Long QT syndrome, a purely electrical disease? Not anymore

European Heart Journal

Volumn 30, Issue 3, 2009, Pages 253-255

  De Ferrari, Gaetano M ^a   Schwartz, Peter J ^a,b,c,d,e  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^d Hatter Institute for Cardiovascular Research   (South Africa)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; VERAPAMIL;

BRUGADA SYNDROME; CALCIUM CELL LEVEL; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CHANNELOPATHY; CLINICAL FEATURE; COMPARATIVE STUDY; DIAGNOSTIC ACCURACY; ECHOCARDIOGRAPHY; EDITORIAL; ELECTROCARDIOGRAPHY; GENE MUTATION; GENETIC ASSOCIATION; HEART ARREST; HEART ARRHYTHMIA; HEART CONTRACTION; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE CONTRACTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HEART MUSCLE TENSION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE WALL; HEART VENTRICLE WALL MOTION; HUMAN; LONG QT SYNDROME; M MODE ECHOCARDIOGRAPHY; MUSCLE ACTION POTENTIAL; PRIORITY JOURNAL; QT DISPERSION; QT INTERVAL; QT PROLONGATION; R WAVE; RISK ASSESSMENT; SHORT QT SYNDROME; SYNCOPE; SYSTOLE; TISSUE DOPPLER IMAGING;

HUMANS; LONG QT SYNDROME; MYOCARDIAL CONTRACTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 59749094476     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn587     Document Type: Editorial

References (15)

1. Schwartz PJ, Crotti L. Long QT and short QT syndromes. In: Zipes DP, Jalife J eds. Cardiac Electrophysiology. From Cell to Bedside, 5th edn. Philadelphia, PA: Elsevier; 2009 (in press).
2. Eckardt L, Brugada P, Morgan J, Breithardt G. Ventricular tachycardia. In: Camm AJ, Lüscher TF, Serruys PW eds. The ESC Textbook of Cardiovascular Medicine. Oxford: Blackwell Publishing Ltd; 2006. p949-972.
3. Sarkozy A, Brugada P. Sudden cardiac death and inherited arrhythmias syndrome. J Cardiovasc Electrophysiol 2005;16(Suppl. 1):S8-S20.
4. Nador F, Beria G, De Ferrari GM, Stramba-Badiale M, Locati EH, Lotto A, Schwartz PJ. Unsuspected echocardiographic abnormality in the long Q-T syndrome: diagnostic, prognostic, and pathogenetic implications. Circulation 1991;84:1530-1542.
5. De Ferrari GM, Nador F, Beria G, Sala S, Lotto A, Schwartz PJ. Effect of calcium channel block on the wall motion abnormality of the idiopathic long QT syndrome. Circulation 1994;89:2126-2132.
6. Haugaa KH, Edvardsen T, Leren TP, Gran JM, Smiseth OA, Amlie JP. Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high risk individuals with long QT syndrome. Eur Heart J 2009;30:330-337. doi:10.1093/eurheartj/ehn466.
7. Jervell A, Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death. Am Heart J 1957;54:59-68.
8. Schwartz PJ, Spazzolini C, Crotti L, Bathen J, Amlie JP, Timothy K, Shkolnikova M, Berul CI, Bitner-Glindzicz M, Toivonen L, Horie M, Schulze-Bahr E, Denjoy I. The Jervell and Lange-Nielsen syndrome. Natural history, molecular basis, and clinical outcome. Circulation 2006;113:783-790.
9. Nakayama K, Yamanari H, Otsuka F, Fukushima K, Saito H, Fujimoto Y, Emori T, Matsubara H, Uchida S, Ohe T. Dispersion of regional wall motion abnormality in patients with long QT syndrome. Heart 1998;80:245-250.
10. Savoye C, Klug D, Denjoy I, Ennezat PV, Le Tourneau T, Guicheney P, Kacet S. Tissue Doppler echocardiography in patients with long QT syndrome. Eur J Echocardiogr 2003;4:209-213.
11. Edvardsen T, Urheim S, Skulstad H, Steine K, Ihlen H, Smiseth OA. Quantification of left ventricular systolic function by tissue Doppler echocardiography: added value of measuring pre- and postejection velocities in ischemic myocardium. Circulation 2002;105:2071-2077.
12. Priori SG, Schwartz PJ, Napolitano C, Bloise R, Ronchetti E, Grillo M, Vicentini A, Spazzolini C, Nastoli J, Bottelli G, Folli R, Cappelletti D. Risk stratification in the long-QT syndrome. N Engl J Med 2003;348: 1866-1874.
13. Crotti L, Spazzolini C, Schwartz PJ, Shimizu W, Denjoy I, Schulze-Bahr E, Zaklyazminskaya EV, Swan H, Ackerman MJ, Moss AJ, Wilde AA, Horie M, Brink PA, Insolia R, De Ferrari GM, Crimi G: The common long QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification. Circulation 2007;116:2366-2375.
14. Morad M, Trautwein W. The effect of the duration of the action potential duration on contraction in the mammalian heart. Plugers Arch Gesamte Physiol Menschen Tiere 1968;229:66-82.
15. De Ferrari GM, Viola MC, D'Amato E, Antolini R, Forti S. Distinct patterns of calcium transients during early and delayed afterdepolarizations induced by isoproterenol in ventricular myocytes. Circulation 1995;91:2510-2515.