Microglial responses after focal radiation-induced injury are affected by α-difluoromethylornithine

International Journal of Radiation Oncology Biology Physics

Volumn 36, Issue 1, 1996, Pages 113-123

  Nakagawa, Minoru ^a   Bellinzona, Mattia ^a   Seilhan, Theresa M ^a   Gobbel, Glenn T ^a   Lamborn, Kathleen R ^a   Fike, John R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Astrocytes; Bromodeoxyuridine; DFMO; Immunohistochemistry; Interstitial irradiation; Labeling index; Microglia; Morphometric analysis; Normal brain

Indexed keywords

EFLORNITHINE; IODINE 125;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL STRUCTURE; DOG; DRUG UPTAKE; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; MALE; MICROGLIA; NERVE CELL LESION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RADIATION INJURY;

EID: 0029814114     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(96)00239-8     Document Type: Article

References (57)

1. P.C. Burger M.S.J. Mahaley L. Dudka F.S. Vogel The morphologic effects of radiation administered therapeutically for intracranial gliomas. A postmortem study of 25 cases Cancer 44 1979 1256 1272
2. W. Calvo J.W. Hopewell H.S. Reinhold T.K. Yeung Time- and dose-related changes in the white matter of the rat brain after single doses of x rays Br. J. Radiol. 61 1988 1043 1052
3. W.F. Caveness Pathology of radiation damage to the normal brain of the monkey NCI Monogr. 46 1977 57 76
4. H.W. Chalkley Method for the quantitative morphologic analysis of tissues J. natl. Cancer Inst. 4 1943 47 53
5. C.S. Chiang W.H. McBride Radiation enhances tumor necrosis factor-α production by murine brain cells Brain Res. 566 1991 265 269
6. C.S. Chiang W.H. McBride H.R. Withers Radiation-induced astrocytic and microglial responses in mouse brain Radiother. Oncol. 29 1993 60 68
7. E.J. Davis T.D. Foster W.E. Thomas Cellular forms and functions of brain microglia Brain Res. Bull. 34 1994 73 78
8. D.W. Dickson S.C. Lee L.A. Mattiace S.C. Yen C. Brosnan Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease Glia 7 1993 75 83
9. D.W. Dickson L.A. Mattiale K. Cure K. Hutchins W.D. Lyman C.F. Brosnan Microglia in human disease with an emphasis on acquired immune deficiency syndrome Lab. Invest. 64 1991 135 146
10. J.R. Fike C.E. Cann T.L. Phillips M. Bernstein P.H. Gutin K. Turowski K.A. Weaver R.L. Davis R.J. Higgins V. DaSilva Radiation brain damage induced by interstitial 125-I sources: A canine model evaluated by quantitative computed tomography Neurosurgery 16 1985 530 537
11. J.R. Fike G.T. Gobbel Central nervous system radiation injury in large animal models P.H. Gutin S.A. Leibel G.E. Sheline Radiation injury to the nervous system 1991 Raven Press, Ltd New York 113 135
12. J.R. Fike G.T. Gobbel D. Chou B.P.L. Wijnhoven M. Bellinzona M. Nakagawa T.M. Seilhan Cellular proliferation and infiltration following interstitial irradiation of normal dog brain is altered by an inhibitor of polyamine synthesis Int. J. Radiat. Oncol. Biol. Phys. 32 1995 1035 1045
13. J.R. Fike G.T. Gobbel L.J. Marton T.M. Seilhan Radiation brain injury is reduced by the polyamine inhibitor α-difluoromethylornithine (DFMO) Radiat. Res. 138 1994 99 106
14. K. Frei K. Nohava U.V. Malipiero C. Schwerdel A. Fontana Production of macrophage colony-stimulating factor by astrocytes and brain macrophages J. Neuroimmunol. 40 1992 189 196
15. D. Giulian Ameboid microglia as effectors of inflammation in the central nervous system J. Neurosci. Res. 18 1987 155 171
16. D. Giulian T.J. Baker L.-C.N. Shih L.B. Lachman Interleukin-1 of the central nervous system is produced by amoeboid microglia J. Exp. Med. 164 1986 594 604
17. D. Giulian J. Chen J.E. Ingeman J.K. George M. Noponen The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain J. Neurosci. 9 1989 4416 4429
18. D. Giulian J.E. Ingeman Colony-stimulating factors as promoters of ameboid microglia J. Neurosci. 8 1988 4707 4717
19. D. Giulian B. Johnson J.F. Krebs J.K. George M. Tapscott Microglial mitogens are produced in the developing and injured mammalian brain J. Cell Biol. 112 1991 323 333
20. D. Giulian L.B. Lachman Interleukin-1 stimulation of astroglial proliferation after brain injury Science 228 1985 497 499
21. G.T. Gobbel L.J. Marton K. Lamborn T.M. Seilhan J.R. Fike Modification of radiation-induced brain injury by α-difluoromethylornithine (DFMO) Radiat. Res. 128 1991 306 315
22. H.G. Gratzner Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication Science 218 1982 474 475
23. P.H. Gutin S.A. Leibel W.M. Wara A. Choucair V.A. Levin T.L. Phillips P. Silver V. Da Silva M.S.B. Edwards R.L. Davis K.A. Weaver S. Lamb Recurrent malignant gliomas: Survival following interstitial brachytherapy with high-activity iodine-125 sources J. Neurosurg. 67 1987 864 873
24. R.F. Iacono M.I. Berrie E.F. Lascano A triple staining procedure to evaluate phagocytic role of differentiated astrocytes J. Neurosci. Methods. 39 1991 225 230
25. J. Janne L. Alhonen P. Leinonen Polyamines: From molecular biology to clinical applications Ann. Med. 23 1991 241 259
26. R.C. Janzer P. Kleihues C.B. Ostertag Early and late effects on the normal dog brain of permanent interstitial iridium-192 irradiation Acta Neuropathol. (Berl.) 70 1986 91 102
27. N. Kalderon A.A. Alfieri Z. Fuks Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue 1st Ed Proc. Natl. Acad. Sci. USA 87 1990 10058 10062
28. F. Kierszenbaum J.J. Wirth P.P. McCann A. Sjoerdsma Impairment of macrophage function by inhibitors of ornithine decarboxylase activity Infect. Immunol. 55 1987 2461 2464
29. P.M. Kochanek J.M. Hallenbeck Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke Stroke 23 1992 1367 1379
30. S. Kramer The hazards of therapeutic irradiation of the central nervous system Clin. Neurosurg. 15 1968 301 318
31. L. Lawson V. Perry S. Gordon Turnover of resident microglia in the normal adult mouse brain Neuroscience 48 1992 405 415
32. S.A. Leibel P.H. Gutin W.M. Wara P. Silver D.A. Larson M.S.B. Edwards S.A. Lamb B. Ham K.A. Weaver C. Barnett T.L. Phillips Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas Int. J. Radiat. Oncol. Biol. Phys. 17 1989 1129 1139
33. S. Leong E. Ling Amoeboid and ramified microglia: Their interrelationship and response to brain injury Glia 6 1992 39 47
34. E.A. Ling W.C. Wong The origin and nature of ramified and amoeboid microglia; A historical review and current concepts Glia 7 1993 9 18
35. P.S. Mamont M.C. Duchesne J. Grove P. Bey Antiproliferative properties of dl -α-difluoromethyl ornithine in cultured cells. A consequence of irreversible inhibition of ornithine decarboxylase Biochem. Biophys. Res. Commun. 81 1978 58 66
36. H. Mannoji H. Yeger L.E. Becker A specific histochemical marker (lectin Ricinus communis agglutinin-1) for normal human microglia, and application to routine histopathology Acta neuropathol. (Berl.) 71 1986 341 343
37. L. Messina G. Spampinato A. Arcidiacono L. Malaguarnera M. Pagano B. Kaminska L. Kaczmarek A. Messina Polyamine involvement in functional activation of human macrophages J. Leukoc. Biol. 52 1992 585 587
38. M. Mildenberger T.G. Beach E.G. McGeer C.M. Ludgate An animal model of prophylactic cranial irradiation: Histologic effects at acute, early and delayed stages int. J. Radiat. Oncol. Biol. Phys. 18 1990 1051 1060
39. C.E. Milligan P. Levitt T.J. Cunningham Brain macrophages and microglia respond differently to lesions of the developing and adult visual system J. Comp. Neurol. 314 1991 136 146
40. 3H-thymidine autoradiography Acta Histochem. Cytochem. 24 1991 457 463
41. M. Monte S. Klein M.A. Jasnis L. Davel I.D. Algranati E.S. de Lustig Inhibition of lymphocyte and tumor-induced angiogenesis by the administration of difluoromethylornithine Cancer J. 6 1993 147 150
42. K. Nakajima S. Kohsaka Functional roles of microglia in the brain Neurosci. Res. 17 1993 187 203
43. M. Oehmichen Inflammatory cells in the central nervous system Prog. Neuropathol. 5 1983 277 335
44. C.B. Ostertag K. Weigel P. Warnke G. Lombeck P. Kleihues Sequential morphological changes in the dog brain after interstitial iodine-125 irradiation Neurosurgery 13 1983 523 528
45. A.E. Pegg Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy Cancer Res. 48 1988 759 774
46. C.O. Scharfen P.K. Sneed W.M. Wara D.A. Larson T.L. Phillips M.D. Prados K.A. Weaver M. Malec P. Acord K.R. Lamborn S. Lamb B. Ham P.H. Gutin High activity iodine-125 interstitial implant for gliomas Int. J. Radiat. Oncol. Biol. Phys. 24 1992 583 591
47. T.E. Schultheiss L.C. Stephens Invited review: Permanent radiation myelopathy Br. J. Radiol. 65 1992 737 753
48. T.E. Schultheiss L.C. Stephens M.H. Maor Analysis of the histopathology of radiation myelopathy Int. J. Radiat. Oncol. Biol. Phys. 14 1988 27 32
49. B. Stea J.M. Buatti D.E. Stringer E.W. Gerner Inhibition of polyamine synthesis suppresses growth and γ-ray-induced sublethal and potentially lethal damage recovery in human tumor cells in culture Radiat. Oncol. Invest. 1 1993 41 49
50. A. Suzumura M. Sawada K. Mokuno K. Kato T. Marunouchi H. Yamamoto Effects of microglia-derived cytokines on astrocyte proliferation Rest. Neurol. Neurosci. 5 1993 347 352
51. W.E. Thomas Brain macrophages: Evaluation of microglia and their functions Brain Res. Rev. 17 1992 61 74
52. J.K. Tiller-Borcich J.R. Fike T.L. Phillips R.L. Davis Pathology of delayed radiation brain damage: An experimental canine model Radiat. Res. 110 1987 161 172
53. K. Turowski J.R. Fike C.E. Cann R.J. Higgins R.L. Davis P.H. Gutin T.L. Phillips K.A. Weaver Normal brain iodine-125 radiation damage: Effect of dose and irradiated volume in a canine model Radiology 158 1986 833 838
54. A.J. van der Kogel Central nervous system radiation injury in small animal models P.H. Gutin S.A. Leibel G.E. Sheline Radiation injury to the nervous system 1991 Raven Press, Ltd New York 91 111
55. M.D. Walker T.A. Strike G.F. Sheline An analysis of dose-effect relationships in the radiotherapy of malignant gliomas Int. J. Radiat. Oncol. Biol. Phys. 5 1979 1725 1731
56. B.C. Zook E.W. Bradley G.W. Casarett C.C. Rogers Pathologic findings in canine brain irradiated with fractionated fast neutrons or photons Radiat. Res. 84 1980 562 578
57. D. Zucker-Franklin A. Warfel G. Grusky B. Frangione D. Teitet Novel monocyte-like properties of microglia/astroglial cells Lab. Invest. 57 1987 176 185