The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds

British Journal of Plastic Surgery

Volumn 56, Issue 4, 2003, Pages 334-341

  Zhang, F ^a   Lei, M P ^a   Oswald, T M ^a   Pang, Y ^a   Blain, B ^a   Cai, Z W ^a   Lineaweaver, W C ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Skin; Tensile strength; Vascular endothelial growth factor; Wound healing

Indexed keywords

RECOMBINANT VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; ISCHEMIA; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; SKIN FLAP; SKIN INCISION; SKIN INJURY; TENSILE STRENGTH; WOUND HEALING;

EID: 0042167333     PISSN: 00071226     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0007-1226(03)00175-9     Document Type: Article

References (35)

1. Thompson WD, Harvey JA, Kazmi MA, Stout AJ. Fibrinolysis and angiogenesis in wound healing. J Pathol 1991;165: 311-8.
2. Arnold F, West DC. Angiogenesis in wound healing. Pharmacol Ther 1991;52:407-22.
3. Hockel M, Jung W, Vaupel P, Rabes H, Khaledpour C, Wissler JH. Purified monocyte-derived angiogenic substance (angiotropin) induces controlled angiogenesis associated with regulated tissue proliferation in rabbit skin. J Clin Invest 1988;82:1075-90.
4. Stadelmann WK, Digenis AG, Tobin GR. Impediments to wound healing. Am J Surg 1998;176:39S-47S.
5. Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Heating of diabetic foot ulcers and pressure ulcers with human skin equivalent, a new paradigm in wound heating. Arch Surg 2000;135:627-34.
6. Galeano M, Torre V, Deodato B, et al. Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice. Surgery 2001;129: 467-77.
7. Hockel M, Schlenger K, Doctrow S, Kissel T, Vaupel P. Therapeutic angiogenesis. Arch Surg 1993;128:423-9.
8. Zhao LL, Davidson JD, Wee SC, Roth SI, Mustoe TA. Effect of hyperbaric oxygen and growth factors on rabbit ear ischemic ulcers. Arch Surg 1994;129:1043-9.
9. Stadelmann WK, Digenis AG, Tobin GR. Physiology and heating dynamics of chronic cutaneous wounds. Am J Surg 1998;176:26S-38S.
10. Steed DL. The role of growth factors in wound healing. Surg Clin North Am 1997;77:575-86.
11. Breitbart AS, Grande DA, Laser J, et al. Treatment of ischemic wounds using cultured dermal fibroblasts transduced retrovirally with PDGF-B and VEGF121 genes. Ann Plast Surg 2001;46:555-61.
12. Xia YP, Zhao Y, Marcus J, et al. Effects of keratinocyte growth factor-2 (KGF-2) on wound heating in an ischaemia-impaired rabbit ear model and on scar formation. J Pathol 1999;188:431-8.
13. Uhl E, Barker JH, Bondar I, et al. Basic fibroblast growth factor accelerates wound healing in chronically ischaemic tissue. Br J Surg 1993;80:977-80.
14. Quirinia A, Viidik A. The effect of recombinant basic fibroblast growth factor (bFGF) in fibrin adhesive vehicle on the healing of ischaemic and normal incisional skin wounds. Scand J Plast Reconstr Surg Hand Surg 1998;32: 9-18.
15. Wu L, Pierce GF, Galiano RD, Mustoe TA. Keratinocyte growth factor induces granulation tissue in ischemic dermal wounds. Importance of epithelial-mesenchymal cell interactions. Arch Surg 1996;131:660-6.
16. Flamme I, von Reutern M, Drexler HC, Syed-Ali S, Risau W. Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation. Dev Biol 1995;171:399-414.
17. Hippenstiel S, Krull M, Ikemann A, Risau W, Clauss M, Suttorp N. VEGF induces hyperpermeability by a direct action on endothelial cells. Am J Physiol 1998;274:L678-84.
18. Bernatchez PN, Soker S, Sirois MG. Vascular endothelial growth factor effect on endothetial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. J Biol Chem 1999;274:31047-54.
19. Quirinia A, Jensen FT, Viidik A. Ischemia in wound healing. I: Design of a flap model-changes in blood flow. Scand J Plast Reconstr Surg Hand Surg 1992;26:21-8.
20. Quirinia A, Viidik A. Ischemia in wound healing. II: Design of a flap model-biomechanical properties. Scand J Plast Reconstr Surg Hand Surg 1992;26:133-9.
21. Nicosia RF, Lin YJ, Hazelton D, et al. Endogenous regulation of angiogenesis in the rat aorta model: role of vascular endothelial growth factor. Am J Pathol 1997;151:1379-86.
22. Zachary I. Vascular endothelial growth factor. Int J Biochem Cell Biol 1998;30:1169-74.
23. Nissen NN, Polverini PJ, Koch AE, Volin MV, Gamelli RL, DiPietro LA. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 1998;152:1445-52.
24. Corral CJ, Siddiqui A, Wu L, et al. Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg 1999; 134:200-5.
25. Quirinia A, Viidik A. The influence of occlusive dressing and hyperbaric oxygen on flap survival and the healing of ischaemic wounds. Scand J Plast Reconstr Surg Hand Surg 1998;32:1-8.
26. Quirinia A, Viidik A. The effect of hyperbaric oxygen on different phases of healing of ischaemic flap wounds and incisional wounds in skin. Br J Plast Surg 1995;48:583-9.
27. Quirinia A, Viidik A. The influence of dressings on the healing of normal and ischaemic wounds and flap survival. Scand J Plast Reconstr Surg Hand Surg 2001;35:1-6.
28. Zhang F, Fischer K, Komorowska-Timek E, et al. Improvement of skin paddle survival by application of vascular endothelial growth factor in a rat TRAM flap model. Ann Plast Surg 2001;46:314-9.
29. Kryger Z, Zhang F, Dogan T, Cheng C, Lineaweaver WC, Buncke HJ. The effects of VEGF on survival of a random flap in the rat: examination of various routes of administration. Br J Plast Surg 2000;53:234-9.
30. Zhang F, Richards L, Angel MF, et al. Accelerating flap maturation by vascular endothelium growth factor in a rat tube flap model. Br J Plast Surg 2002;55:59-63.
31. Kryger Z, Dogan T, Zhang F, et al. Effects of VEGF administration following ischemia on survival of the gracilis muscle flap in the rat. Ann Plast Surg 1999;43:172-8.
32. Banai S, Jaklitsch MT, Shou M, et al. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 1994;89:2183-9.
33. Takeshita S, Zheng LP, Brogi E, et al. Therapeutic angiogenesis. A single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 1994;93:662-70.
34. Frank C, McDonald D, Bray D, et al. Collagen fibril diameters in the healing adult rabbit medial collateral ligament. Connect Tissue Res 1992;27:251-63.
35. Frank C, McDonald D, Wilson J, Eyre D, Shrive N. Rabbit medial, collateral ligament scar weakness is associated with decreased collagen pyridinoline crosslink density. J Orthop Res 1995;13:157-65.