Effect of VEGF on angiogenesis in pedicle penile skin flaps: An experimental study of urethral reconstruction in rabbits

European Journal of Pediatric Surgery

Volumn 22, Issue 6, 2012, Pages 460-464

  Efstathiou, Elefteria ^a   Gardikis, Stefanos ^a   Giatromanolaki, Alexandra ^a   Kambouri, Katerina ^a   Sivridis, Efthimios ^a   Simopoulos, Constantinos ^a   Vaos, George ^a  

^a University Hospital Alexandroupolis   (Greece)

Author keywords

angiogenesis; pedicle penile skin flap; rabbit; urethral reconstruction; vascular endothelial growth factor

Indexed keywords

RECOMBINANT VASCULOTROPIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PEDICLED PENIS SKIN FLAP; PEDICLED SKIN FLAP; POSTOPERATIVE PERIOD; PROTEIN EXPRESSION; RABBIT; URETHRA MALFORMATION; URETHROPLASTY; WOUND CLOSURE;

ANALYSIS OF VARIANCE; ANGIOGENESIS INDUCING AGENTS; ANIMALS; IMMUNOHISTOCHEMISTRY; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PENIS; RABBITS; RECONSTRUCTIVE SURGICAL PROCEDURES; SKIN TRANSPLANTATION; SURGICAL FLAPS; URETHRA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84871326211     PISSN: 09397248     EISSN: 1439359X     Source Type: Journal    
DOI: 10.1055/s-0032-1315808     Document Type: Article

References (30)

1. Baskin L. S. Hypospadias. In: Grosfeld J. L., O'Neill J. A., Coran A. G., Fonkalsrud E. W. eds. Pediatric Surgery. 6th ed. Philadelphia Mosby: 2006; 1870 1898
2. Snodgrass W. T. Hypospadias urethroplasty. In: Wilcox D. T., Godbole P. P., Koyle M. A., eds. Pediatric Urology: Surgical Complications and Management. 1st ed. West Sussex Wiley-Blackwell: 2008; 201 211
3. Daniel R. K., Kerrigan C. L. Principles and physiology of skin flap surgery. In: McCarthy J. G. ed. Plastic Surgery, 3rd ed. Philadelphia Saunders: 1990; 275 328
4. Marti H. H., Risau W. Angiogenesis in ischemic disease. Thromb Haemost: 1999; 82 01 44 52
5. Ferrara N., Gerber H. P., LeCouter J. The biology of VEGF and its receptors. Nat Med: 2003; 9 6 669 676
6. Zachary I. Vascular endothelial growth factor. Int J Biochem Cell Biol: 1998; 30 11 1169 1174
7. Chodak G. W., Thisted R. A., Gerber G. S., et al. Results of conservative management of clinically localized prostate cancer. N Engl J Med: 1994; 330 4 242 248
8. Yang R., Thomas G. R., Bunting S., et al. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol: 1996; 27 6 838 844
9. Alon T., Hemo I., Itin A., Pe'er J., Stone J., Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med: 1995; 1 10 1024 1028
10. Risau W. Mechanisms of angiogenesis. Nature: 1997; 386 6626 671 674
11. Tonnesen M. G., Feng X., Clark R. A. Angiogenesis in wound healing. J Investig Dermatol Symp Proc: 2000; 5 1 40 46
12. Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature: 1992; 359 6398 843 845
13. Liu Y., Cox S. R., Morita T., Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ Res: 1995; 77 3 638 643
14. Gardikis S., Giatromanolaki A., Ypsilantis P., et al. Comparison of angiogenic activities after urethral reconstruction using free grafts in rabbits. Eur Urol: 2005; 47 3 417 421
15. Kambouri K., Gardikis S., Giatromanolaki A., et al. Comparison of angiogenic activity after urethral reconstruction using free grafts and pedicle flap: an experimental study. Eur J Pediatr Surg: 2006; 16 5 323 328
16. Lineaweaver W. C., Lei M. P., Mustain W., Oswald T. M., Cui D., Zhang F. Vascular endothelium growth factor, surgical delay, and skin flap survival. Ann Surg: 2004; 239 6 866 873, discussion 873-875
17. Wagatsuma A. Endogenous expression of angiogenesis-related factors in response to muscle injury. Mol Cell Biochem: 2007; 298 1-2 151 159
18. Zhang F., Oswald T., Lin S., et al. Vascular endothelial growth factor (VEGF) expression and the effect of exogenous VEGF on survival of a random flap in the rat. Br J Plast Surg: 2003; 56 7 653 659
19. Lindenblatt N., Calcagni M., Contaldo C., Menger M. D., Giovanoli P., Vollmar B. A new model for studying the revascularization of skin grafts in vivo: the role of angiogenesis. Plast Reconstr Surg: 2008; 122 6 1669 1680
20. Takeshita S., Zheng L. P., Brogi E., et al. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest: 1994; 93 2 662 670
21. Zhang Z. G., Zhang L., Jiang Q., et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest: 2000; 106 7 829 838
22. Guzman M. J., Crisostomo P. R., Wang M., Markel T. A., Wang Y., Meldrum D. R. Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury. J Surg Res: 2008; 150 2 286 292
23. Yoshikawa T., Tohyama H., Katsura T., et al. Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Am J Sports Med: 2006; 34 12 1918 1925
24. Seipelt R. G., Backer C. L., Mavroudis C., et al. Topical VEGF enhances healing of thoracic aortic anastomosis for coarctation in a rabbit model. Circulation: 2003; 108 Suppl 1 II150 II154
25. Ishii M., Tanaka E., Imaizumi T., et al. Local VEGF administration enhances healing of colonic anastomoses in a rabbit model. Eur Surg Res: 2009; 42 4 249 257
26. Zhang F., Lei M. P., Oswald T. M., et al. The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds. Br J Plast Surg: 2003; 56 4 334 341
27. Galiano R. D., Tepper O. M., Pelo C. R., et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol: 2004; 164 6 1935 1947
28. Kryger Z., Zhang F., Dogan T., Cheng C., Lineaweaver W. C., Buncke H. J. The effects of VEGF on survival of a random flap in the rat: examination of various routes of administration. Br J Plast Surg: 2000; 53 3 234 239
29. Vourtsis S. A., Spyriounis P. K., Agrogiannis G. D., Ionac M., Papalois A. E. VEGF application on rat skin flap survival. J Invest Surg: 2012; 25 1 14 19
30. Simons M. Angiogenesis: where do we stand now? Circulation: 2005; 111 12 1556 1566