Analysis of the expression of the notch3 receptor protein in adult lung cancer

Oncology Letters

Volumn 5, Issue 2, 2013, Pages 499-504

  Zhou, Min ^a   Jin, Wei Yun ^a   Fan, Zhi Wen ^b   Han, Rui Chao ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b School of Medicine   (China)

Author keywords

Bronchiogenic carcinoma; Lung cancer; Notch3

Indexed keywords

MESSENGER RNA; NOTCH3 RECEPTOR;

ADULT; AGED; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84871539859     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.1033     Document Type: Article

References (23)

1. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
2. Tonon G, Modi S, Wu L, et al: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33: 208-213, 2003.
3. Collins BJ, Kleeberger W and Ball DW: Notch in lung development and lung cancer. Semin Cancer Biol 14: 357-364, 2004.
4. Lin L, Mernaugh R, Yi F, Blum D, Carbone DP and Dang TP: Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. Cancer Res 70: 632-638, 2010.
5. Westhoff B, Colaluca IN, D'Ario G, et al: Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci USA 106: 22293-22298, 2009.
6. Baumgart A, Seidl S, Vlachou P, et al: ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. Cancer Res 70: 5368-5378, 2010.
7. Fan JY, Wang YF, Han B, Ji YR, Song HD and Fan XQ: FOXL2 mutations in Chinese families with Blepharophimosis syndrome (BPES). Transl Res 157: 48-52, 2011.
8. Katoh M: Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int J Oncol 31: 461-466, 2007.
9. Katoh M: Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int J Mol Med 17: 681-685, 2006.
10. Zou YH, Cao YQ, Wang LX, Zhang YH, Yue ZJ and LiuJM: γ-secretase inhibitor up-regulates vascular endothelial growth factor receptor-2 and endothelial nitric oxide synthase. Exp Ther Med 2: 725-729, 2011.
11. Benedito R, Rocha SF, Woeste M, et al: Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 484: 110-114, 2012.
12. Ansel KM, Djuretic I, Tanasa B and Rao A: Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol24: 607-656, 2006.
13. Ellisen LW, Bird J, West DC, et al: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661, 1991.
14. Purow BW, Haque RM, Noel MW, et al: Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 65: 2353-2363, 2005.
15. Wu F, Stutzman A and Mo YY: Notch signaling and its role in breast cancer. Front Biosci 12: 4370-4383, 2007.
16. Güngör C, Zander H, Effenberger KE, et al: Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. Cancer Res 71: 5009-5019, 2011.
17. Ye QF, Zhang YC, Peng XQ, Long Z, Ming YZ and He LY: Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax. Oncol Lett 3: 879-884, 2012.
18. Ito T, Udaka N, Ikeda M, Yazawa T, Kageyama R and KitamuraH: Significance of proneural basic helix-loop-helix transcription factors in neuroendocrine differentiation of fetal lung epithelial cells and lung carcinoma cells. Histol Histopathol 16: 335-343, 2001.
19. Eliasz S, Liang S, Chen Y, et al: Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene 29: 2488-2498, 2010.
20. Sriuranpong V, Borges MW, Ravi RK, et al: Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 61: 3200-3205, 2001.
21. Zhou M, Ma J and Guo X: The analysis of Notch1 receptor protein expression in adult SCLC and NSCLDC. J Clin Res (Chinese) 27: 398-400, 2010.
22. Fan Z, Zhou M and M: Express of Notch1 protein in adult adenocarcinoma of lung and its significance. Int J Respir (Chinese) 31: 1625-1628, 2011.
23. Guo XJ, Zhou M, Ren LP, Yang M, Huang SG and Xu WG: Small interfering RNA-mediated knockdown of Notch1 in lung. Chin Med J (Engl) 122: 2647-2651, 2009.