Imaging of Primary Chondrosarcoma: Radiologic-Pathologic Correlation

Radiographics

Volumn 23, Issue 5, 2003, Pages 1245-1278

  Murphey, Mark D ^a,b,c   Walker, Eric A ^a   Wilson, Anthony J ^a,d   Kransdorf, Mark J ^e   Temple, H Thomas ^f   Gannon, Francis H ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e MAYO CLINIC   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Bone neoplasms, 40.321; Bone neoplasms, CT, 40.1211; Bone neoplasms, MR, 40.12141; Sarcoma, 40.321

Indexed keywords

ARCHITECTURE; BIOPSY; BONE METASTASIS; CANCER STAGING; CARTILAGE MATRIX; CHONDROSARCOMA; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; DIAGNOSTIC TEST; HUMAN; MESENCHYME; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGNOSIS; REVIEW; WATER CONTENT; BONE TUMOR; DIAGNOSTIC IMAGING; INFORMATION CENTER; METHODOLOGY; MILITARY MEDICINE; ORGANIZATION; PATHOLOGY; RADIOGRAPHY;

ACADEMIES AND INSTITUTES; ARCHIVES; BONE NEOPLASMS; CHONDROSARCOMA; DIAGNOSTIC IMAGING; HUMANS; MILITARY MEDICINE;

EID: 0242456127     PISSN: 02715333     EISSN: None     Source Type: Journal    
DOI: 10.1148/rg.235035134     Document Type: Review

References (134)

1. Resnick D, Kyriakos M, Greenway GD. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D, ed. Diagnosis of bone and joint disorders. 4th ed. Philadelphia, Pa: Saunders, 2002; 3897-3920.
2. Mirra JM. Intramedullary cartilage and chondroid-producing tumors. In: Mirra JM, ed. Bone tumors: clinical, radiologic, and pathologic correlations. Philadelphia, Pa: Lea & Febiger, 1989; 439-535.
3. Dorfman HD, Czerniak B. Malignant cartilage tumors. In: Gery L, ed. Bone tumors. St Louis, Mo: Mosby, 1998; 353-411.
4. Huvos AG. Chondrosarcoma including spindle-cell (dedifferentiated) and myxoid chondrosarcoma: mesenchymal chondrosarcoma. In: Mitchell J, ed. Bone tumors: diagnosis, treatment, and prognosis, 2nd ed. Philadelphia, Pa: Saunders, 1991; 343-393.
5. Jaffe HL. Tumors and tumorous conditions of the bones and joints. Philadelphia, Pa: Lea & Febiger, 1958; 315-340.
6. Lichtenstein L, Jaffe HL. Chondrosarcoma of the bone. Am J Pathol 1943; 19:553-589.
7. Hudson TH, Moser RP Jr, Gilkey FW, Aoki J. Chondrosarcoma. In: Moser RP Jr, ed. Cartilaginous tumors of the skeleton. Philadelphia, Pa: Hanley & Belfus, 1990; 155-205.
8. Rozeman LB, Hogendoorn PC, Bovee JV. Diagnosis and prognosis of chondrosarcoma of bone. Expert Rev Mol Diagn 2002; 2:461-472.
9. Aigner T. Towards a new understanding and classification of chondrogenic neoplasias of the skeleton: biochemistry and cell biology of chondrosarcoma and its variants. Virchows Arch 2002; 441:219-230.
10. Pring ME, Weber KL, Unni KK, Sim FH. Chondrosarcoma of the pelvis: a review of sixty-four cases. J Bone Joint Surg Am 2001; 11:1630-1642.
11. Marco RA, Gitelis S, Brebach GT, Healey JH. Cartilage tumors: evaluation and treatment. J Am Acad Orthop Surg 2000; 8:292-304.
12. Somers J, Faber LP. Chondroma and chondrosarcoma. Semin Thorac Cardiovasc Surg 1999; 11:270-277.
13. Murphey MD, Flemming DJ, Boyea SR, Bojescul JA, Sweet DE, Temple HT. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. RadioGraphics 1998; 18:1213-1245.
14. Brien EW, Mirra JM, Kerr R. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology, and clinical biology. I. The intramedullary cartilage tumors. Skeletal Radiol 1997; 26:325-353.
15. Campanacci M. Bone and soft tissue tumors. New York, NY: Springer-Verlag, 1991; 1-1131.
16. Evans HL, Ayala AG, Romsdahl MM. Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 1977; 40:818-831.
17. Mirra JM, Gold R, Downs J, Eckardt JJ. A new histologic approach to the differentiation of enchondroma and chondrosarcoma of the bones: a clinicopathologic analysis of 51 cases. Clin Orthop 1985; 201:214-237.
18. Mulder JD, Kroon HM, Schutte HE, Taconis WK, eds. Radiologic atlas of bone tumors. Amsterdam, the Netherlands: Elsevier, 1993; 377-421.
19. Sanerkin NG. The diagnosis and grading of chondrosarcoma of bone: a combined cytologic and histologic approach. Cancer 1980; 45:582-594.
20. Unni KK. Enchondroma and chondrosarcoma. In: Unni KK, ed. Dahlin's bone tumors: general aspects and data on 11,087 cases. 5th ed. Philadelphia, Pa: Lippincott-Raven, 1996; 71-109.
21. Flamming DJ, Murphey MD. Enchondroma and chondrosarcoma. Semin Musculoskelet Radiol 2000; 4:59-71.
22. Geirnaerdt MJ, Hermans J, Bloem JL, et al. Usefulness of radiology in differentiating enchondroma from central grade I chondrosarcoma. AJR Am J Roentgenol 1997; 169:1097-1104.
23. Hudson TM, Manaster BJ, Springfield DS, Spanier SS, Enneking WF, Hawkins IF Jr. Radiology of medullary chondrosarcoma: preoperative treatment planning. Skeletal Radiol 1983; 10:69-78.
24. Lodwick GS, Wilson AF, Farrell C, Virtama P, Ditrich F. Determining growth rates of focal lesions of bone from radiographs. Radiology 1980; 34:577-583.
25. Lodwick GS. The radiologist's role in the management of chondrosarcoma (editorial). Radiology 1984; 150:275.
26. Preidler KW, Brossmann J, Daenen B, et al. Measurements of cortical thickness in experimentally created endosteal bone lesions: a comparison of radiography, CT, MR imaging, and anatomic sections. AJR Am J Roentgenol 1997; 168:1501-1505.
27. Reiter FB, Ackerman LV, Staple TW. Central chondrosarcoma of the appendicular skeleton. Radiology 1972; 105:525-530.
28. Ragsdale BD, Sweet DE, Vinh TN. Radiology as gross pathology in evaluating chondroid lesions. Hum Pathol 1989; 20:930-951.
29. Rosenthal DI, Schiller AL, Mankin HJ. Chondrosarcoma: correlation of radiological and histological grade. Radiology 1984; 150:21-26.
30. Sweet DE, Madewell JE, Ragsdale BD. Radiologic and pathologic analysis of solitary bone lesions. III. Matrix patterns. Radiol Clin North Am 1981; 19:785-814.
31. West OC, Reinus WR, Wilson AJ. Quantitative analysis of the plain radiographic appearance of central chondrosarcoma of bone. Invest Radiol 1995; 30:440-447.
32. Hudson TM, Chew FS, Manaster BJ. Radionuclide bone scanning of medullary chondrosarcoma. AJR Am J Roentgenol 1982; 139:1071-1076.
33. Kobayashi H, Lotoura Y, Hosono M, et al. Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy. Clin Nucl Med 1995; 20:361-364.
34. Aoki J, Watanabe H, Shinozaki T, et al. FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology 2001; 219:774-777.
35. Feldman F, van Heertum R, Manos C. FDG PET scanning of benign and malignant musculoskeletal lesions. Skeletal Radiol 2003; 32:201-208.
36. Dehdashti F, Siegel BA, Griffeth LK, et al. Benign versus malignant intraosseous lesions: discrimination by means of PET with 2-(F-18) fluoro-2-deoxy-D-glucose. Radiology 1996; 200: 243-247.
37. Dietlein M, Feaux de Lacroix W, Neufang KF, Steinbrich W, Schmidt J. Assessment of the grading of cartilaginous tumors of the long tubular bones from the radiologic and pathologic viewpoint. Rontgenblatter 1990; 43:74-180. [German]
38. Crim JR, Seeger LL. Diagnosis of low-grade chondrosarcoma. Radiology 1993; 189:503-504.
39. Mayes GB, Wallace S, Bernardino ME. Computed tomography of chondrosarcoma. J Comput Tomogr 1981; 5:345-348.
40. Moser RP Jr, Gilkey FW, Madewell JE. Enchondroma. In: Moser RP Jr, ed. Cartilaginous tumors of the skeleton. Philadelphia, Pa: Hanley & Belfus, 1990; 8-35.
41. Aoki J, Sone S, Fujioka F, et al. MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr 1991; 15:1011-1016.
42. De Beuckeleer LH, De Schepper AM, Ramon F. Magnetic resonance imaging in cartilaginous tumors: is it useful or necessary? Skeletal Radiol 1996; 25:137-141.
43. De Beuckeleer LH, De Schepper AM, Ramon F, Somville J. Magnetic resonance imaging in cartilaginous tumors: a retrospective study of 79 patients. Eur J Radiol 1995; 21:34-40.
44. Geirnaerdt MJ, Bloem JL, Eulderink F, Hogendoorn PC, Taminiau AH. Cartilaginous tumors: correlation of gadolinium-enhanced MR imaging and histopathologic findings. Radiology 1993; 186:813-817.
45. Geirnaerdt MJ, Bloem JL, Van Der Woode H, Taminiau AH, Hogendoorn PC. Fast dynamic contrast-enhanced subtraction MR imaging allows differentiation of benign and low-grade malignant cartilaginous tumors (abstr). Radiology 1996;201(P):359.
46. Janzen L, Logan PM, O'Connell JX, Connell DG, Munk PL. Intramedullary chondroid tumors of bone: correlation of abnormal peritumoral marrow and soft-tissue MRI signal with tumor type. Skeletal Radiol 1997; 26:100-106.
47. Varma DG, Ayala AG, Carrasco CH, et al. Chondrosarcoma: MR imaging with pathologic correlation. RadioGraphics 1992; 12:687-704.
48. Walker CW, Moore TE. MR imaging of hyaline cartilage-containing tumors. Appl Radiol 1998; April:20-26.
49. Yaghmai I. Angiographic features of chondromas and chondrosarcomas. Skeletal Radiol 1978; 3:91-98.
50. Lagergren C, Linbom A, Soderberg G. The blood vessels of chondrosarcomas. Acta Radiol 1961; 55:321-328.
51. Huvos AG, Marcove RC. Chondrosarcoma in the young: a clinicopathologic analysis of 79 patients younger than 21 years of age. Am J Surg Pathol 1987; 11:930-942.
52. McAfee MK, Pairolero PC, Bergstralh EJ, et al. Chondrosarcoma of the chest wall: factors affecting survival. Ann Thorac Surg 1985; 40:535-541.
53. Meyer CA, White CS. Cartilaginous disorders of the chest. RadioGraphics 1998; 18:1109-1123.
54. Vieta JO, Maier HC. Tumors of the sternum. Int Abstr Surg 1962; June:513-525.
55. Pascuzzi CA, Dahlin DC, Clagett OT. Primary tumors of the ribs and sternum. Surg Gynecol Obstet 1957; April:390-400.
56. Shin MS, Berland LL, Ho K. Computed tomography evaluation of primary and secondary sternal neoplasms. J Comput Tomogr 1986; 10:27-32.
57. Martini N, Huvos AG, Smith J, Beattie EJ Jr. Primary malignant tumors of the sternum. Surg Gynecol Obstet 1974; 138:391-395.
58. Nigrisoli M, Ferraro A, DeCristofaro R, Picci P. Chondrosarcoma of the hand and foot. Chir Organi Mov 1990; 75:315-323.
59. Cawte TG, Steiner GC, Beltran J, Dorfman HD. Chondrosarcoma of the short tubular bones of the hands and feet. Skeletal Radiol 1998; 27: 625-632.
60. Crim JR, Mirra JM. Enchondroma protuberans. Skeletal Radiol 1990; 19:431-434.
61. Camins MB, Duncan AW, Smith J, Marcove RC. Chondrosarcoma of the spine. Spine 1978; 3:202-209.
62. Hermann G, Sacher M, Lanzieri CF, Anderson PJ, Rabinowitz JG. Chondrosarcoma of the spine: an unusual radiographic presentation. Skeletal Radiol 1985; 14:178-183.
63. Hirsh LF, Thanki A, Spector HB. Primary spinal chondrosarcoma with eighteen-year follow-up: case report and literature review. Neurosurgery 1984; 14:747-749.
64. Murphey MD, Andrews CL, Flemming DJ, Temple HT, Smith WS, Smirniotopoulos JG. Primary tumors of the spine: radiologic-pathologic correlation. RadioGraphics 1996; 16:1131-1158.
65. Shives TC, McLeod RA, Unni KK, Schray MF. Chondrosarcoma of the spine. J Bone Joint Surg Am 1989; 71:1158-1165.
66. Kothary N, Law M, Cha S, Zagzag D. Conventional and perfusion MR imaging of parafalcine chondrosarcoma. AJNR Am J Neuroradiol 2003; 24:245-248.
67. Rosenberg AE, Nielsen GP, Keel SB, et al. Chondrosarcoma of the skull base: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol 1999; 23:1370-1378.
68. Neff B, Sataloff RT, Sorey L, Hawkshaw M, Spiegel JR. Chondrosarcoma of the skull base. Laryngoscope 2002; 112:134-139.
69. Crockard HA, Cheeseman A, Steel T, et al. A multidisciplinary team approach to skull base chondrosarcomas. J Neurosurg 2001; 95:184-189.
70. Schmidinger A, Rosahl SK, Vorkapic P, Samii M. Natural history of chondroid skull base lesion: case report and review. Neuroradiology 2002; 44:268-271.
71. Huvos AG. Chondrosarcoma of the craniofacial bones. In: Mitchell J, ed. Bone tumors: diagnosis, treatment, and prognosis. 2nd ed. Philadelphia, Pa: Saunders, 1991; 395-403.
72. Unni KK, Dahlin DC, Beabout JW, Sim FH. Chondrosarcoma: clear-cell variant - a report of sixteen cases. J Bone Joint Surg Am 1976; 58: 676-683.
73. Kumar R, David R, Cierney G 3rd. Clear cell chondrosarcoma. Radiology 1985; 154:45-48.
74. Bagley L, Kneeland JB, Dalinka MK, Bullough P, Brooks J. Unusual behavior of clear-cell chondrosarcoma. Skeletal Radiol 1993; 22:279-282.
75. Kaim AH, Hugli R, Bonel HM, Jundt G. Chondroblastoma and clear-cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. Skeletal Radiol 2002; 31:88-95.
76. Present D, Bacchini P, Pignatti G, Picci P, Bertoni F, Campanacci M. Clear cell chondrosarcoma of bone: a report of 8 cases. Skeletal Radiol 1991; 20:187-191.
77. Bloem JL, Mulder JD. Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol 1985; 14:1-9.
78. Lichtenstein L. Tumors of periosteal origin. Cancer 1955; 8:1060-1069.
79. Schajowicz F. Juxtacortical chondrosarcoma. J Bone Joint Surg Br 1977; 59:473-480.
80. Nojima T, Unni KK, McLeod RA, Pritchard DJ. Periosteal chondroma and periosteal chondrosarcoma. Am J Surg Pathol 1985; 9:666-677.
81. Robinson P, White LM, Sundaram M, et al. Periosteal chondroid tumors: radiologic evaluation with pathologic correlation. AJR Am J Roentgenol 2001; 177:1183-1188.
82. Bertoni F, Boriani S, Laus M, Campanacci M. Periosteal chondrosarcoma and periosteal osteosarcoma: two distinct entities. J Bone Joint Surg Br 1982; 64:370-376.
83. Zenmyo M, Komiya S, Nakashima M, Irie K, Kakizoe M, Inoue A. Giant juxtacortical chondrosarcoma of the humerus. Orthopedics 2000; 23:497-498.
84. Kumta SM, Griffith JF, Chow LT, Leung PC. Primary juxtacortical chondrosarcoma dedifferentiating after 20 years. Skeletal Radiol 1998; 27:569-573.
85. Bauer TW, Dorfman HD, Latham JT Jr. Periosteal chondroma: a clinicopathologic study of 23 cases. Am J Surg Pathol 1982; 6:631-637.
86. Murphey MD, Robbin MR, McRae GA, Flemming DJ, Temple T, Kransdorf MJ. The many faces of osteosarcoma. RadioGraphics 1997; 17: 1205-1232.
87. Unni KK, Dahlin DC, Beabout JW. Periosteal osteogenic sarcoma. Cancer 1976; 37:2476-2485.
88. Hall RB, Robinson LH, Malawar MM, Dunham WK. Periosteal osteosarcoma. Cancer 1985; 55: 165-171.
89. Kilpatrick SE, Inwards CY, Fletcher CD, Smith MA, Gitelis S. Myxoid chondrosarcoma (chordoid sarcoma) of bone: a report of two cases and review of the literature. Cancer 1997; 79:1903-1910.
90. Steiner G, Greenspan A, Jahss M, Norman A. Myxoid chondrosarcoma of the os calcis: a case report. Foot Ankle 1984; 5:84-91.
91. Martinez-Tello FJ, Navas-Palacios JJ. Ultrastructural study of conventional chondrosarcomas and myxoid-and mesenchymal-chondrosarcomas. Virchows Arch A Pathol Anat Histol 1982; 396: 197-211.
92. Fu YS, Kay S. A comparative ultrastructural study of mesenchymal chondrosarcoma and myxoid chondrosarcoma. Cancer 1974; 33:1531-1542.
93. Gill S, McManus AP, Crew AJ, et al. Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma. Genes Chromosomes Cancer 1995; 12:307-310.
94. Sjogren H, Meis-Kindblom JM, Orndal C, et al. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma: cytogenetic, molecular genetic, and cDNA microarray analyses. Am J Pathol 2003; 162:781-792.
95. Lichtenstein L, Bernstein D. Unusual benign and malignant chondroid tumors of bone. Cancer 1959; 12:1142-1157.
96. Nakashima Y, Unni KK, Shives TC, Swee RG, Dahlin DC. Mesenchymal chondrosarcoma of bone and soft tissue: a review of 111 cases. Cancer 1986; 57:2444-2453.
97. Blackwell JB. Mesenchymal chondrosarcoma arising in fibrous dysplasia of the femur. J Clin Pathol 1993; 46:961-962.
98. Leggon RE, Munro M, Schuerch C. Thigh mass in a 52-year-old woman. Clin Orthop Rel Res 2001; 388:252-263.
99. Shapeero LG, Vanel D, Couanet D, Contesso G, Ackerman LV. Extraskeletal mesenchymal chondrosarcoma. Radiology 1993; 186:819-826.
100. Koeller KK. Mesencymal chondrosarcoma and simulating lesions of the orbit. Radiol Clin North Am 1999; 37:203-217.
101. Salvador AH, Beabout JW, Dahlin DC. Mesenchymal chondrosarcoma: observations on 30 new cases. Cancer 1971; 28:605-615.
102. Shinaver CN, Mafee MF, Choi KH. MRI of mesenchymal chondrosarcoma of the orbit: case report and review of the literature. Neuroradiol 1997; 39:296-301.
103. Ly JQ. Mesenchymal chondrosarcoma of the maxilla. AJR Am J Roentgenol 2002; 179:1077-1078.
104. Bloem JL, Reiser MF, Vanel D. Magnetic resonance contrast agents in the evaluation of the musculoskeletal system. Magn Reson Q 1990; 6:136-163.
105. Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex and location. AJR Am J Roentgenol 1995; 164:129-134.
106. Weiss SW, Goldblum JR. Cartilaginous soft tissue tumors. In: Strauss M, ed. Enzinger and Weiss's soft tissue tumors. 4th ed. St Louis, Mo: Mosby, 2001; 1368-1388.
107. Miettinen M. Cartilage and bone-forming tumors and tumor-like lesions. In: Diagnostic soft tissue pathology. Philadelphia, Pa: Churchill-Livingstone, 2003; 407-409.
108. Enzinger FM, Shiraki M. Extraskeletal myxoid chondrosarcoma: an analysis of 34 cases. Hum Pathol 1972; 3:421-435.
109. Whitten CG, El-Khoury GY, Benda JA, Ehara S. Case report 829: intramuscular myxoid chondrosarcoma. Skeletal Radiol 1994; 23:153-156.
110. Kransdorf MJ, Meis JM. Extraskeletal osseous and cartilaginous tumors of the extremities. RadioGraphics 1993; 13:853-884.
111. Meis JM, Martz KL. Extraskeletal myxoid chondrosarcoma: a clinicopathologic study of 120 cases (abstr). Lab Invest 1992; 66:9A.
112. Saleh G, Evans HL, Ro JY, Ayala AG. Extraskeletal myxoid chondrosarcoma: a clinicopathologic study often patients with long-term follow-up. Cancer 1992; 70:2827-2830.
113. Kawaguchi S, Wada T, Nagoya S, et al. Extraskeletal myxoid chondrosarcoma: a multi-institutional study of 42 cases in Japan. Cancer 2003; 97:1285-1292.
114. Goldenberg RR, Cohen P, Steinlauf P. Chondrosarcoma of the extraskeletal soft tissues. J Bone Joint Surg Am 1967; 49:1487-1507.
115. Harwood AR, Krajbich JI, Fornasier VL. Mesenchymal chondrosarcoma: a report of 17 cases. Clin Orthop Rel Res 1981; 158:144-148.
116. Chhem RK, Bui BT, Calderon-Villar H, Fontaine S. Case report: primary mesenchymal chondrosarcoma of the brain. Clin Radiol 1992; 45: 422-423.
117. Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer 1971; 28: 461-466.
118. Anract P, Tomeno B, Forest M. Dedifferentiated chondrosarcoma: a study of 13 clinical cases and review of the literature. Rev Chir Orthop Reparatrice Appar Mot 1994; 80:669-680. [French]
119. Campanacci M, Bertoni F, Capanna R. Dedifferentiated chondrosarcomas. Ital J Orthop Traumatol 1979; 5:331-341.
120. Capanna R, Bertoni F, Bettelli G, et al. Dedifferentiated chondrosarcoma. J Bone Joint Surg Am 1988; 70:60-69.
121. Daly PJ, Sim FH, Wold LE. Dedifferentiated chondrosarcoma of bone. Orthopedics 1989; 12: 763-767.
122. Frassica FJ, Unni KK, Beabout JW, et al. Dedifferentiated chondrosarcoma: a report of the clinicopathological feature and treatment of seventy-eight cases. J Bone Joint Surg Am 1986; 68: 1197-1205.
123. Mercuri M, Picci P, Campanacci L, Rulli E. Dedifferentiated chondrosarcoma. Skeletal Radiol 1995; 24:409-416.
124. Mankin HL, Cantley KP, Lippiello L, Schille AL, Campbell CJ. The biology of human chondrosarcoma. I. Description of cases, grading, and biochemical analyses. J Bone Joint Surg Am 1980; 62:160-176.
125. Mankin HL, Cantley KP, Lippiello L, Schille AL, Campbell CJ. The biology of human chondrosarcoma. II. Variation in chemical composition among types and subtypes of benign and malignant cartilage tumors. J Bone Joint Surg Am 1980; 62:176-188.
126. Schreuder HW, Keijser LC, Veth RP. Beneficial effects of cryosurgery treatment in benign and low-grade-malignant bone tumors in 120 patients. Ned Tijdschr Geneeskd 1999; 143:2275-2281. [Dutch]
127. Schreuder HW, Prusczynski M, Veth RP, Lemmens JA. Treament of benign and low-grade malignant intramedullary chondroid tumours with curettage and cryosurgery. Eur J Surg Oncol 1998; 24:120-126.
128. Sheth DS, Yasko AW, Johnson ME, Ayala AG, Murray JA, Romsdahl MM. Chondrosarcoma of the pelvis: prognostic factors for 67 patients treated with definitive surgery. Cancer 1996; 78: 745-750.
129. Springfield DS, Gebhardt MC, McGuire MH. Chondrosarcoma: a review. J Bone Joint Surg Am 1996; 78:141-149.
130. Gitelis S, Bertoni F, Picci CP, Campanacci M. Chondrosarcoma of bone. J Bone Joint Surg Am 1981; 63:1248-1256.
131. Mitchell A, Rudan JR, Fenton PV. Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. Mod Pathol 1996; 9:279-283.
132. Mitchell AD, Ayoub K, Mangham DC, Grimer RJ, Carter SR, Tillman RM. Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br 2000; 82:55-61.
133. Harwood AR, Krajbich JI, Fornasier VL. Radiotherapy of chondrosarcoma of bone. Cancer 1980; 45:2769-2777.
134. Multhaupt HA, Alvarez JC, Rafferty PA, Warhol MJ, Lackman RD. Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas: in vitro and in vivo correlation. J Bone Joint Surg Am 2001; 83:56-61.