YB-1 Synthesis Is Regulated by mTOR Signaling Pathway

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Lyabin, Dmitry N ^a   Eliseeva, Irina A ^a   Ovchinnikov, Lev P ^a  

^a INSTITUTE OF PROTEIN RESEARCH   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; RNA; Y BOX BINDING PROTEIN 1;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL DIVISION; EUKARYOTIC CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RABBIT; RNA TRANSLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL DIVISION; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INDOLES; MICE; ORGAN SPECIFICITY; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PURINES; RABBITS; RIBONUCLEOPROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; Y-BOX-BINDING PROTEIN 1;

EUKARYOTA; ORYCTOLAGUS CUNICULUS;

EID: 84871446664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052527     Document Type: Article

References (44)

1. Eliseeva IA, Kim ER, Guryanov SG, Ovchinnikov LP, Lyabin DN, (2011) Y-box-binding protein 1 (YB-1) and its functions. Biochemistry (Mosc) 76: 1402-1433.
2. Skabkin MA, Evdokimova V, Thomas AA, Ovchinnikov LP, (2001) The major messenger ribonucleoprotein particle protein p50 (YB-1) promotes nucleic acid strand annealing. J Biol Chem 276: 44841-44847.
3. Gaudreault I, Guay D, Lebel M, (2004) YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. Nucleic Acids Res 32: 316-327.
4. Levenson VV, Davidovich IA, Roninson IB, (2000) Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res 60: 5027-5030.
5. Pestryakov P, Zharkov DO, Grin I, Fomina EE, Kim ER, et al. (2012) Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1. J Mol Recognit 25: 224-233.
6. Chansky HA, Hu M, Hickstein DD, Yang L, (2001) Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein. Cancer Res 61: 3586-3590.
7. Raffetseder U, Frye B, Rauen T, Jurchott K, Royer HD, et al. (2003) Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. J Biol Chem 278: 18241-18248.
8. Evdokimova V, Ruzanov P, Anglesio MS, Sorokin AV, Ovchinnikov LP, et al. (2006) Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol 26: 277-292.
9. Evdokimova V, Ruzanov P, Imataka H, Raught B, Svitkin Y, et al. (2001) The major mRNA-associated protein YB-1 is a potent 5′ cap-dependent mRNA stabilizer. EMBO J 20: 5491-5502.
10. Nekrasov MP, Ivshina MP, Chernov KG, Kovrigina EA, Evdokimova VM, et al. (2003) The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage. J Biol Chem 278: 13936-13943.
11. Svitkin YV, Evdokimova VM, Brasey A, Pestova TV, Fantus D, et al. (2009) General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J 28: 58-68.
12. Kuwano M, Oda Y, Izumi H, Yang SJ, Uchiumi T, et al. (2004) The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. Mol Cancer Ther 3: 1485-1492.
13. Knosel T, Emde A, Schluns K, Chen Y, Jurchott K, et al. (2005) Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. Neoplasia 7: 741-747.
14. Stein U, Jurchott K, Walther W, Bergmann S, Schlag PM, et al. (2001) Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. J Biol Chem 276: 28562-28569.
15. Ohga T, Koike K, Ono M, Makino Y, Itagaki Y, et al. (1996) Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light. Cancer Res 56: 4224-4228.
16. Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, et al. (1997) Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med 3: 447-450.
17. Bader AG, Vogt PK, (2005) Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation. Mol Cell Biol 25: 2095-2106.
18. Evdokimova V, Tognon C, Ng T, Ruzanov P, Melnyk N, et al. (2009) Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell 15: 402-415.
19. Gens GP, Moiseeva NI, Stromskaia TP, Rybalkina E, Vaiman AV, et al. (2010) [Determination of the amount of YB-1 gene mRNA in the breast tumor tissues to predict the course of disease]. Klin Lab Diagn: 29-32.
20. Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR, (2010) YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Biochem Biophys Res Commun 398: 482-488.
21. Wu Y, Yamada S, Izumi H, Li Z, Shimajiri S, et al. (2012) Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer. J Surg Oncol 105: 724-730.
22. Frye BC, Halfter S, Djudjaj S, Muehlenberg P, Weber S, et al. (2009) Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. EMBO Rep 10: 783-789.
23. Rauen T, Raffetseder U, Frye BC, Djudjaj S, Muhlenberg PJ, et al. (2009) YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem 284: 26928-26940.
24. Uramoto H, Izumi H, Ise T, Tada M, Uchiumi T, et al. (2002) p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression. J Biol Chem 277: 31694-31702.
25. Shiota M, Izumi H, Onitsuka T, Miyamoto N, Kashiwagi E, et al. (2008) Twist promotes tumor cell growth through YB-1 expression. Cancer Res 68: 98-105.
26. Shiota M, Izumi H, Tanimoto A, Takahashi M, Miyamoto N, et al. (2009) Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth. Cancer Res 69: 3148-3156.
27. Yokoyama H, Harigae H, Takahashi S, Furuyama K, Kaku M, et al. (2003) Regulation of YB-1 gene expression by GATA transcription factors. Biochem Biophys Res Commun 303: 140-145.
28. Ohashi S, Fukumura R, Higuchi T, Kobayashi S, (2009) YB-1 transcription in the postnatal brain is regulated by a bHLH transcription factor Math2 through an E-box sequence in the 5′-UTR of the gene. Mol Cell Biochem 327: 267-275.
29. Lyabin DN, Eliseeva IA, Skabkina OV, Ovchinnikov LP (2011) Interplay between Y-box-binding protein 1 (YB-1) and poly(A) binding protein (PABP) in specific regulation of YB-1 mRNA translation. RNA Biol 8.
30. Skabkina OV, Lyabin DN, Skabkin MA, Ovchinnikov LP, (2005) YB-1 autoregulates translation of its own mRNA at or prior to the step of 40S ribosomal subunit joining. Mol Cell Biol 25: 3317-3323.
31. Skabkina OV, Skabkin MA, Popova NV, Lyabin DN, Penalva LO, et al. (2003) Poly(A)-binding protein positively affects YB-1 mRNA translation through specific interaction with YB-1 mRNA. J Biol Chem 278: 18191-18198.
32. Kato M, Wang L, Putta S, Wang M, Yuan H, et al. (2010) Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. J Biol Chem 285: 34004-34015.
33. Feng Q, Huang S, Zhang A, Chen Q, Guo X, et al. (2009) Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2. Nephron Exp Nephrol 113: e16-25.
34. Bergmann S, Royer-Pokora B, Fietze E, Jurchott K, Hildebrandt B, et al. (2005) YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification. Cancer Res 65: 4078-4087.
35. Basaki Y, Taguchi K, Izumi H, Murakami Y, Kubo T, et al. (2010) Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells. Eur J Cancer 46: 954-965.
36. Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
37. Ma XM, Blenis J, (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318.
38. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, et al. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485: 55-61.
39. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7: e38.
40. Bianchini A, Loiarro M, Bielli P, Busa R, Paronetto MP, et al. (2008) Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis 29: 2279-2288.
41. Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, et al. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485: 109-113.
42. Wakiyama M, Futami T, Miura K, (1997) Poly(A) dependent translation in rabbit reticulocyte lysate. Biochimie 79: 781-785.
43. Dmitriev SE, Andreev DE, Terenin IM, Olovnikov IA, Prassolov VS, et al. (2007) Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5′ untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated. Mol Cell Biol 27: 4685-4697.
44. Pokrovskaya ID, Gurevich VV, (1994) In vitro transcription: preparative RNA yields in analytical scale reactions. Anal Biochem 220: 420-423.