G-Protein Coupled Receptor 30 (GPR30): A Novel Regulator of Endothelial Inflammation

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Chakrabarti, Subhadeep ^a,b   Davidge, Sandra T ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MAZANKOWSKI ALBERTA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; ESTROGEN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR 30; INTERCELLULAR ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIITIS; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ANTI-INFLAMMATORY AGENTS; CELL NUCLEUS; CYCLOPENTANES; ENDOTHELIUM, VASCULAR; ESTRADIOL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; NF-KAPPA B; QUINOLINES; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; TAMOXIFEN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84871426922     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052357     Document Type: Article

References (61)

1. Regitz-Zagrosek V, (2006) Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 5: 425-38.
2. Stork S, van der Schouw YT, Grobbee DE, Bots ML, (2004) Estrogen, inflammation and cardiovascular risk in women: a critical appraisal. Trends Endocrinol Metab 15: 66-72.
3. Arnal JF, Scarabin PY, Tremollieres F, Laurell H, Gourdy P, (2007) Estrogens in vascular biology and disease: where do we stand today? Curr Opin Lipidol 18: 554-60.
4. Qiao X, McConnell KR, Khalil RA (2008) Sex steroids and vascular responses in hypertension and aging. Gend Med 5 Suppl A: S46-64.
5. Ihionkhan CE, Chambliss KL, Gibson LL, Hahner LD, Mendelsohn ME, et al. (2002) Estrogen causes dynamic alterations in endothelial estrogen receptor expression. Circ Res 91: 814-20.
6. Ba ZF, Chaudry IH, (2008) Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage. Am J Physiol Heart Circ Physiol 295: H2061-7.
7. Filardo EJ, Thomas P, (2005) GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol Metab 16: 362-7.
8. Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ, (1997) Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 45: 607-17.
9. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER, (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307: 1625-30.
10. Filardo EJ, Thomas P, (2012) Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology. Endocrinology 153: 2953-62.
11. Barton M, (2012) Position paper: The membrane estrogen receptor GPER- Clues and questions. Steroids 77: 935-42.
12. Nilsson BO, Olde B, Leeb-Lundberg LM, (2011) G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling. Br J Pharmacol 163: 1131-9.
13. Broughton BR, Miller AA, Sobey CG, (2010) Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol 298: H1055-61.
14. Seok YM, Jang EJ, Reiser O, Hager M, Kim IK (2012) 17beta-Estradiol induces vasorelaxation in a G-protein-coupled receptor 30-independent manner. Naunyn Schmiedebergs Arch Pharmacol.
15. Yates MA, Li Y, Chlebeck PJ, Offner H, (2010) GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol 11: 20.
16. Zhang B, Subramanian S, Dziennis S, Jia J, Uchida M, et al. (2010) Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke. J Immunol 184: 4087-94.
17. Blasko E, Haskell CA, Leung S, Gualtieri G, Halks-Miller M, et al. (2009) Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol 214: 67-77.
18. Weil BR, Manukyan MC, Herrmann JL, Wang Y, Abarbanell AM, et al. (2010) Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury. Surgery 148: 436-43.
19. Rowlands DJ, Chapple S, Siow RC, Mann GE, (2011) Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. Hypertension 57: 833-40.
20. Holm A, Baldetorp B, Olde B, Leeb-Lundberg LM, Nilsson BO, (2011) The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle. J Vasc Res 48: 327-35.
21. Sanchez AM, Flamini MI, Zullino S, Gopal S, Genazzani AR, et al. (2011) Estrogen receptor-{alpha} promotes endothelial cell motility through focal adhesion kinase. Mol Hum Reprod 17: 219-26.
22. Chakrabarti S, Chan CK, Jiang Y, Davidge ST, (2012) Neuronal nitric oxide synthase regulates endothelial inflammation. J Leukoc Biol 91: 947-56.
23. Sankaralingam S, Xu Y, Sawamura T, Davidge ST, (2009) Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite. Hypertension 53: 270-7.
24. Merchant SJ, Narumiya H, Zhang Y, Guilbert LJ, Davidge ST, (2004) The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2. Hypertens Pregnancy 23: 47-60.
25. Arenas IA, Xu Y, Lopez-Jaramillo P, Davidge ST, (2004) Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha. Am J Physiol Cell Physiol 286: C779-84.
26. Narumiya H, Zhang Y, Fernandez-Patron C, Guilbert LJ, Davidge ST, (2001) Matrix metalloproteinase-2 is elevated in the plasma of women with preeclampsia. Hypertens Pregnancy 20: 185-94.
27. Chakrabarti S, Davidge ST (2009) High glucose-induced oxidative stress alters estrogen effects on ERalpha and ERbeta in human endothelial cells: Reversal by AMPK activator. J Steroid Biochem Mol Biol.
28. Madeo A, Maggiolini M, (2010) Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Cancer Res 70: 6036-46.
29. Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF, (2007) The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 48: 751-62.
30. Korpelainen EI, Gamble JR, Smith WB, Goodall GJ, Qiyu S, et al. (1993) The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration. Proc Natl Acad Sci U S A 90: 11137-41.
31. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, et al. (2005) ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood 106: 584-92.
32. Wollin M, Abele S, Bruns H, Weyand M, Kalden JR, et al. (2009) Inhibition of TNF-alpha reduces transplant arteriosclerosis in a murine aortic transplant model. Transpl Int 22: 342-9.
33. Zhou Z, Connell MC, MacEwan DJ, (2007) TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal 19: 1238-48.
34. Huang NL, Chiang SH, Hsueh CH, Liang YJ, Chen YJ, et al. (2009) Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Int J Cardiol 134: 169-75.
35. Thomas P, Pang Y, Filardo EJ, Dong J, (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146: 624-32.
36. Balhuizen A, Kumar R, Amisten S, Lundquist I, Salehi A, (2010) Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol Cell Endocrinol 320: 16-24.
37. Li ZL, Liu JC, Liu SB, Li XQ, Yi DH, et al. (2012) Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus. PLoS One 7: e38787.
38. Gonzalez-Gay MA, Garcia-Unzueta MT, De Matias JM, Gonzalez-Juanatey C, Garcia-Porrua C, et al. (2006) Influence of anti-TNF-alpha infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis. Clin Exp Rheumatol 24: 373-9.
39. Taylor PC, Peters AM, Paleolog E, Chapman PT, Elliott MJ, et al. (2000) Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum 43: 38-47.
40. Blankenberg S, Barbaux S, Tiret L, (2003) Adhesion molecules and atherosclerosis. Atherosclerosis 170: 191-203.
41. Foster CA, (1996) VCAM-1/alpha 4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. J Allergy Clin Immunol 98: S270-7.
42. Rahman A, Fazal F (2008) Hug Tightly and Say Goodbye: Role of Endothelial ICAM-1 in Leukocyte Transmigration. Antioxid Redox Signal.
43. Chakrabarti S, Davidge ST, (2012) Estradiol Modulates Tumor Necrosis Factor-Induced Endothelial Inflammation: Role of Tumor Necrosis Factor Receptor 2. J Vasc Res 50: 21-34.
44. Hinojosa-Laborde C, Craig T, Zheng W, Ji H, Haywood JR, et al. (2004) Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension 44: 405-9.
45. Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, et al. (2001) Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 103: 423-8.
46. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, et al. (2002) Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res 90: 1087-92.
47. Dean SA, Tan J, O'Brien ER, Leenen FH, (2005) 17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats. Am J Physiol Regul Integr Comp Physiol 288: R759-66.
48. Mori M, Tsukahara F, Yoshioka T, Irie K, Ohta H, (2004) Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors. Life Sci 75: 599-609.
49. Zhang X, Wang LY, Jiang TY, Zhang HP, Dou Y, et al. (2002) Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways. Life Sci 71: 15-29.
50. Zhang X, Wang L, Dou Y, Zhao J, Jiang T, et al. (2002) Testosterone and estradiol modulate TNF-alpha-induced expression of adhesion molecules in endothelial cells. Methods Find Exp Clin Pharmacol 24: 125-30.
51. Aziz KE, Wakefield D, (1996) Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone. Cell Immunol 167: 79-85.
52. Florian M, Magder S, (2008) Estrogen decreases TNF-alpha and oxidized LDL induced apoptosis in endothelial cells. Steroids 73: 47-58.
53. Mukherjee TK, Reynolds PR, Hoidal JR, (2005) Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta 1745: 300-9.
54. Coma M, Guix FX, Uribesalgo I, Espuna G, Sole M, et al. (2005) Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain 128: 1613-21.
55. Sherwood A, Bower JK, McFetridge-Durdle J, Blumenthal JA, Newby LK, et al. (2007) Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. Arterioscler Thromb Vasc Biol 27: 1782-7.
56. Miller AP, Xing D, Feng W, Fintel M, Chen YF, et al. (2007) Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries. Menopause 14: 251-60.
57. Ajayi AA, Ogungbade GO, Okorodudu AO, (2004) Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: studies in gonadectomized and sham-operated Zucker diabetic rats. Eur J Clin Invest 34: 349-57.
58. Somjen D, Paller CJ, Gayer B, Kohen F, Knoll E, et al. (2004) High glucose blocks the effects of estradiol on human vascular cell growth: differential interaction with estradiol and raloxifene. J Steroid Biochem Mol Biol 88: 101-10.
59. Chakrabarti S, Lekontseva O, Peters A, Davidge ST, (2010) 17beta-Estradiol induces protein S-nitrosylation in the endothelium. Cardiovasc Res 85: 796-805.
60. Ding Q, Gros R, Limbird LE, Chorazyczewski J, Feldman RD, (2009) Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. Am J Physiol Cell Physiol 297: C1178-87.
61. Gao F, Ma X, Ostmann AB, Das SK, (2011) GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERalpha) phosphorylation signals. Endocrinology 152: 1434-47.