An LC-MS/MS method for the simultaneous determination of chlorogenic acid, forsythiaside A and baicalin in rat plasma and its application to pharmacokinetic study of Shuang-huang-lian in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 625-630

  Ye, Jun Xiao ^a   Wei, Wang ^a   Quan, Li Hui ^a   Liu, Chun Yu ^a   Chang, Qi ^a   Liao, Yong Hong ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

LC MS MS; Pulmonary delivery; Shuang huang lian; Traditional Chinese medicine

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; BAICALIN; CHINESE DRUG; CHLOROGENIC ACID; FORMIC ACID; FORSYTHIA EXTRACT; FORSYTHIASIDE A; METHANOL; SCUTELLAREIN; SHUANG HUANG LIAN; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER; FLAVONOID; FORSYTHIASIDE; GLYCOSIDE; HERBACEOUS AGENT; SHUANG-HUANG-LIAN;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; ANIMAL; BLOOD; COMPARATIVE STUDY; LIQUID CHROMATOGRAPHY; PROCEDURES; WISTAR RAT;

ANIMALS; CHLOROGENIC ACID; CHROMATOGRAPHY, LIQUID; DRUGS, CHINESE HERBAL; FLAVONOIDS; GLYCOSIDES; MALE; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 77950368054     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.01.035     Document Type: Article

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