In vitro inhibition of 7-ethoxyresorufin-O-deethylase (EROD) and p-nitrophenol hydroxylase (PNPH) activities by sesamin in hepatic microsomes from two fish species

Molecular Biology Reports

Volumn 40, Issue 1, 2013, Pages 457-462

  Wagner, Liane ^a   Zlabek, Vladimir ^b   Trattner, Sofia ^a   Zamaratskaia, Galia ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

Author keywords

Atlantic salmon; Common carp; CYP1A; CYP2E1 like protein; Mechanism based inhibition

Indexed keywords

4 NITROPHENOL HYDROXYLASE; CYTOCHROME P450 1A; CYTOCHROME P450 2E1; ETHOXYRESORUFIN DEETHYLASE; OXYGENASE; SESAMIN; UNCLASSIFIED DRUG;

ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; ATLANTIC SALMON; CARP; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; INCUBATION TIME; INHIBITION KINETICS; LIVER MICROSOME; MECHANISM BASED INHIBITION; NONHUMAN;

ANIMALS; ANTIOXIDANTS; CARPS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2E1; DIOXOLES; INHIBITORY CONCENTRATION 50; KINETICS; LIGNANS; MICROSOMES, LIVER; SALMON;

CYPRINUS CARPIO; SALMO SALAR;

EID: 84871286898     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2080-3     Document Type: Article

References (17)

1. Arukwe A (2002) Complementary DNA cloning, sequence analysis and differential organ expression of beta-naphthoflavone-inducible cytochrome P4501A in Atlantic salmon (Salmo salar). Comp Biochem Physiol C 133(4):613-624
2. Hansson MC, Persson ME, Larsson P, Kjellman C, von Schantz T (2006) Polychlorinated biphenyl load, aryl hydrocarbon receptor, and cytochrome P4501a1 induction in a wild population of Atlantic salmon (Salmo salar) from the Baltic Sea. Environ Toxicol Chem 25(8):2197-2207
3. Fisher MA, Mehne C, Means JC, Ide CF (2006) Induction of CYP1A mRNA in carp (Cyprinus carpio) from the Kalamazoo River polychlorinated biphenyl-contaminated superfund site and in a laboratory study. Arch Environ Contam Toxicol 50(1):14-22
4. Thibaut R, Schnell S, Porte C (2006) The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in vitro study. Environ Sci Technol 40(16):5154-5160
5. Zamaratskaia G, Zlabek V (2011) Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors. Fish Physiol Biochem 37(4):969-976
6. Sapone A, Gustavino B, Monfrinotti M, Canistro D, Broccoli M, Pozzetti L, Affatato A, Valgimigli L, Forti GC, Pedulli GF et al (2007) Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water. Mutat Res Genet Toxicol Environ Mutagen 626(1-2):143-154
7. van der Oost R, Beyer J, Vermeulen NPE (2003) Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ Toxicol Pharmacol 13(2):57-149
8. Trattner S, Kamal-Eldin A, Brannas E, Moazzami A, Zlabek V, Larsson P, Ruyter B, Gjoen T, Pickova J (2008) Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. Lipids 43(11):989-997
9. Mraz J, Schlechtriem C, Olohan LA, Fang YX, Cossins AR, Zlabek V, Samuelsen T, Pickova J (2010) Sesamin as a potential modulator of fatty acid composition in common carp (Cyprinus carpio). Aquac Res 41(11):e851-e861
10. Rasmussen MK, Ekstrand B, Zamaratskaia G (2011) Comparison of cytochrome P450 concentrations and metabolic activities in porcine hepatic microsomes prepared with two different methods. Toxicol In Vitro 25(1):343-346
11. Zamaratskaia G, Zlabek V (2009) EROD and MROD as markers of cytochrome P450 1A activities in hepatic microsomes from entire and castrated male pigs. Sensors 9(3):2134-2147
12. Wilkinson CF, Murray M, Marcus CB (1984) Interactions of methylenedioxyphenyl compounds with cytochrome P450 and effects on microsomal oxidation. In: Hodgson JR, Bend JR, Philpot RM (eds) Reviews in biochemical toxicology, vol 6. Elsevier, Amsterdam, pp 27-63
13. Siu ECK, Tyndale RF (2008) Selegiline (L-deprenyl) is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice. J Pharmacol Exp Ther 324:992-999
14. Yasuda K, Ikushiro S, Kamakura M, Ohta M, Sakaki T (2010) Metabolism of sesamin by cytochrome P450 in human liver microsomes. Drug Metab Dispos 38:2117-2123
15. Yasuda K, Ikushiro S, Kamakura M, Munetsuna E, Ohta M, Sakaki T (2011) Sequential metabolism of sesamine by cytochrome P450 and UDP- glucuronosyltrasferase in human liver. Drug Metab Dispos 39:1538-1545
16. Trattner S, Ruyter B, Ostbye TK, Kamal-Eldin A, Moazzami A, Pan J, Gjoen T, Brannas E, Zlabek V, Pickova J (2011) Influence of dietary sesamin, a bioactive compound on fatty acids and expression of some lipid regulating genes in Baltic Atlantic salmon (Salmo salar L.) juveniles. Physiol Res 60(1):125-137
17. Murray M (2000) Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation. Curr Drug Metab 1(1):67-84