Flavonoid myricetin modulates GABAA receptor activity through activation of Ca2+ channels and CaMK-II pathway

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Zhang, Xiao Hu ^a   Ma, Ze Gang ^b   Rowlands, Dewi Kenneth ^a   Gou, Yu Lin ^a   Fok, Kin Lam ^a   Wong, Hau Yan ^a   Yu, Mei Kuen ^a   Tsang, Lai Ling ^a   Mu, Li ^c   Chen, Lei ^b   Yung, Wing Ho ^d   Chung, Yiu Wa ^a   Zhang, Bei Lin ^c   Zhao, Hua ^c   Chan, Hsiao Chang ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b QINGDAO UNIVERSITY   (China)

^c JILIN UNIVERSITY   (China)

^d and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL; FLUMAZENIL; MYRICETIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CONTROLLED STUDY; GABAERGIC SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOFLUORESCENCE; MALE; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

EID: 84871417728     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/758097     Document Type: Article

References (46)

1. Watanabe M., Maemura K., Kanbara K., Tamayama T., Hayasaki H., Kwang W. J., GABA and GABA receptors in the central nervous system and other organs. International Review of Cytology A Survey of Cell Biology. Volume 213 2002 New York, NY, USA Academic Press 1 47 (Pubitemid 34121040)
2. Gottesmann C., GABA mechanisms and sleep. Neuroscience 2002 111 2 231 239 2-s2.0-0037052652 10.1016/S0306-4522(02)00034-9 (Pubitemid 34442609)
3. Möhler H., GABA A receptor diversity and pharmacology. Cell and Tissue Research 2006 326 2 505 516 2-s2.0-33748925413 10.1007/s00441-006-0284-3 (Pubitemid 44435822)
4. Szabadi E., Drugs for sleep disorders: mechanisms and therapeutic prospects. British Journal of Clinical Pharmacology 2006 61 6 761 766 2-s2.0-33646924810 10.1111/j.1365-2125.2006.02680.x (Pubitemid 43794807)
5. Jones B. E., From waking to sleeping: neuronal and chemical substrates. Trends in Pharmacological Sciences 2005 26 11 578 586 2-s2.0-27144454353 10.1016/j.tips.2005.09.009 (Pubitemid 41505226)
6. McCarley R. W., Neurobiology of REM and NREM sleep. Sleep Medicine 2007 8 4 302 330 2-s2.0-34248201151 10.1016/j.sleep.2007.03.005 (Pubitemid 46706357)
7. Richey S. M., Krystal A. D., Pharmacological advances in the treatment of insomnia. Current Pharmaceutical Design 2011 17 15 1471 1475 10.2174/138161211796197052
8. Saddichha S., Diagnosis and treatment of chronic insomnia. Annals of Indian Academy of Neurology 2010 13 2 94 102 2-s2.0-77954222302 10.4103/0972-2327.64628
9. Seibt J., Aton S. J., Jha S. K., Coleman T., Dumoulin M. C., Frank M. G., The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity. Sleep 2008 31 10 1381 1391 2-s2.0-54349126474
10. Hajak G., Müller W. E., Wittchen H. U., Pittrow D., Kirch W., Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction 2003 98 10 1371 1378 2-s2.0-0142029653 10.1046/j.1360-0443.2003.00491.x (Pubitemid 37297243)
11. Harborne J. B., Williams C. A., Advances in flavonoid research since 1992. Phytochemistry 2000 55 6 481 504 2-s2.0-0034736046 10.1016/S0031-9422(00) 00235-1
12. Wang F., Huen M. S. Y., Tsang S. Y., Xue H., Neuroactive flavonoids interacting with GABAA receptor complex. Current Drug Targets 2005 4 5 575 585 2-s2.0-26844489782 10.2174/156800705774322030 (Pubitemid 41448383)
13. Griebel G., Perrault G., Tan S., Schoemaker H., Sanger D. J., Pharmacological studies on synthetic flavonoids: comparison with diazepam. Neuropharmacology 1999 38 7 965 977 2-s2.0-0033008340 10.1016/S0028-3908(99) 00026-X (Pubitemid 29240613)
14. Ong K. C., Khoo H. E., Biological effects of myricetin. General Pharmacology 1997 29 2 121 126 2-s2.0-0030747399 10.1016/S0306-3623(96)00421-1 (Pubitemid 27312361)
15. Liu I. M., Tzeng T. F., Liou S. S., Lan T. W., Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Medica 2007 73 10 1054 1060 2-s2.0-34548614885 10.1055/s-2007-981577 (Pubitemid 47401289)
16. Nirmala P., Ramanathan M., Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis. Journal of Experimental Therapeutics and Oncology 2011 9 2 101 108 2-s2.0-79959224038
17. Ma Z. G., Wang J., Jiang H., Liu T. W., Xie J. X., Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats. NeuroReport 2007 18 11 1181 1185 2-s2.0-34250888826 10.1097/WNR.0b013e32821c51fe (Pubitemid 46988076)
18. Schwarz D., Kisselev P., Schunck W. H., Roots I., Inhibition of 17 β -estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. Biochimica et Biophysica Acta 2011 1814 1 168 174 2-s2.0-78649446078 10.1016/j.bbapap.2010.09.014
19. Meotti F. C., Luiz A. P., Pizzolatti M. G., Kassuya C. A. L., Calixto J. B., Santos A. R. S., Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. Journal of Pharmacology and Experimental Therapeutics 2006 316 2 789 796 2-s2.0-31144471480 10.1124/jpet.105.092825 (Pubitemid 43131007)
20. 2+ channels. European Journal of Pharmacology 2007 567 3 198 205 2-s2.0-34250845861 10.1016/j.ejphar.2007.03. 039 (Pubitemid 46976890)
21. 2+ channels. European Journal of Pain 2010 14 10 992 998 2-s2.0-78349305945 10.1016/j.ejpain.2010.04.005
22. Mignot E., Taheri S., Nishino S., Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nature Neuroscience 2002 5 1071 1075 2-s2.0-0036828979 10.1038/nn944 (Pubitemid 35247202)
23. Szymusiak R., Gvilia I., McGinty D., Hypothalamic control of sleep. Sleep Medicine 2007 8 4 291 301 2-s2.0-34248206205 10.1016/j.sleep.2007.03.013 (Pubitemid 46706353)
24. Saper C. B., Scammell T. E., Lu J., Hypothalamic regulation of sleep and circadian rhythms. Nature 2005 437 7063 1257 1263 2-s2.0-27644457084 10.1038/nature04284 (Pubitemid 41568665)
25. Herman J. P., Tasker J. G., Ziegler D. R., Cullinan W. E., Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections. Pharmacology Biochemistry and Behavior 2002 71 3 457 468 2-s2.0-0036159865 10.1016/S0091-3057(01)00681-5 (Pubitemid 34117714)
26. Winsky-Sommerer R., Yamanaka A., Diano S., Borok E., Roberts A. J., Sakurai T., Kilduff T. S., Horvath T. L., De Lecea L., Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. Journal of Neuroscience 2004 24 50 11439 11448 2-s2.0-10644267749 10.1523/JNEUROSCI.3459-04.2004 (Pubitemid 39658279)
27. Winsky-Sommerer R., Boutrel B., de Lecea L., Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry. Molecular Neurobiology 2005 32 3 285 294 2-s2.0-29744457095 10.1385/MN:32:3:285 (Pubitemid 43024033)
28. Vgontzas A. N., Chrousos G. P., Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinology and Metabolism Clinics of North America 2002 31 1 15 36 2-s2.0-0036014490 10.1016/S0889-8529(01)00005-6 (Pubitemid 34578612)
29. Vijayan R. S., Bhattacharyya D., Ghoshal N., Deciphering the binding mode of Zolpidem to GABA(A) alpha (1) receptor-insights from molecular dynamics simulation. Journal of Molecular Modeling 2012 18 4 1345 1354 10.1007/s00894-011-1142-0
30. Chen L., Chan C. S., Yung W. H., Electrophysiological and behavioral effects of zolpidem in rat globus pallidus. Experimental Neurology 2004 186 2 212 220 2-s2.0-1542616963 10.1016/j.expneurol.2003.11.003 (Pubitemid 38333194)
31. 2+/calmodulin type II-dependent protein kinase. Neuropharmacology 1997 36 10 1377 1385 2-s2.0-0030773614 10.1016/S0028-3908(97) 00111-1 (Pubitemid 27502195)
32. 2+/calmodulin protein kinase II α (CaMKII α) to inhibitory synapses. Proceedings of the National Academy of Sciences of the United States of America 2010 107 47 20559 20564 2-s2.0-78650577766 10.1073/pnas.1010346107
33. Houston C. M., He Q., Smart T. G., CaMKII phosphorylation of the GABAA receptor: receptor subtype- and synapse-specific modulation. Journal of Physiology 2009 587 10 2115 2125 2-s2.0-65749099606 10.1113/jphysiol.2009.171603
34. Houston C. M., Lee H. H. C., Hosie A. M., Moss S. J., Smart T. G., Identification of the sites for CaMK-II-dependent phosphorylation of GABAA receptors. Journal of Biological Chemistry 2007 282 24 17855 17865 2-s2.0-34547114252 10.1074/jbc.M611533200 (Pubitemid 47100330)
35. 2+/calmodulin-dependent protein kinase II. Journal of Biological Chemistry 1990 265 8 4315 4320 2-s2.0-0025259442
36. 2+/calmodulin-dependent kinase II. Proceedings of the National Academy of Sciences of the United States of America 1996 93 23 13351 13356 2-s2.0-0029801108
37. Mizoguchi Y., Ishibashi H., Nabekura J., The action of BDNF on GABAA currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. Journal of Physiology 2003 548 3 703 709 2-s2.0-0038662967 10.1113/jphysiol.2003.038935 (Pubitemid 36592766)
38. 2+ channels activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn-Schmiedeberg's Archives of Pharmacology 2003 368 6 470 478 2-s2.0-0347361480 10.1007/s00210-003-0836-y (Pubitemid 38041310)
39. 2+ current. Journal of Pharmacology and Experimental Therapeutics 2005 313 2 790 797 2-s2.0-18044362137 10.1124/jpet.104.080135 (Pubitemid 40604180)
40. Skelding K. A., Rostas J. A. P., Regulation of CaMKII in vivo: the importance of targeting and the intracellular microenvironment. Neurochemical Research 2009 34 10 1792 1804 2-s2.0-69049101050 10.1007/s11064-009-9985-9
41. Gandolfo G., Scherschlicht R., Gottesmann C., Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacology Biochemistry and Behavior 1994 49 4 921 927 2-s2.0-0028034454 10.1016/0091-3057(94)90244-5 (Pubitemid 24376031)
42. Tobler I., Kopp C., Deboer T., Rudolph U., Diazepam-induced changes in sleep: role of the α 1 GABAA receptor subtype. Proceedings of the National Academy of Sciences of the United States of America 2001 98 11 6464 6469 2-s2.0-0035933064 10.1073/pnas.111055398 (Pubitemid 32488260)
43. Halász P., Terzano M., Parrino L., Bódizs R., The nature of arousal in sleep. Journal of Sleep Research 2004 13 1 1 23 2-s2.0-17044448781 10.1111/j.1365-2869.2004.00388.x (Pubitemid 38365716)
44. 2+ channel plays a crucial role in stabilizing sleep. Proceedings of the National Academy of Sciences of the United States of America 2005 102 5 1743 1748 2-s2.0-13444263254 10.1073/pnas.0409644102 (Pubitemid 40209238)
45. 2+ channels and NREM sleep. Cell Calcium 2006 40 2 175 190 2-s2.0-33745333405 10.1016/j.ceca.2006.04.022 (Pubitemid 43942299)
46. Wafford K. A., Ebert B., Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time. Nature Reviews Drug Discovery 2008 7 6 530 540 2-s2.0-44449104126 10.1038/nrd2464 (Pubitemid 351767120)