An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 1, 2009, Pages 102-106

  Wang, Geng Nan ^a   Pan, Rui Le ^a   Liao, Yong Hong ^a   Chen, Ying ^a   Tang, Jing Tian ^b   Chang, Qi ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Bioavailability; Forsythiaside; LC MS MS; Pharmacokinetics

Indexed keywords

ANALYTES; BIOAVAILABILITY; CONCENTRATION RANGES; EPICATECHIN; EXTRACTION RECOVERY; HIGHLY SENSITIVE; INTERNAL STANDARDS; LC-MS/MS; LIMITS OF DETECTION; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; RAT PLASMA; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRIC;

ACETONITRILE; BIOCHEMISTRY; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ORGANIC ACIDS; PHARMACOKINETICS; PLASMA (HUMAN);

EXTRACTION;

ACETONITRILE; ANTIPYRETIC AGENT; EPICATECHIN; FORMIC ACID; FORSYTHIASIDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISCRIMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; AREA UNDER CURVE; CATECHIN; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; GLYCOSIDES; LEAST-SQUARES ANALYSIS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 71449115902     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.11.029     Document Type: Article

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