22: 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis

British Journal of Nutrition

Volumn 108, Issue 12, 2012, Pages 2129-2137

  Bianchini, Francesca ^a   Giannoni, Elisa ^a   Serni, Sergio ^a   Chiarugi, Paola ^a,b   Calorini, Lido ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b ISTITUTO TOSCANO TUMORI   (Italy)

Author keywords

22 : 6n 3 DHA; Epithelial mesenchymal transition; Intratumoral myofibroblast differentiation; Prostate cancers

Indexed keywords

22:6N 3 DOCOSAHEXAENOIC ACID; ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; GELATINASE A; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACTA2 PROTEIN, HUMAN; ACTIN; OMEGA 3 FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MIGRATION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PROSTATE ADENOCARCINOMA; PROSTATE FIBROBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR MICROENVIRONMENT; ADENOCARCINOMA; ANIMAL; CELL TRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; MOUSE MUTANT; PATHOLOGY; PROSTATE; PROSTATE TUMOR; TUMOR CELL LINE;

ANIMALIA;

ACTINS; ADENOCARCINOMA; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DOCOSAHEXAENOIC ACIDS; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY ACIDS, OMEGA-3; FIBROBLASTS; HUMANS; MALE; MICE; MICE, SCID; MYOFIBROBLASTS; PROSTATE; PROSTATIC NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871537351     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512000359     Document Type: Article

References (31)

1. Witz IP (2008) Tumor-microenvironment interactions: dangerous liaisons. Adv Cancer Res 100, 203-229. (Pubitemid 351932184)
2. Kalluri R & Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6, 392-401.
3. Coussens LM & Werb Z (2002) Inflammation and cancer. Nature 420, 860-867. (Pubitemid 36019639)
4. Calorini L & Bianchini F (2010) Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal 7, 24-34.
5. Orimo A, Gupta PB, Sgroi DC, et al. (2005) Stromal fibro-blasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348. (Pubitemid 40692295)
6. Erez N, Truitt M, Olson P, et al. (2010) Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 17, 135-147.
7. Allinen M, Beroukhim R, Cai L, et al. (2004) Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6, 17-32. (Pubitemid 38903159)
8. Hill R, Song Y, Cardiff RD, et al. (2005) Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 16, 1001-1011. (Pubitemid 41785416)
9. Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 25, 1650-1659. (Pubitemid 17052899)
10. Hinz B, Phan SH, Thannickal VJ, et al. (2007) The myo-fibroblast: one function, multiple origins. Am J Pathol 170, 1807-1816. (Pubitemid 47339255)
11. Giannoni E, Bianchini F, Masieri L, et al. (2010) Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 70, 6945-6956.
12. Sugimoto H, Mundel TM, Kieran MW, et al. (2006) Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther 5, 1640-1646.
13. Chung LW, Baseman A, Assikis V, et al. (2005) Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. J Urol 173, 10-20. (Pubitemid 39627663)
14. Olumi AF, Grossfeld GD, Hayward SW, et al. (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59, 5002-5011. (Pubitemid 29472907)
15. Verona EV, Elkahloun AG, Yang J, et al. (2007) Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling. Cancer Res 15, 5737-5746. (Pubitemid 46985006)
16. De Wever O & Mareel M (2003) Role of tissue stroma in cancer cell invasion. J Pathol 200, 429-447. (Pubitemid 36818244)
17. Chavarro JE, Stampfer MJ, Li H, et al. (2007) A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 16, 1364-1370. (Pubitemid 47076865)
18. Neuhouser ML, Barnett MJ, Kristal AR, et al. (2007) (n-6) PUFA increase and dairy foods decrease prostate cancer risk in heavy smokers. J Nutr 137, 1821-1827. (Pubitemid 47037713)
19. Reddy BD (2004) Omega-3 fatty acids in colorectal cancer prevention. Int J Cancer 112, 1-7.
20. Xia S, Lu Y, Wang J, et al. (2006) Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci U S A 103, 12499-12504. (Pubitemid 44267287)
21. Berquin IM, Edwards IJ & Chen YQ (2008) Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett 269, 363-377.
22. McEntee MF, Ziegler C, Reel D, et al. (2008) Dietary n-3 poly-unsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. Am J Pathol 173, 229-241. (Pubitemid 351947970)
23. Rose DP & Connolly JM (1999) Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83, 217-244. (Pubitemid 29430123)
24. Mannini A, Kerstin N, Calorini L, et al. (2009) An enhanced apoptosis and a reduced angiogenesis are associated with the inhibition of lung colonisation in animals fed an n-3 polyunsaturated fatty acid-rich diet injected with a highly metastatic murine melanoma line. Br J Nutr 101, 688-693.
25. Reich R, Royce L & Martin GR (1989) Eicosapentaenoic acid reduces the invasive and metastatic activities of malignant tumor cells. Biochem Biophys Res Commun 160, 559-564. (Pubitemid 19140578)
26. Chen TR (1977) In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp Cell Res 104, 255-262. (Pubitemid 8047559)
27. Rahman MM, Bhattacharya A & Fernandes G (2008) Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. J Cell Physiol 214, 201-209. (Pubitemid 350225482)
28. Narayanan BA, Narayanan NK, Simi B, et al. (2003) Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosa-hexaenoic acid in human colon cancer cells. Cancer Res 63, 972-979. (Pubitemid 36278427)
29. Matsumoto K & Nakamura T (2006) Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int J Cancer 119, 477-483. (Pubitemid 43955698)
30. Cat B, Stuhlmann D, Steinbrenner H, et al. (2006) Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J Cell Sci 119, 2727-2738. (Pubitemid 44184009)
31. Arab K, Rossary A, Flourié F, et al. (2006) Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and gluta-thione reductase. Br J Nutr 95, 18-26. (Pubitemid 43250708)