Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Waltz, Xavier ^a,b   Pichon, Aurélien ^b,c   Lemonne, Nathalie ^d   Mougenel, Danièle ^d   Lalanne Mistrih, Marie Laure ^a,e   Lamarre, Yann ^a,b   Tarer, Vanessa ^d   Tressières, Benoit ^e   Etienne Julan, Maryse ^d   Hardy Dessources, Marie Dominique ^a,b   Hue, Olivier ^a   Connes, Philippe ^a,b  

^a UNIVERSITÉ DES ANTILLES ET DE LA GUYANE   (France)

^b Laboratory of Excellence GR Ex 'The red cell from genesis to death' PRES Sorbonne Paris Cité   (France)

^c UNIVERSITÉ PARIS 13   (France)

^d Centre Hospitalier et Universitaire   (France)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEMATOLOGIC DISEASE; HEMOGLOBIN SC DISEASE; HUMAN; HUMAN CELL; MALE; MICROANGIOPATHY; MICROCIRCULATION; MULTIVARIATE ANALYSIS; MUSCLE BLOOD FLOW; MUSCLE FATIGUE; MUSCLE FUNCTION; MUSCLE METASTASIS; MUSCLE OXYGEN CONSUMPTION; MUSCLE STRENGTH; OXYGEN CONSUMPTION; SICKLE CELL ANEMIA;

ADULT; ANEMIA, SICKLE CELL; FEMALE; FOREARM; FOURIER ANALYSIS; HEMORHEOLOGY; HUMANS; LINEAR MODELS; MALE; MICROVESSELS; MULTIVARIATE ANALYSIS; MUSCLE FATIGUE; MUSCLES; OXYGEN; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; REST;

EID: 84871417398     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052471     Document Type: Article

References (45)

1. Kaul DK, Fabry ME, (2004) In vivo studies of sickle red blood cells. Microcirculation 11: 153-165.
2. Lamarre Y, Romana M, Waltz X, Lalanne-Mistrih ML, Tressières B,et al. (In press) Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in sickle cell disease. Haematologia
3. Nebor D, Bowers A, Hardy-Dessources MD, Knight-Madden J, Romana M, et al. (2011) Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation. Haematologica 96: 1589-1594.
4. Ballas SK, Smith ED, (1992) Red blood cell changes during the evolution of the sickle cell painful crisis. Blood 79: 2154-2163.
5. Connes P, Machado R, Hue O, Reid H, (2011) Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clin Hemorheol Microcirc 49: 151-163.
6. Tavakkoli F, Nahavandi M, Wyche MQ, Castro O, (2005) Effects of hydroxyurea treatment on cerebral oxygenation in adult patients with sickle cell disease: an open-label pilot study. Clin Ther 27: 1083-1088.
7. Raj A, Bertolone SJ, Mangold S, Edmonds HL Jr, (2004) Assessment of cerebral tissue oxygenation in patients with sickle cell disease: effect of transfusion therapy. J Pediatr Hematol Oncol 26: 279-283.
8. Nahavandi M, Tavakkoli F, Hasan SP, Wyche MQ, Castro O, (2004) Cerebral oximetry in patients with sickle cell disease. Eur J Clin Invest 34: 143-148.
9. Callahan LA, Woods KF, Mensah GA, Ramsey LT, Barbeau P, et al. (2002) Cardiopulmonary responses to exercise in women with sickle cell anemia. Am J Respir Crit Care Med 165: 1309-1316.
10. Parthasarathi K, Lipowsky HH, (1999) Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability. Am J Physiol 277: H2145-2157.
11. Rodgers GP, Schechter AN, Noguchi CT, Klein HG, Nienhuis AW, et al. (1984) Periodic microcirculatory flow in patients with sickle-cell disease. N Engl J Med 311: 1534-1538.
12. Aalkjaer C, Boedtkjer D, Matchkov V, (2011) Vasomotion- what is currently thought? Acta Physiol (Oxf) 202: 253-269.
13. Thorn CE, Kyte H, Slaff DW, Shore AC, (2011) An association between vasomotion and oxygen extraction. Am J Physiol Heart Circ Physiol 301: H442-449.
14. Kislukhin VV, (2010) Stochasticity of flow through microcirculation as a regulator of oxygen delivery. Theor Biol Med Model 7: 29.
15. Tsai AG, Intaglietta M, (1993) Evidence of flowmotion induced changes in local tissue oxygenation. Int J Microcirc Clin Exp 12: 75-88.
16. Perrey S, (2008) Non-invasive NIR spectroscopy of human brain function during exercise. Methods 45: 289-299.
17. Ferrari M, Mottola L, Quaresima V, (2004) Principles, techniques, and limitations of near infrared spectroscopy. Can J Appl Physiol 29: 463-487.
18. Nahavandi M, Nichols JP, Hassan M, Gandjbakhche A, Kato GJ, (2009) Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals. Hematology 14: 46-48.
19. van Beekvelt MC, Borghuis MS, van Engelen BG, Wevers RA, Colier WN, (2001) Adipose tissue thickness affects in vivo quantitative near-IR spectroscopy in human skeletal muscle. Clin Sci (Lond) 101: 21-28.
20. Van Beekvelt MC, Colier WN, Wevers RA, Van Engelen BG, (2001) Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscle. J Appl Physiol 90: 511-519.
21. Hamaoka T, Katsumura T, Murase N, Sako T, Higuchi H, et al. (2003) Muscle oxygen consumption at onset of exercise by near infrared spectroscopy in humans. Adv Exp Med Biol 530: 475-483.
22. Li Z, Leung JY, Tam EW, Mak AF (2006) Wavelet analysis of skin blood oscillations in persons with spinal cord injury and able-bodied subjects. Arch Phys Med Rehabil 87: 1207-1212; quiz 1287.
23. Soderstrom T, Stefanovska A, Veber M, Svensson H, (2003) Involvement of sympathetic nerve activity in skin blood flow oscillations in humans. Am J Physiol Heart Circ Physiol 284: H1638-1646.
24. Rossi M, Carpi A, Galetta F, Franzoni F, Santoro G, (2006) The investigation of skin blood flowmotion: a new approach to study the microcirculatory impairment in vascular diseases? Biomed Pharmacother 60: 437-442.
25. Kvandal P, Stefanovska A, Veber M, Kvernmo HD, Kirkeboen KA, (2003) Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: importance of nitric oxide and prostaglandines. Microvasc Res 65: 160-171.
26. Stefanovska A, Bracic M, Kvernmo HD, (1999) Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng 46: 1230-1239.
27. Kvernmo HD, Stefanovska A, Kirkeboen KA, Kvernebo K, (1999) Oscillations in the human cutaneous blood perfusion signal modified by endothelium-dependent and endothelium-independent vasodilators. Microvasc Res 57: 298-309.
28. Baskurt OK, Boynard M, Cokelet GC, Connes P, Cooke BM, et al. (2009) New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 42: 75-97.
29. Hardeman MR, Dobbe JG, Ince C, (2001) The Laser-assisted Optical Rotational Cell Analyzer (LORCA) as red blood cell aggregometer. Clin Hemorheol Microcirc 25: 1-11.
30. Waltz X, Hedreville M, Sinnapah S, Lamarre Y, Soter V,et al. (In press) Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia. Clin Hemorheol Microcirc.
31. Tripette J, Alexy T, Hardy-Dessources MD, Mougenel D, Beltan E, et al. (2009) Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease. Haematologica 94: 1060-1065.
32. Baskurt OK, Meiselman HJ, (2008) RBC aggregation: more important than RBC adhesion to endothelial cells as a determinant of in vivo blood flow in health and disease. Microcirculation 15: 585-590.
33. Baskurt OK, Meiselman HJ, (2007) Hemodynamic effects of red blood cell aggregation. Indian J Exp Biol 45: 25-31.
34. Buison AM, Kawchak DA, Schall JI, Ohene-Frempong K, Stallings VA, et al. (2005) Bone area and bone mineral content deficits in children with sickle cell disease. Pediatrics 116: 943-949.
35. Buchowski MS, de la Fuente FA, Flakoll PJ, Chen KY, Turner EA, (2001) Increased bone turnover is associated with protein and energy metabolism in adolescents with sickle cell anemia. Am J Physiol Endocrinol Metab 280: E518-527.
36. Badaloo A, Jackson AA, Jahoor F, (1989) Whole body protein turnover and resting metabolic rate in homozygous sickle cell disease. Clin Sci (Lond) 77: 93-97.
37. Seakins M, Gibbs WN, Milner PF, Bertles JF, (1973) Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia. J Clin Invest 52: 422-432.
38. Brown MM, Wade JP, Marshall J, (1985) Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain 108 (Pt 1): 81-93.
39. Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, et al. (2009) Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) 24: 107-116.
40. Pittman RN (2011) Regulation of tissue oxygenation. In: sciences MCl, editor. Integrated systems physiology: from molecule to function to disease. 2011/06/03 ed. San Rafael (CA).
41. Waypa GB, Schumacker PT, (2010) Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor? Respir Physiol Neurobiol 174: 201-211.
42. Connes P, Coates TD (In press) Autonomic nervous system dysfunction: implication in sickle cell disease. C R Biol.
43. Dougherty KA, Schall JI, Rovner AJ, Stallings VA, Zemel BS, (2011) Attenuated maximal muscle strength and peak power in children with sickle cell disease. J Pediatr Hematol Oncol 33: 93-97.
44. De Luca CJ, (1997) The use of surface electromyography in biomechanics. J Appl Biomech 13: 135-163.
45. Balayssac-Siransy E, Connes P, Tuo N, Danho C, Diaw M, et al. (2011) Mild haemorheological changes induced by a moderate endurance exercise in patients with sickle cell anaemia. Br J Haematol 154: 398-407.