Induction of apoptosis by 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol from Isaria japonica Yasuda through intracellular reactive oxygen species formation and caspase-3 activation in human leukemia HL-60 cells

Toxicology in Vitro

Volumn 17, Issue 1, 2003, Pages 49-57

  Pae, H O ^a   Oh, G S ^a   Choi, B M ^a   Seo, E A ^a   Oh, H ^b   Shin, M K ^b   Kim, T H ^b   Kwon, T O ^a   Chung, H T ^a  

^a 570 749   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

4 Acetyl 12,13 epoxyl 9 trichothecene 3,15 diol; Apoptosis; Caspase 3; Isaria japonica Yasuda; Reactive oxygen species; Trichothecene

Indexed keywords

4 ACETYL 12,13 EPOXYL 9 TRICHOTHECENE 3,15 DIOL; ACETYLCYSTEINE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; GLUTATHIONE; LIPOCORTIN 5; REACTIVE OXYGEN METABOLITE; TRICHOTHECENE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL LINE; CELL POPULATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; FUNGUS; HUMAN; HUMAN CELL; ISARIA JAPONICA YASUDA;

APOPTOSIS; ASCOMYCOTA; CASPASE 3; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HL-60 CELLS; HUMANS; REACTIVE OXYGEN SPECIES; TRICHOTHECENES;

ISARIA JAPONICA; JAPONICA;

EID: 0037300349     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(02)00097-8     Document Type: Article

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