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Volumn 40, Issue 1, 2013, Pages 51-58

Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis

Author keywords

Acylated ghrelin; Apoptosis; Epilepsy; Hippocampus; Neuroprotective effect; Pilocarpine

Indexed keywords

CASPASE 3; GHRELIN; GHRELIN RECEPTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PILOCARPINE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

EID: 84871274773     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1993-1     Document Type: Article
Times cited : (31)

References (35)
  • 1
    • 0030559690 scopus 로고    scopus 로고
    • Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures
    • 8985694 10.1016/S0920-1211(96)00048-4 1:STN:280:DyaK2s7jvVKksg%3D%3D
    • Mello LE, Covolan L (1996) Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. Epilepsy Res 26:123-129
    • (1996) Epilepsy Res , vol.26 , pp. 123-129
    • Mello, L.E.1    Covolan, L.2
  • 2
    • 0020545095 scopus 로고
    • Limbic seizures produced by pilocarpine in rats: Behavioral, electroencephalographic and neuropathological study
    • 6639740 10.1016/0166-4328(83)90136-5 1:CAS:528:DyaL3sXlvFaktbo%3D
    • Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L (1983) Limbic seizures produced by pilocarpine in rats: behavioral, electroencephalographic and neuropathological study. Behav Brain Res 9:315-335
    • (1983) Behav Brain Res , vol.9 , pp. 315-335
    • Turski, W.A.1    Cavalheiro, E.A.2    Schwarz, M.3    Czuczwar, S.J.4    Kleinrok, Z.5    Turski, L.6
  • 3
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • 9133393 1:CAS:528:DyaK2sXjt1Wqtbw%3D
    • Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH (1997) Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 17:3727-3738
    • (1997) J Neurosci , vol.17 , pp. 3727-3738
    • Parent, J.M.1    Yu, T.W.2    Leibowitz, R.T.3    Geschwind, D.H.4    Sloviter, R.S.5    Lowenstein, D.H.6
  • 4
    • 0037423289 scopus 로고    scopus 로고
    • Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
    • 12458207 10.1074/jbc.M211598200 1:CAS:528:DC%2BD3sXot1Olsg%3D%3D
    • Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (2003) Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 278(6):3897-3902
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 3897-3902
    • Barthwal, M.K.1    Sathyanarayana, P.2    Kundu, C.N.3    Rana, B.4    Pradeep, A.5    Sharma, C.6    Woodgett, J.R.7    Rana, A.8
  • 5
    • 34250205262 scopus 로고    scopus 로고
    • Ghrelin protects cortical neuronagainst focal ischemia/reperfusion in rats
    • 10.1016/j.bbrc.2007.05.192
    • Miao Y, Xia Q, Hou Z, Zheng Y, Pan H, Zhu S (2007) Ghrelin protects cortical neuronagainst focal ischemia/reperfusion in rats. Biochem Biophys Res Commun 359:780-795
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 780-795
    • Miao, Y.1    Xia, Q.2    Hou, Z.3    Zheng, Y.4    Pan, H.5    Zhu, S.6
  • 6
    • 48249155328 scopus 로고    scopus 로고
    • IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus
    • 18338791 10.1002/glia.20653
    • Choi YS, Cho HY, Hoyt KR, Naegele JR, Obrietan K (2008) IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus. Glia 56:791-800
    • (2008) Glia , vol.56 , pp. 791-800
    • Choi, Y.S.1    Cho, H.Y.2    Hoyt, K.R.3    Naegele, J.R.4    Obrietan, K.5
  • 7
    • 0035783732 scopus 로고    scopus 로고
    • Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus
    • 11595032 10.1046/j.0953-816x.2001.01713.x 1:STN:280: DC%2BD3MrkvVyntA%3D%3D
    • Ekdahl CT, Mohapel P, Elmér E, Lindvall O (2001) Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus. Eur J Neurosci 14:937-945
    • (2001) Eur J Neurosci , vol.14 , pp. 937-945
    • Ekdahl, C.T.1    Mohapel, P.2    Elmér, E.3    Lindvall, O.4
  • 8
    • 33748205569 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes
    • 16899724 10.1523/JNEUROSCI.1986-05.2006 1:CAS:528:DC%2BD28Xos1Kjur0%3D
    • Cole-Edwards KK, Musto AE, Bazan NG (2006) C-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes. J Neurosci 26:8295-8304
    • (2006) J Neurosci , vol.26 , pp. 8295-8304
    • Cole-Edwards, K.K.1    Musto, A.E.2    Bazan, N.G.3
  • 9
    • 3142763069 scopus 로고    scopus 로고
    • Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: The role of the MAPK family
    • Huang NK, Lin YL, Cheng JJ, Lai WL (2004) Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life Sci 75:649-657
    • (2004) Life Sci , vol.75 , pp. 649-657
    • Huang, N.K.1    Lin, Y.L.2    Cheng, J.J.3    Lai, W.L.4
  • 10
    • 13844262643 scopus 로고    scopus 로고
    • The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain I/R-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways
    • 15713276 10.1016/j.brainres.2004.11.050 1:CAS:528:DC%2BD2MXhtlSmu78%3D
    • Guan QH, Pei DS, Zhang QG, Hao ZB, Xu TL, Zhang GY (2005) The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain I/R-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways. Brain Res 1035:51-59
    • (2005) Brain Res , vol.1035 , pp. 51-59
    • Guan, Q.H.1    Pei, D.S.2    Zhang, Q.G.3    Hao, Z.B.4    Xu, T.L.5    Zhang, G.Y.6
  • 11
    • 0027938445 scopus 로고
    • C-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
    • 7935387 1:CAS:528:DyaK2cXmslGjtrs%3D
    • Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R et al (1994) c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 14:6683-6688
    • (1994) Mol Cell Biol , vol.14 , pp. 6683-6688
    • Minden, A.1    Lin, A.2    Smeal, T.3    Dérijard, B.4    Cobb, M.5    Davis, R.6
  • 12
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • 10604470 10.1038/45230 1:CAS:528:DC%2BD3cXjs1Ki
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 13
    • 33646190291 scopus 로고    scopus 로고
    • Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat
    • 16600402 10.1016/j.regpep.2006.02.005 1:CAS:528:DC%2BD28XksVClsr0%3D
    • Hou ZC, Miao Y, Gao L, Pan H, Zhu S (2006) Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat. Regul Pept 134:126-131
    • (2006) Regul Pept , vol.134 , pp. 126-131
    • Hou, Z.C.1    Miao, Y.2    Gao, L.3    Pan, H.4    Zhu, S.5
  • 14
    • 34547110359 scopus 로고    scopus 로고
    • Ghrelin and its unacylated isoform stimulated the growth of adrenocortical tumor cells via an anti-apoptotic pathway
    • 10.1152/ajpendo.00377.2006
    • Delhanty PJ, van Koetsveld PM, Gauna C, van de Zande B, Vitale G, Hofland LJ et al (2007) Ghrelin and its unacylated isoform stimulated the growth of adrenocortical tumor cells via an anti-apoptotic pathway. Am J Endocrinol Metab 293:302-309
    • (2007) Am J Endocrinol Metab , vol.293 , pp. 302-309
    • Delhanty, P.J.1    Van Koetsveld, P.M.2    Gauna, C.3    Van De Zande, B.4    Vitale, G.5    Hofland, L.J.6
  • 15
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI3-kinase/AKT
    • 12486113 10.1083/jcb.200207165 1:CAS:528:DC%2BD3sXjt1ej
    • Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI3-kinase/AKT. J Cell Biol 159:1029-1037
    • (2002) J Cell Biol , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3    Catapano, F.4    Bonissoni, S.5    Fubini, A.6
  • 16
    • 54049141243 scopus 로고    scopus 로고
    • Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation
    • 18675863 10.1016/j.peptides.2008.07.002 1:CAS:528:DC%2BD1cXht12ltL7L
    • Rossi F, Castelli A, Bianco MJ, Bertone C, Brama M, Santiemma V (2008) Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation. Peptides 29:2046-2051
    • (2008) Peptides , vol.29 , pp. 2046-2051
    • Rossi, F.1    Castelli, A.2    Bianco, M.J.3    Bertone, C.4    Brama, M.5    Santiemma, V.6
  • 17
    • 33845910446 scopus 로고    scopus 로고
    • Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation
    • 17053024 10.1210/en.2006-0991 1:CAS:528:DC%2BD2sXjsV2qsQ%3D%3D
    • Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park S (2007) Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148:148-159
    • (2007) Endocrinology , vol.148 , pp. 148-159
    • Chung, H.1    Kim, E.2    Lee, D.H.3    Seo, S.4    Ju, S.5    Lee, D.6    Kim, H.7    Park, S.8
  • 18
    • 39649099593 scopus 로고    scopus 로고
    • Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model
    • 18215442 10.1016/j.peptides.2007.11.020 1:CAS:528:DC%2BD1cXislKks7c%3D
    • Obay BD, Tasdemir E, Tümer C, Bilgin HM, Atmaca M (2008) Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29:448-455
    • (2008) Peptides , vol.29 , pp. 448-455
    • Obay, B.D.1    Tasdemir, E.2    Tümer, C.3    Bilgin, H.M.4    Atmaca, M.5
  • 19
    • 33947513078 scopus 로고    scopus 로고
    • Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion
    • 17294832 1:CAS:528:DC%2BD28Xht1Cmsr7P
    • Liu Y, Wang PS, Xie D, Liu K, Chen L (2006) Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol 49:244-250
    • (2006) Chin J Physiol , vol.49 , pp. 244-250
    • Liu, Y.1    Wang, P.S.2    Xie, D.3    Liu, K.4    Chen, L.5
  • 20
    • 61349154154 scopus 로고    scopus 로고
    • Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats
    • 19429016 10.1016/j.neulet.2009.01.067 1:CAS:528:DC%2BD1MXivVeiurc%3D
    • Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z (2009) Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453:58-61
    • (2009) Neurosci Lett , vol.453 , pp. 58-61
    • Xu, J.1    Wang, S.2    Lin, Y.3    Cao, L.4    Wang, R.5    Chi, Z.6
  • 21
    • 0036813472 scopus 로고    scopus 로고
    • Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death
    • 12351720 1:CAS:528:DC%2BD38Xns1Cju7s%3D
    • Henshall DC, Araki T, Schindler CK, Lan JQ, Tiekoter KL, Taki W, Simon RP et al (2002) Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci 22:8458-8465
    • (2002) J Neurosci , vol.22 , pp. 8458-8465
    • Henshall, D.C.1    Araki, T.2    Schindler, C.K.3    Lan, J.Q.4    Tiekoter, K.L.5    Taki, W.6    Simon, R.P.7
  • 22
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • 10579998 10.1101/gad.13.22.2905 1:CAS:528:DyaK1MXnvVCltLo%3D
    • Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 23
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • 11686294 1:CAS:528:DC%2BD3MXmvFCqs7c%3D
    • Lawlor MA, Alessi DR (2001) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114:2903-2910
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 24
    • 0037104660 scopus 로고    scopus 로고
    • Akt1 regulates a JNK scaffold during excitotoxic apoptosis
    • 12194869 10.1016/S0896-6273(02)00821-8 1:CAS:528:DC%2BD38XmslSlsbo%3D
    • Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B et al (2002) Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35:697-709
    • (2002) Neuron , vol.35 , pp. 697-709
    • Kim, A.H.1    Yano, H.2    Cho, H.3    Meyer, D.4    Monks, B.5    Margolis, B.6
  • 25
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: Involvement of 30, 50-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • 17068144 10.1210/en.2006-0266 1:CAS:528:DC%2BD2sXhtlOjtrw%3D
    • Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F et al (2007) Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 30, 50-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology 148:512-529
    • (2007) Endocrinology , vol.148 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5    Bertuzzi, F.6
  • 26
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Gibson TB, Xu BE, Karandikar M, Berman K et al (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183
    • (2001) Endocr Rev , vol.22 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Gibson, T.B.3    Xu, B.E.4    Karandikar, M.5    Berman, K.6
  • 27
    • 81755182299 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin binging to membranes and to ghrelin receptor: Towards a better understanding of the underlying mechanisma
    • Staes E, Absil PA, Lins L, Brasseur R, Deleu M, Lecouturier N et al (2010) Acylated and unacylated ghrelin binging to membranes and to ghrelin receptor: towards a better understanding of the underlying mechanisma. Biochim Biophys Acta 1798: 2102-2113
    • (2010) Biochim Biophys Acta , vol.1798 , pp. 2102-2113
    • Staes, E.1    Absil, P.A.2    Lins, L.3    Brasseur, R.4    Deleu, M.5    Lecouturier, N.6
  • 28
    • 0031972678 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal with-drawal in cerebellar granule neurons
    • 9425017 1:CAS:528:DyaK1cXlsFaitQ%3D%3D
    • Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, Ham J (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal with-drawal in cerebellar granule neurons. J Neurosci 18:751-762
    • (1998) J Neurosci , vol.18 , pp. 751-762
    • Watson, A.1    Eilers, A.2    Lallemand, D.3    Kyriakis, J.4    Rubin, L.L.5    Ham, J.6
  • 29
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin structure and function
    • Kojima M, Kangawa K (2005) Ghrelin structure and function. Physiol Rev 85:495-522
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 30
    • 0029001403 scopus 로고
    • Up-regulation of Bax and downregulation of Bcl-2 is associated with kainate-induced apoptosis in mouse brain
    • 7675327 10.1016/0304-3940(95)11619-8 1:CAS:528:DyaK2MXms1yqsrg%3D
    • Gillardon F, Wickert H, Zimmermann M (1995) Up-regulation of Bax and downregulation of Bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett 192:85-88
    • (1995) Neurosci Lett , vol.192 , pp. 85-88
    • Gillardon, F.1    Wickert, H.2    Zimmermann, M.3
  • 31
    • 4143066849 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation and apoptosis activated by damaged microtubules requiremTOR and are regulated by Akt
    • 15208671 10.1038/sj.onc.1207698 1:CAS:528:DC%2BD2cXmtVCns7s%3D
    • Asnaghi L, Calastretti A, Bevilacqua A, D'Agnano I, Gatti G, Canti G et al (2004) Bcl-2 phosphorylation and apoptosis activated by damaged microtubules requiremTOR and are regulated by Akt. Oncogene 23:5781-5791
    • (2004) Oncogene , vol.23 , pp. 5781-5791
    • Asnaghi, L.1    Calastretti, A.2    Bevilacqua, A.3    D'Agnano, I.4    Gatti, G.5    Canti, G.6
  • 32
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • 9027315 10.1126/science.275.5303.1132 1:CAS:528:DyaK2sXhtlKjtro%3D
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 33
    • 34249694588 scopus 로고    scopus 로고
    • Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats
    • 17512090 10.1016/j.peptides.2007.04.003 1:CAS:528:DC%2BD2sXmtVaiu78%3D
    • Obay BD, Tasdemir E, Tümer C, Bilgin HM, Sermet A (2007) Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 28:1214-1219
    • (2007) Peptides , vol.28 , pp. 1214-1219
    • Obay, B.D.1    Tasdemir, E.2    Tümer, C.3    Bilgin, H.M.4    Sermet, A.5
  • 34
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • 12130749 10.1124/jpet.102.034827 1:CAS:528:DC%2BD38Xls1Ogtbg%3D
    • Banks WA, Tschöp M, Robinson SM, Heiman ML (2002) Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822-827
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschöp, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 35
    • 0033083082 scopus 로고    scopus 로고
    • Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
    • 10092043 10.1016/S0166-2236(98)01362-9 1:CAS:528:DyaK1MXhtVCrtLg%3D
    • West MJ (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22:51-61
    • (1999) Trends Neurosci , vol.22 , pp. 51-61
    • West, M.J.1


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