Tri- and diorganotin(IV) complexes of biologically important orotic acid: Synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 310-321

  Nath, Mala ^a   Vats, Monika ^a   Roy, Partha ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Anti cancer; Anti inflammatory; DNA ladder; Enzyme assay; Organotin carboxylates

Indexed keywords

GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; ORGANOTIN COMPOUND; OROTIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CELL; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CELL STRAIN HEK293; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ASSAY; FEMALE; GEOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROPHOTOMETRY; KIDNEY CANCER; KIDNEY CELL; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; INFUSIONS, PARENTERAL; MICE; MOLECULAR STRUCTURE; ORGANOTIN COMPOUNDS; OROTIC ACID; TIN;

EID: 84871373295     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.023     Document Type: Article

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