Adjunctive Transcutaneous Ultrasound With Thrombolysis. Results of the PLUS (Perfusion by ThromboLytic and UltraSound) Trial

JACC: Cardiovascular Interventions

Volumn 3, Issue 3, 2010, Pages 352-359

  Hudson, Michael ^a   Greenbaum, Adam ^a   Brenton, Laura ^a   Gibson, C Michael ^b   Siegel, Robert ^c   Reeves, Lisa R ^d   Sala, Miguel Fiol ^e   McKendall, George ^f   Bluguermann, Jorge ^g   Echt, Debra ^h   Ohman, E Magnus ⁱ   Weaver, W Douglas ^a  

^a HENRY FORD HEART AND VASCULAR INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d i3 Statprobe   (United States)

^e Hospital San Dureta   (Spain)

^f RHODE ISLAND HOSPITAL   (United States)

^g Policlinico Bancario   (Argentina)

^h Timi3 Systems Inc   (United States)

ⁱ DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

acute myocardial infarction; angioplasty; fibrinolysis; reperfusion; ultrasound

Indexed keywords

RETEPLASE; TENECTEPLASE;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; CEREBROVASCULAR ACCIDENT; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOUBLE BLIND PROCEDURE; ELECTROCARDIOGRAPHY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART RUPTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TRANSCUTANEOUS ULTRASOUND; ULTRASOUND THERAPY;

AGED; ARGENTINA; COMBINED MODALITY THERAPY; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; DOUBLE-BLIND METHOD; EARLY TERMINATION OF CLINICAL TRIALS; ELECTROCARDIOGRAPHY; EQUIPMENT DESIGN; EUROPE; FEMALE; HEART RUPTURE, POST-INFARCTION; HEMORRHAGE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NORTH AMERICA; RECURRENCE; RISK ASSESSMENT; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TREATMENT OUTCOME; ULTRASONIC THERAPY;

EID: 77949340173     PISSN: 19368798     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcin.2009.11.020     Document Type: Article

References (34)

1. White H.D., and Van de Werf F.J. Thrombolysis for acute myocardial infarction. Circulation 97 (1998) 1632-1646
2. The Gusto Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function, and survival after myocardial infarction. N Engl J Med 329 (1993) 1615-1622
3. Vogt A., Von Essen R., Tebbe U., Feuerer W., Appel K.F., and Neuhaus K.L. Impact of early perfusion status of the infarct-related artery on short-term mortality after thrombolysis for acute myocardial infarction: retrospective analysis of four German multicenter studies. J Am Coll Cardiol 21 (1993) 1391-1395
4. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial: phase 1 findings. N Engl J Med 312 (1985) 932-936
5. Gibson C.M., Cannon C.P., Murphy S.A., et al., TIMI (Thombolysis In Myocardial Infarction) Study Group. Relationship of TIMI myocardial perfusion grade to mortality after thrombolytic administration. Circulation 101 (2000) 125-130
6. Gibson C.M., and Schomig A. Coronary and myocardial angiography: angiographic assessment of both epicardial and myocardial perfusion. Circulation 109 (2004) 3096-3105
7. Roe M.T., Ohman E.M., Maas A.C.P., et al. Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion. J Am Coll Cardiol 37 (2001) 9-18
8. Claeys M.J., Bosmans J., Veenstra L., Jorens P., De Raedt H., and Vrints C.J. Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation 99 (1999) 1972-1977
9. Atar S., and Rosenschein U. Perspectives on the role of ultrasonic devices in thrombolysis. J Thromb Thrombol 17 (2004) 107-114
10. Luo H., Nishioka T., Fishbein M.C., et al. Transcutaneous ultrasound augments lysis of arterial thrombi in vivo. Circulation 94 (1996) 775-778
11. Luo H., Birnbaum Y., Fishbein M.C., et al. Enhancement of thrombolysis in vivo without skin and soft tissue damage by transcutaneous ultrasound. Thrombosis Res 89 (1998) 171-177
12. Suchkova V.N., Siddiqi F.N., Carstensen E.L., Dalecki D., Child S., and Francis C.W. Enhancement of fibrinolysis with 40-kHz ultrasound. Circulation 98 (1998) 1030-1035
13. Suchkova V.N., Baggs R.B., and Francis C.W. Effect of 40-kHz ultrasound on acute thrombotic ischemia in rabbit femoral artery thrombosis model. Circulation 101 (2000) 2296-2301
14. Siegel R.J., Atar S., Fishbein M.C., et al. Noninvasive, transthoracic low-frequency ultrasound augments thrombolysis in a canine model of acute myocardial infarction. Circulation 101 (2000) 2026-2029
15. Siegel R.J., Suchkova V.N., Miyamoto T., et al. Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion. J Am Coll Cardiol 44 (2004) 1454-1458
16. Siddiqi F.N., Blinc A., Braaten J., and Francis C.W. Ultrasound increases flow through fibrin gels. Thromb Haemost 73 (1995) 495-498
17. Braaten J.V., Goss R.A., and Francis C.W. Ultrasound reversibly disaggregates fibrin fibers. Thromb Haemost 78 (1997) 1063-1068
18. Miyamoto T., Neuman Y., Luo H., et al. Coronary vasodilation by noninvasive transcutaneous ultrasound-an in vivo canine study. J Am Coll Cardiol 41 (2003) 1623-1627
19. Cohen M.G., Tuero E., Bluguermann J., et al. Transcutaneous ultrasound facilitated coronary thrombolysis during acute myocardial infarction. Am J Cardiol 92 (2003) 454-457
20. Gibson C.M., Cannon C.P., Daley W.L., et al. TIMI frame count: a quantitative method of assessing coronary flow. Circulation 93 (1996) 879-888
21. Gibson C.M., Murphy S.A., Rizzo M.J., et al., Thrombolysis In Myocardial Infarction (TIMI) Study Group. The relationship between the TIMI frame count and clinical outcomes after thrombolytic administration. Circulation 99 (1999) 1945-1950
22. Gibson C.M., Cannon C.P., Murphy S.A., et al., TIMI (Thrombolysis In Myocardial Infarction) Study Group. Relationship of the TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation 101 (2000) 125-130
23. Gibson C.M., Cannon C.P., Murphy S.A., Marble S.J., Barron H.V., and Braunwald E. Relationship of the TIMI myocardial perfusion grades, flow grades, frame count and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute MI. Circulation 105 (2002) 1909-1913
24. Schroeder R., Dissman R., Bruggermann T., et al. Extent of early ST-segment resolution; a simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol 24 (1994) 384-391
25. Schroeder R., Wegscheider K., Schroder K., Dissman R., Meyer-Sabellek W., and INJECT Trial Group. Extent of early ST-segment resolution: a strong predictor of outcome in patients with acute myocardial infarction a sensitive measure to compare thrombolytic regimens. A substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. J Am Coll Cardiol 26 (1995) 1657-1664
26. Alexandrov A.V., Molina C.A., Grotta J.C., et al., CLOTBUST Investigators. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 351 (2004) 2170-2178
27. Iida K., Luo K., Hagisawa K., et al. Noninvasive low-frequency ultrasound energy causes vasodilation in humans. J Am Coll Cardiol 48 (2006) 532-537
28. Antman E.M., Giugliano R.P., Gibson C.M., et al., TIMI 14 Investigators. Abciximab facilitates the rate and extent of thrombolysis: results of the Thrombolysis In Myocardial Infarction (TIMI) 14 trial. Circulation 99 (1999) 2720-2732
29. Brener S.J., Zeymer U., Adgey A.A.J., et al., INTRO AMI Investigators. Eptifibatide and low-dose tissue plasminogen activator in acute myocardial infarction: the Integrilin and Low-Dose Thrombolysis in Acute Myocardial Infarction (INTRO AMI) trial. J A Coll Cardiol 39 (2002) 377-386
30. DeLemos J.A., Antman E.M., Gugliano R.P., et al., In-TIME-II Investigators. Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. Am J Cardiol 86 (2000) 1235-1237
31. Purcell I.F., Newall N., and Farrer M. Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes. Heart 78 (1997) 465-471
32. Barbash G.I., Roth A., Hod H., et al. Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of early intervention in myocardial infarction. Br Heart J 64 (1990) 241-247
33. van'T Hof A.W.J., Liem A., de Boer M.J.D., Zijlstra F., and Zwolle Myocardial Infarction Study Group. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Lancet 350 (1997) 615-619
34. Bekeredjian R., Grayburn P.A., and Shohet R.V. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol 45 (2005) 329-335