockerman, Gregory H ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; 2' O ME CAMP AM 4 CHLOROPHENYLTHIO 2' O METHYLADENOSINE 3' 5' CYCLIC MONOPHOSPHATE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); BISINDOLYLMALEIMIDE; CYCLIC AMP DERIVATIVE; GLICLAZIDE; INOSITOL PHOSPHATE; NICARDIPINE; PHOSPHOLIPASE C; THAPSIGARGIN; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR CALCIUM; INSULIN RELEASE; MEMBRANE POTENTIAL; PRIORITY JOURNAL;

ANIMALS; BORON COMPOUNDS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL LINE, TUMOR; CYCLIC AMP; DRUG SYNERGISM; ENZYME ACTIVATION; GLICLAZIDE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; INTRACELLULAR SPACE; KATP CHANNELS; MALEIMIDES; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; TOLBUTAMIDE; TYPE C PHOSPHOLIPASES;

EID: 84871573246     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.081943     Document Type: Article

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