Pharmacokinetic study of unbound forsythiaside in rat blood and bile by microdialysis coupled with HPLC method

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 37, Issue 3, 2012, Pages 173-177

  Chu, Yang ^a   Wang, Xiangyang ^a   Guo, Jiahua ^a   Li, Wei ^a   Ma, Xiaohui ^a   Zhu, Yonghong ^a  

^a Tianjin Tasly Institute   (China)

Author keywords

Forsythiaside; Hepatobiliary excretion; HPLC; Microdialysis; Pharmacokinetics

Indexed keywords

ACETONITRILE; FORMIC ACID; FORSYTHIASIDE; PLANT GLYCOSIDE; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIMIT OF QUANTITATION; MALE; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; REPRODUCIBILITY;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; GLYCOSIDES; MALE; MICRODIALYSIS; RATS; RATS, WISTAR;

EID: 84871273043     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-012-0084-y     Document Type: Article

References (17)

1. Es-Safi NE, Khlifi S, Kerhoas L, Kollmann A, El Abbouyi A, Ducrot PH (2005) Antioxidant constituents of the aerial parts of Globularia alypum growing in Morocco. J Nat Prod 68:1293-1296
2. Iizuka T, Nagai M (2005) Vasorelaxant effects of forsythiaside from the fruits of Forsythia suspensa. Yakugaku Zasshi 125:219-224
3. Kim JM, Kim S, Kim DH, Lee CH, Park SJ, Jung JW, Ko KH, Cheong JH, Lee SH, Ryu JH (2011) Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil. Eur J Pharmacol 660:326-333
4. Ko HC, Wei BL, Chiou WF (2005) Dual regulatory effect of plant extracts of Forsythia suspense on RANTES and MCP-1 secretion in influenza A virus-infected human bronchial epithelial cells. J Ethnopharmacol 102:418-423
5. Li YX, Jiang XH, Liang HY, Li X (2008) Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Biomed Chromatogr 22:361-366
6. Li YX, Peng C, Zhang RQ, Li X, Jiang XH (2009) Pharmacokinetics of phillyrin and forsythiaside following iv administration to beagle dog. Eur J Drug Metab Pharmacokinet 34:79-83
7. Li HW, Wu JF, Zhang ZW, Ma YY, Liao FF, Zhang Y, Wu GJ (2011) Forsythoside A inhibits the avian infectious bronchitis virus in cell culture. Phytother Res 25:338-342
8. Lu T, Piao XL, Zhang Q, Wang D, Piao XS, Kim SW (2010) Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Food Chem Toxicol 48:764-770
9. Nazemiyeh H, Rahman MM, Gibbons S, Nahar L, Delazar A, Ghahramani MA, Talebpour AH, Sarker SD (2008) Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug- resistant strains of Staphylococcus aureus. J Nat Med 62:91-95
10. Ozaki Y, Rui J, Tang YT (2000) Antiinflammatory effect of Forsythia suspensa V(AHL) and its active principle. Biol Pharm Bull 23:365-367
11. Piao XL, Cho EJ, Jang MH, Cui J (2009) Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage. Phytother Res 23:938-942
12. Prieto JM, Recio MC, Giner RM, Manez S, Giner EM, Rios JL (2003) Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 55:1275-1282
13. Qu H, Zhang Y, Wang Y, Li B, Sun W (2008) Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa. J Pharm Pharmacol 60:261-266
14. Shi R, Xuan Z, Ma Y, Liu Y, Lu H, Sun T (2009) Pharmacokinetics of forsythoside after intravenous administration in beagle dogs. Eur J Drug Metab Pharmacokinet 34:101-105
15. Wang GN, Pan RL, Liao YH, Chen Y, Tang JT, Chang Q (2010) An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study. J Chromatogr B 878:102-106
16. Ye JX, Wei W, Quan LH, Liu CY, Chang Q, Liao YH (2010) An LC- MS/MS method for the simultaneous determination of chlorogenic acid, forsythiaside A and baicalin in rat plasma and its application to pharmacokinetic study of shuang-huang-lian in rats. J Pharm Biomed Anal 52:625-630
17. Zhou BN, Bahler BD, Hofmann GA, Mattern MR, Johnson RK, Kingston DG (1998) Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCa-inhibitory activity. J Nat Prod 61:1410-1412