A new drug delivery system for intravenous coronary thrombolysis with thrombus targeting and stealth activity recoverable by ultrasound

Journal of the American College of Cardiology

Volumn 60, Issue 24, 2012, Pages 2550-2557

  Kawata, Hiroyuki ^a   Uesugi, Yoshiko ^b   Soeda, Tsunenari ^a   Takemoto, Yasuhiro ^a   Sung, Ji Hee ^a   Umaki, Kiyotaka ^c   Kato, Keiji ^c   Ogiwara, Kenichi ^a   Nogami, Keiji ^a   Ishigami, Kenichi ^a   Horii, Manabu ^a   Uemura, Shiro ^a   Shima, Midori ^a   Tabata, Yasuhiko ^b   Saito, Yoshihiko ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Medical System Engineering Department   (Japan)

Author keywords

acute myocardial infarction; drug delivery system; plasminogen activators; thrombolysis; ultrasound

Indexed keywords

GELATIN; IODINE 125; MONTEPLASE; NANOPARTICLE; VON WILLEBRAND FACTOR; ZINC ACETATE;

ACUTE HEART INFARCTION; ANGIOCARDIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY RECANALIZATION; CORONARY ARTERY THROMBOSIS; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG TARGETING; FEMALE; FEMORAL ARTERY; HEART LEFT VENTRICLE EJECTION FRACTION; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWINE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; CORONARY OCCLUSION; CORONARY THROMBOSIS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG PACKAGING; FIBRINOLYTIC AGENTS; GELATIN; INJECTIONS, INTRAVENOUS; MYOCARDIAL INFARCTION; NANOPARTICLES; SOUND; STROKE VOLUME; SWINE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; VENTRICULAR FUNCTION, LEFT; ZINC ACETATE;

EID: 84871337715     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.08.1008     Document Type: Article

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