Characterization of homoisoflavonoids in different cultivation regions of Ophiopogon japonicus and related antioxidant activity

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 5, 2010, Pages 757-762

  Lin, Yining ^a   Zhu, Danni ^a   Qi, Jin ^a   Qin, Minjian ^a   Yu, Boyang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antioxidant activity; Chemical profile; Homoisoflavonoids; LC ESI MS MS; Ophiopogon japonicus

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 5 HYDROXY 7 METHOXY 3',4' METHYLENE DIOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5 HYDROXY 7,4' DIMETHOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5,2' DIHYDROXY 7,4' DIMETHOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5,2' DIHYDROXY 7,8,4' TRIMETHOXY 6 METHYLHOMOISOFLAVONE; 5,7 DIHYDROXY 4' METHOXY 6 METHYLHOMOISOFLAVONE; 5,7 DIHYDROXY 8,4' DIMETHOXY 6 METHYLHOMOISOFLAVONE; 5,7' DIHYDROXY 8 METHOXY 3',4' METHYLENE DIOXY 6 METHYLHOMOISOFLAVONE; 5,7,2' TRIHYDROXY 3',4' METHYLENE DIOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5,7,2' TRIHYDROXY 4' METHOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5,7,4' TRIHYDROXY 3' METHOXY 6,8 DIMETHYLHOMOISOFLAVONE; 5,7,4' TRIHYDROXY 3',5' DIMETHOXY 6,8 DIMETHYLHOMOISOFLAVONE; 6 ALDEHYDO ISOOPHIOPOGONANONE A; 6 ALDEHYDO ISOOPHIOPOGONONE A; 6 ALDEHYDO ISOOPHIOPOGONONE B; 8 ALDEHYDO 7 HYDROXY 5,4' DIMETHOXY 6 METHYLHOMOISOFLAVONE; HERBACEOUS AGENT; HOMOISOFLAVONOID; ISOFLAVONOID; METHYLOPHIOPOGONANONE A; METHYLOPHIOPOGONANONE B; METHYLOPHIOPOGONONE A; METHYLOPHIOPOGONONE B; OPHIOPOGON JAPONICUS EXTRACT; OPHIOPOGONANONE A; OPHIOPOGONANONE C; OPHIOPOGONANONE D; OPHIOPOGONANONE E; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; NONHUMAN; OPHIOPOGON JAPONICUS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; OPHIOPOGON; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 77950865976     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.016     Document Type: Article

References (19)

1. Kou J.P., Yu B.Y., Xu Q. Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities. Vasc. Pharmacol. 2005, 43:157-163.
2. Ishibashi H., Mochidome T., Okai J., Ichiki H., Shimada H., Takahama K. Activation of potassium conductance by ophiopogonin-D in acutely dissociated rat paratracheal neurones. Br. J. Pharmacol. 2001, 132:461-466.
3. Choi S.B., Wha J.D., Park S.M. The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway. Life Sci. 2004, 75:2653-2664.
4. Watanabe Y., Hirai Y., Sanada S., Ida Y., Tanaka T., Shoji J. Comparative studies on the constituents of Ophiopogonis tuber and its congeners (Part V). Studies on the constituents of the subterranean part of Ophiopogon chekiangensis K. KIMURA et H. MIGO. Shoyakugaku Zasshi 1990, 44:117-121.
5. Hu S.L. The Authentic and Superior Medicinal Herbals in China 1989, Heilongjiang Technology and Science Publishing House, Heilongjiang, pp. 165.
6. Carmona M., Sánchez A.M., Ferreres F., Zalacain A., Tomás-Barberán F., Alonso G.L. Identification of the flavonoid fraction in saffron spice by LC/DAD/MS/MS: comparative study of samples from different geographical origins. Food Chem. 2007, 100:445-450.
7. Zhou Y.F., Qi J., Zhu D.N., Yu B.Y. Homoisoflavonoids from Ophiopogon japonicus and its oxygen free radicals (OFRs) scavenging effects. Chin. J. Nat. Med. 2008, 6:201-204.
8. Kou J.P., Tian Y.Q., Tang Y.K., Yan J., Yu B.Y. Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol. Pharm. Bull. 2006, 29:1267-1270.
9. Nguyen T.H.A., Tran V.S., Andrea P., Katrin F., Ludger W.A. Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler. Phytochemistry 2003, 62:1153-1158.
10. Chang J.M., Shen C.C., Huang Y.L., Chien M.Y., Ou J.C., Shieh B.J., Chen C.C. Five new homoisoflavonoids from the tuber of Ophiopogon japonicus. J. Nat. Prod. 2002, 65:1731-1733.
11. Lin Y.N., Shida Y., Yuan B., Cheng Z.H., Yu B.Y., Zhu D.N. Comparative studies on fingerprints of root of Ophiopogon japonicus cultivated in different areas. J. China Pharm. Univ. 2005, 36:538-542.
12. Liu L., Lu Y., Shao Q., Cheng Y.Y., Qu H.B. Binary chromatographic fingerprinting for quality evaluation of Radix Ophiopogonis by highperformance liquid chromatography coupled with ultraviolet and evaporative light-scattering detectors. J. Sep. Sci. 2007, 30:2628-2637.
13. n. J. Am. Soc. Mass Spectrom. 2005, 16:234-243.
14. Ye G., Ye M., Guo D.A., Huang C.G. Determination of homoisoflavonoids in Ophiopogon japonicus by RP-HPLC. Chromatographia 2005, 61:121-125.
15. Singleton V.L., Rossi J.A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 1965, 16:144-158.
16. Brand-Williams W., Cuvelier M.E., Berset C. Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci. Technol. 1995, 28:25-30.
17. Clemens S., Barz W. Cytochrome P450-dependent methylenedioxy bridge formation in Cicer arietinum. Phytochemistry 1996, 41:457-460.
18. Nguyen A.T., Fontaine J., Malonne H., Duez P. Homoisoflavanones from Disporopsis aspera. Phytochemistry 2006, 67:2159-2163.
19. Chen Y.G., Dai J.D., Gu H.F. Determination of methylophiopogonanones A and B in Radix Ophiopogonis and its extracts by HPLC. Chin. Tradit. Herb Drugs. 2007, 38:1640-1643.